benchmark · protocol

African-ancestry LCL caQTL classification (AlphaGenome paper)

Can local sequence changes predict which variants affect the measured molecular trait?

AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20

3 evaluations · 3 metric rows

At a glance

Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
Property	Description and evidence
Dataset and biological context	African-ancestry LCL caQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Split	Zero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Allowed inputs and adaptation	REF/ALT sequence and local predicted assay-signal changes. AlphaGenome DNase GM12878; Borzoi averages its two DNase GM12878 tracks.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Metrics as reported	auPRCAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Aggregation	auPRC over causal/noncausal labels.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Uncertainty	Not reported for these summary-table scores. · Not reported in inspected sourcesAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
Entity type	protocol
Organisms	Not extracted or verified for this record.
Assays	Not extracted or verified for this record.
Baselines	Not extracted or verified for this record.

How it works

African-ancestry LCL caQTL classification: evaluation procedure

Conceptual summary of the cited procedure; model-specific conditions are given below.

Read the diagram as text

Select ancestry/cell-specific QTL test set
Match the reported assay tracks
Score local REF/ALT signal change
Compute classification auPRC

What is tested

Can local sequence changes predict which variants affect the measured molecular trait?

Procedure

Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.

Tested models and results

Release 2026-09-17-a757f4af4277 · 3 evaluations · 3 metric rows. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
chrombpnet (paper Table 4): African-ancestry LCL caQTL classification Model: chrombpnet (paper Table 4) · Benchmark: African-ancestry LCL caQTL classification (AlphaGenome paper) · Dataset: African-ancestry LCL caQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review
0.414834 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels.	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L20 Source checking is not independent reproduction.
AlphaGenome distilled all-fold student: African-ancestry LCL caQTL classification Model: AlphaGenome distilled all-fold student · Benchmark: African-ancestry LCL caQTL classification (AlphaGenome paper) · Dataset: African-ancestry LCL caQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review
0.56 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels.	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M19; 'Suppl Table 4 Variant performan'!M20 Source checking is not independent reproduction.
borzoi-ensemble (paper Table 4): African-ancestry LCL caQTL classification Model: borzoi-ensemble (paper Table 4) · Benchmark: African-ancestry LCL caQTL classification (AlphaGenome paper) · Dataset: African-ancestry LCL caQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review
0.462369 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels.	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L19 Source checking is not independent reproduction.

Strengths and limitations

Strengths and considerations

No source-reviewed explanatory claims are recorded here yet.

Limitations and conditions

Proxy tracks differ across models and are part of the evaluation configuration. ChromBPNet is specialized by cell type; AlphaGenome/Borzoi are evaluated without task-label training. The inspected paper delegates detailed QTL preprocessing to ChromBPNet and does not enumerate final row-level sample counts.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20
This is an author-reported protocol, not a rewire rerun. Different datasets, processing and adaptations cannot support an unrestricted leaderboard.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20

Profile review details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Stable record: alphagenome-2026-t4-protocol-17

Evidence table

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

42 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-a757f4af4277
Property and statement	Original source and location	Review and provenance
Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims	alphagenome: Journal full-text XML Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T19:53:03.009088+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims	AlphaGenome Nature 2026 supplementary methods Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned Retrieved: 2026-09-17T06:37:01.778972+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0` Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf Inspected artifact
Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact
Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims	alphagenome: Journal full-text XML Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T19:53:03.009088+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims	AlphaGenome Nature 2026 supplementary methods Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned Retrieved: 2026-09-17T06:37:01.778972+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0` Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf Inspected artifact
Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact
Diagram title African-ancestry LCL caQTL classification: evaluation procedure Individual claims	alphagenome: Journal full-text XML Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T19:53:03.009088+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title African-ancestry LCL caQTL classification: evaluation procedure Individual claims	AlphaGenome Nature 2026 supplementary methods Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned Retrieved: 2026-09-17T06:37:01.778972+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0` Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf Inspected artifact
Diagram title African-ancestry LCL caQTL classification: evaluation procedure Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact
Dataset and biological context African-ancestry LCL caQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity. Individual claims	alphagenome: Journal full-text XML Original source ↗ 'Suppl Table 4 Variant performan'!A19:P19; 'Suppl Table 4 Variant performan'!A20:P20; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 17; sheet rows 19, 20 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied Retrieved: 2026-09-16T19:53:03.009088+00:00	source checked automated source review · 2026-09-17 Audit details Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: `attributes.profile.facts.0.value` Source artifact SHA-256: `d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

All evidence (CSV)All evidence (JSONL)How to read the evidence

Sources and history

Release 2026-09-17-a757f4af4277 · Record review: needs review

AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied

Download this release

Technical metadata and extraction receipts

Stable ID: alphagenome-2026-t4-protocol-17

areas: dna-genomes
entity level: protocol
version: Nature version of record, 28 January 2026
source evaluation index: 17
source table: 4
reference levels: metric: auPRC; printed value: 0.085209; numeric value: 8.5208999999999993E-2; source locator: Suppl Table 4 Variant performan!J19; note: Source reference quantity for relative-performance calculation, not a measured baseline run.; metric: auPRC; printed value: 0.085209; numeric value: 8.5208999999999993E-2; source locator: Suppl Table 4 Variant performan!J20; note: Source reference quantity for relative-performance calculation, not a measured baseline run.

Related records

Suggest a correction