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Coronary smooth-muscle caQTL effect-size prediction (AlphaGenome paper)

Can local sequence changes predict the direction and magnitude of measured molecular-trait effects?

AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

3 evaluations · 3 metric rows

At a glance

Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
Dataset and biological contextCoronary smooth-muscle caQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
SplitZero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
Allowed inputs and adaptationREF/ALT sequence and local predicted assay-signal changes. Track selection performed on validation data: AlphaGenome left-cardiac-atrium ATAC; Borzoi vascular-smooth-muscle ATAC.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
Metrics as reportedpearsonrAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
AggregationPearson correlation against reported effect sizes of the causal/significant QTL set.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
UncertaintyNot reported for these summary-table scores. · Not reported in inspected sourcesAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
Entity typeprotocol
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How it works

Coronary smooth-muscle caQTL effect-size prediction: evaluation procedure

Conceptual summary of the cited procedure; model-specific conditions are given below.

Coronary smooth-muscle caQTL effect-size prediction: evaluation procedureSelect ancestry/cell-specific QTL test set. Then: Match the reported assay tracks. Then: Score local REF/ALT signal change. Then: Correlate with measured effectsSelect ancestry/cell-specificQTL test setMatch the reported assay tracksScore local REF/ALT signalchangeCorrelate with measured effects
Read the diagram as text
  1. Select ancestry/cell-specific QTL test set
  2. Match the reported assay tracks
  3. Score local REF/ALT signal change
  4. Correlate with measured effects
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

What is tested

Can local sequence changes predict the direction and magnitude of measured molecular-trait effects?

AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Procedure

Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.

AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Tested models and results

Release 2026-09-17-a757f4af4277 · 3 evaluations · 3 metric rows. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
chrombpnet (paper Table 4): Coronary smooth-muscle caQTL effect-size prediction

Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.

Author-reported evaluation · Evaluation metadata: needs review

0.658407 pearsonr

Unit: correlation · Direction: higher

Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set.

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L34

Source checking is not independent reproduction.

AlphaGenome distilled all-fold student: Coronary smooth-muscle caQTL effect-size prediction

Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.

Author-reported evaluation · Evaluation metadata: needs review

0.69 pearsonr

Unit: correlation · Direction: higher

Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set.

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M33; 'Suppl Table 4 Variant performan'!M34

Source checking is not independent reproduction.

borzoi-ensemble (paper Table 4): Coronary smooth-muscle caQTL effect-size prediction

Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects.

Author-reported evaluation · Evaluation metadata: needs review

0.63039 pearsonr

Unit: correlation · Direction: higher

Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set.

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L33

Source checking is not independent reproduction.

Strengths and limitations

Strengths and considerations

No source-reviewed explanatory claims are recorded here yet.

Limitations and conditions

  • Proxy tracks differ across models and are part of the evaluation configuration. ChromBPNet is specialized by cell type; AlphaGenome/Borzoi are evaluated without task-label training. The inspected paper delegates detailed QTL preprocessing to ChromBPNet and does not enumerate final row-level sample counts.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
  • This is an author-reported protocol, not a rewire rerun. Different datasets, processing and adaptations cannot support an unrestricted leaderboard.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34
Profile review details

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Stable record: alphagenome-2026-t4-protocol-24

Evidence table

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

42 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-a757f4af4277
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual summary of the cited procedure; model-specific conditions are given below.

Individual claims
alphagenome: Journal full-text XML

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

source checked

automated source review · 2026-09-17

Audit details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram caption

Conceptual summary of the cited procedure; model-specific conditions are given below.

Individual claims
AlphaGenome Nature 2026 supplementary methods

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

source checked

automated source review · 2026-09-17

Audit details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

Diagram caption

Conceptual summary of the cited procedure; model-specific conditions are given below.

Individual claims
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

source checked

automated source review · 2026-09-17

Audit details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

Hash scope: SHA-256 of exact retrieved original artifact bytes

Format: xlsx

Inspected artifact

Diagram steps

["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Correlate with measured effects"]

Individual claims
alphagenome: Journal full-text XML

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

source checked

automated source review · 2026-09-17

Audit details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Diagram steps

["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Correlate with measured effects"]

Individual claims
AlphaGenome Nature 2026 supplementary methods

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

source checked

automated source review · 2026-09-17

Audit details

Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

Diagram steps

["Select ancestry/cell-specific QTL test set","Match the reported assay tracks","Score local REF/ALT signal change","Correlate with measured effects"]

Individual claims
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

source checked

automated source review · 2026-09-17

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Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

Hash scope: SHA-256 of exact retrieved original artifact bytes

Format: xlsx

Inspected artifact

Diagram title

Coronary smooth-muscle caQTL effect-size prediction: evaluation procedure

Individual claims
alphagenome: Journal full-text XML

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

source checked

automated source review · 2026-09-17

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Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.

Field: attributes.profile.diagram.title

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

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Format: original_artifact

Inspected artifact

Diagram title

Coronary smooth-muscle caQTL effect-size prediction: evaluation procedure

Individual claims
AlphaGenome Nature 2026 supplementary methods

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

source checked

automated source review · 2026-09-17

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Field: attributes.profile.diagram.title

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

Diagram title

Coronary smooth-muscle caQTL effect-size prediction: evaluation procedure

Individual claims
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

source checked

automated source review · 2026-09-17

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Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

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Format: xlsx

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Dataset and biological context

Coronary smooth-muscle caQTL data reused from the ChromBPNet evaluation; retain this ancestry/cell-type/trait identity.

Individual claims
alphagenome: Journal full-text XML

Original source ↗

'Suppl Table 4 Variant performan'!A33:P33; 'Suppl Table 4 Variant performan'!A34:P34; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods pp.36–37, Chromatin accessibility variants & bQTLs; methods: pp.36–37, Chromatin accessibility variants & bQTLs; paper: Sec10; Fig.5a–c; Supplementary Fig.9; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 24; sheet rows 33, 34

Shared locator for this statement’s cited sources; not a separate locator for each citation.

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Retrieved: 2026-09-16T19:53:03.009088+00:00

source checked

automated source review · 2026-09-17

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Field: attributes.profile.facts.0.value

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Sources and history

Release 2026-09-17-a757f4af4277 · Record review: needs review

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Technical metadata and extraction receipts

Stable ID: alphagenome-2026-t4-protocol-24

areas
dna-genomes
entity level
protocol
version
Nature version of record, 28 January 2026
source evaluation index
24
source table
4
reference levels
metric: pearsonr; printed value: 0; numeric value: 0; source locator: Suppl Table 4 Variant performan!J33; note: Source reference quantity for relative-performance calculation, not a measured baseline run.; metric: pearsonr; printed value: 0; numeric value: 0; source locator: Suppl Table 4 Variant performan!J34; note: Source reference quantity for relative-performance calculation, not a measured baseline run.
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