rewire.it
Paper-reported evidence

ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction

2023 · Preprint · PMC10723403.1

Paper-reported results. The values below come from this source, not an independent rewire.it run.

Open primary paper →DOI: 10.1101/2023.12.07.570727

Primary full text via Europe PMC XML; venue: bioRxiv; PMC ID: PMC10723403.

2 verified numerical rows · source checked 2026-09-15

Paper-reportedIndependent paper evaluation

ESM-2 (15B)

Zero-shot substitution mutation effects: stability

Reported score
0.488
Metric
Mean Spearman rho
Dataset / split
ProteinGym substitution DMS: stability assays

Zero-shot mutation scores; average Spearman across stability-category assays.

Table A7, ESM-2 (15B) row, Stability columnVerify at source →
Paper-reportedIndependent paper evaluation

ProteinMPNN

Zero-shot substitution mutation effects: stability

Reported score
0.566
Metric
Mean Spearman rho
Dataset / split
ProteinGym substitution DMS: stability assays

Zero-shot mutation scores; average Spearman across stability-category assays.

Table A7, ProteinMPNN row, Stability columnVerify at source →