rewire.it
Paper-reported evidence

PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space

2026 · Peer-reviewed · version of record

Paper-reported results. The values below come from this source, not an independent rewire.it run.

Open primary paper →DOI: 10.1186/s12864-026-12976-5

Primary full text via Europe PMC XML; venue: BMC Genomics; PMC ID: PMC13425921.

2 verified numerical rows · source checked 2026-09-15

Paper-reportedIndependent paper evaluation

ESM-2 (8M)

Mutated RBD binding prediction

Reported score
0.0248± 0.01
Metric
R²
Dataset / split
PRIME mutated RBD · position-stratified

Frozen mean-pooled representation with downstream regression; position-stratified split.

Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² columnVerify at source →
Paper-reportedIndependent paper evaluation

ESM-C (300M)

Mutated RBD binding prediction

Reported score
-0.0162± 0.01
Metric
R²
Dataset / split
PRIME mutated RBD · position-stratified

Frozen mean-pooled representation with downstream regression; position-stratified split.

Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² columnVerify at source →