Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
Can local sequence changes predict which variants affect the measured molecular trait?
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Dataset and biological context | Yoruba LCL dsQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Split | Zero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Allowed inputs and adaptation | REF/ALT sequence and local predicted assay-signal changes. AlphaGenome DNase GM12878; Borzoi averages its two DNase GM12878 tracks.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Metrics as reported | auPRCAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Aggregation | auPRC over causal/noncausal labels.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Uncertainty | Not reported for these summary-table scores. · Not reported in inspected sourcesAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 |
| Entity type | protocol |
| Organisms | Not extracted or verified for this record. |
| Assays | Not extracted or verified for this record. |
| Baselines | Not extracted or verified for this record. |
Conceptual summary of the cited procedure; model-specific conditions are given below.
Can local sequence changes predict which variants affect the measured molecular trait?
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24Release 2026-09-17-a757f4af4277 · 3 evaluations · 3 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| chrombpnet (paper Table 4): Yoruba LCL dsQTL classification Model: chrombpnet (paper Table 4) · Benchmark: Yoruba LCL dsQTL classification (AlphaGenome paper) · Dataset: Yoruba LCL dsQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.54317 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L24 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Yoruba LCL dsQTL classification Model: borzoi-ensemble (paper Table 4) · Benchmark: Yoruba LCL dsQTL classification (AlphaGenome paper) · Dataset: Yoruba LCL dsQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.60562 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L23 Source checking is not independent reproduction. |
| AlphaGenome distilled all-fold student: Yoruba LCL dsQTL classification Model: AlphaGenome distilled all-fold student · Benchmark: Yoruba LCL dsQTL classification (AlphaGenome paper) · Dataset: Yoruba LCL dsQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.63 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M23; 'Suppl Table 4 Variant performan'!M24 Source checking is not independent reproduction. |
No source-reviewed explanatory claims are recorded here yet.
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-t4-protocol-19Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
42 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram steps ["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Compute classification auPRC"] Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Diagram title Yoruba LCL dsQTL classification: evaluation procedure Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram title Yoruba LCL dsQTL classification: evaluation procedure Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram title Yoruba LCL dsQTL classification: evaluation procedure Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Dataset and biological context Yoruba LCL dsQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A23:P23; 'Suppl Table 4 Variant performan'!A24:P24; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 19; sheet rows 23, 24 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Release 2026-09-17-a757f4af4277 · Record review: needs review
Stable ID: alphagenome-2026-t4-protocol-19