Pangolin predicts changes in splice-site strength from DNA variants. It accepts variant files or custom sequence inputs.
Shared profile: Pangolin. This page retains the exact record and its evaluation context.
Explanatory profile: source reviewed · Automated source review, 2026-09-16. This does not change the review status of its results.
| Property | Description and evidence |
|---|---|
| Masking | Default mask=True; a mask=False evaluation is a distinct configurationtkzeng/Pangolin official source · README.md: introduction and Usage (command-line), including supported variants and --mask |
| Configuration in this record | published checkpointstkzeng/Pangolin official source · README.md: introduction and Usage (command-line), including supported variants and --mask |
| Model type | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
Schematic of the documented input, computation and output; not an executable configuration.
Pangolin uses 16 residual blocks with dilated convolutions and skip connections. Separate outputs estimate splice-site probability and usage across heart, liver, brain and testis. The published model was trained using sequence and splicing measurements from human, rhesus macaque, rat and mouse.
tkzeng/Pangolin official source · Original paper linked in README: https://doi.org/10.1186/s13059-022-02664-4, Methods: Deep neural network architecture; Results: Pangolin predicts splice site usageReference genome and transcript annotation define the sequence context. The neural predictor estimates splice-site strength; the command-line tool reports the largest positive and negative changes near each variant. Masking optionally removes particular gains and losses at annotated sites.
tkzeng/Pangolin official source · README.md: introduction and Usage (command-line), including supported variants and --maskRelease 2026-09-16-d74d282221a9 · 0 evaluations · 0 metric rows. Different protocols are not a single leaderboard.
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Primary project documentation or paper inspected for the explanatory claims and cited locations. Reviewed coverage concerns this narrative, not complete metadata, independent reproduction or a performance ranking.
Stable record: catalog-model-pangolinRelease 2026-09-16-d74d282221a9 · Record review: discovered
Stable ID: catalog-model-pangolin