rewire.it
Paper-reported evidence

Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

2025 · Peer-reviewed · PRX Life 2025 journal article

Paper-reported results. The values below come from this source, not an independent rewire.it run.

Open primary paper →DOI: 10.1103/zhx7-hcmm

Final journal Table I, ESM2: OFS PP Aggregate Mean 0.403 checked directly; manuscript PMC11257618 printed the same value. Other models in the table are imported ProteinGym baselines; this row is the authors’ own evaluation.

1 verified numerical rows · source checked 2026-09-15

Paper-reportedAuthor's model

ESM2 OFS pseudo-perplexity

protein variant fitness prediction

Reported score
0.403
Metric
Spearman rho
Dataset / split
ProteinGym substitutions · aggregate across assays

authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays

Table I, ESM2: OFS PP row, Aggregate Mean Spearman correlation columnVerify at source →