rewire.it
Paper-reported evidence

Structure-Informed Protein Language Models are Robust Predictors for Variant Effects

2025 · Peer-reviewed · Human Genetics 2025 journal article (online 2024)

Paper-reported results. The values below come from this source, not an independent rewire.it run.

Open primary paper →DOI: 10.1007/s00439-024-02695-w

Final Human Genetics Table 4, AA+SS+RSA+CM AUROC .803 checked directly; Research Square preprint Table 3 prints the same value.

1 verified numerical rows · source checked 2026-09-15

Paper-reportedAuthor's model

structure-informed pLM

protein variant-effect classification

Reported score
0.803
Metric
AUROC
Dataset / split
variant-effects benchmark · paper evaluation

combined amino-acid, secondary structure, solvent accessibility and contact-map scoring

Table 4, AA+SS+RSA+CM row, AUROC columnVerify at source →