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Omics and molecular biology

Biological model benchmark database

Find models, understand how they are tested, and inspect the evidence behind their results.

Methods and evaluation records

Biological models and model families. Evaluated versions, configurations and pipelines are linked separately.

59 matching records · Release 2026-09-17-d277315f7d76

Model · discovered

AlphaGenome

AlphaGenome predicts regulatory activity and variant effects from long DNA sequences, with outputs for expression, splicing, chromatin and contact maps.

dna-genomes · 4 linked sources

Model · discovered

Boltz-2

Boltz predicts biomolecular complex structures; Boltz-2 also predicts binding affinity.

molecular-interactions · 7 linked sources

Model · discovered

Chai-1

Chai-1 predicts the structures of biomolecular complexes containing proteins, nucleic acids and small molecules.

proteins-complexes · molecular-interactions · 3 linked sources

Model · discovered

DiffDock-L

DiffDock-L places small-molecule ligands in protein structures using a diffusion docking model.

molecular-interactions · 3 linked sources

Model · discovered

DNABERT-2

DNABERT-2 learns DNA representations that can be adapted to genomic prediction tasks.

dna-genomes · 6 linked sources

Model · discovered

ESM-2

ESM-2 is a family of protein sequence encoders that produce representations for downstream protein analyses.

proteins-complexes · 4 linked sources

Model · discovered

ESMFold

ESMFold predicts protein structures directly from amino-acid sequence using ESM-2 representations.

proteins-complexes · 4 linked sources

Model · discovered

Evo 2

Evo 2 models and generates DNA over long contexts at single-nucleotide resolution.

dna-genomes · microbes-communities · 5 linked sources

Model · discovered

GEARS

GEARS predicts transcriptional responses to single- and multi-gene perturbations from single-cell perturbation screens.

cells-tissues · 4 linked sources

Model · discovered

Geneformer

Geneformer represents single-cell transcriptomes as ranked genes and learns contextual gene and cell representations.

cells-tissues · 3 linked sources

Model · discovered

METAGENE-1

METAGENE-1 is an autoregressive DNA/RNA sequence model trained on wastewater metagenomic data.

microbes-communities · 5 linked sources

Model · discovered

MIMIC

MIMIC represents DNA, RNA, protein and associated molecular measurements in a shared multimodal model.

rna-transcriptomes · proteins-complexes · 5 linked sources

Model · discovered

mRNA-FM

mRNA-FM encodes coding RNA with codon-level tokens to produce representations for downstream analysis.

rna-transcriptomes · 3 linked sources

Model · discovered

Nucleotide Transformer v2

Nucleotide Transformer v2 represents DNA using an encoder pretrained on multiple species.

dna-genomes · 8 linked sources

Model · discovered

Pangolin

Pangolin predicts splice-site strength and changes caused by genetic variants.

dna-genomes · 3 linked sources

Model · discovered

ProkBERT

ProkBERT is a family of microbial DNA encoders used for sequence representation, promoter prediction and phage identification.

microbes-communities · 5 linked sources

Model · discovered

ProteinMPNN

ProteinMPNN designs amino-acid sequences for a supplied protein backbone.

proteins-complexes · 6 linked sources

Model · discovered

RhoFold+

RhoFold+ predicts RNA three-dimensional structures from RNA sequence with alignment information.

rna-transcriptomes · 4 linked sources

Model · discovered

RNA-FM

RNA-FM learns contextual representations of RNA nucleotides for downstream RNA analyses.

rna-transcriptomes · 4 linked sources

Model · discovered

scFoundation

scFoundation produces contextual cell and gene representations from gene-expression measurements.

cells-tissues · 4 linked sources

About the evidence

Published evaluations and rewire evaluations are records in the same database, with their origin shown beside each result. This release includes 1422 source-checked literature result rows and 12 metric rows from existing rewire runs.

Source checked does not mean independently reproduced. Comparisons require compatible data, protocols and metrics. Missing details stay visible.

Rewire evaluations

Read the protocol, coverage and limitations behind our corrected splice-variant evaluation.

MFASS v2 evaluation →

Correction history

MFASS v1 is superseded. Its original tables and methods remain available as an archived report.

Archived MFASS v1 report →
Collection coverage and remaining gaps

This is a dated collection, not an exhaustive model census. Models, methods, evaluated configurations and pipelines are listed separately. Counts describe records, not unique checkpoints or independent experiments.

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  "source_checked_results": 1422,
  "rewire_result_rows": 12,
  "scope": "Specialist omics and molecular models; no clinical assistants or standalone medical imaging.",
  "limitation": "A dated discovery and source-transcription review, not an exhaustive census or independent reproduction of external experiments."
}

Download the database

Release 2026-09-17-d277315f7d76 · 2026-09-17

Original literature downloads

The original 100-paper collection is retained for citation history. These files include six result rows excluded from the current omics scope; use the database release above for the reviewed collection.