Strengths and considerations
- Measured affinities provide a quantitative endpoint when assays are comparable.Boltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extracted
benchmark · task
Small-molecule affinity
How strongly does a molecule bind its target under the measured conditions?
At a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.
| Property | Description and evidence |
|---|---|
| Record type | Generic task; proposed designBoltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extracted |
| Inputs | Predict measured binding affinity; pose confidence is not an affinity value.Boltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extracted |
| Assessment | No single dataset, split or scoring implementation is fixed by this task recordBoltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extracted |
| Datasets | Not extracted or verified for this record. |
| Organisms | Not extracted or verified for this record. |
| Assays | Not extracted or verified for this record. |
| Splits | Not extracted or verified for this record. |
| Adaptation | Not extracted or verified for this record. |
| Baselines | Not extracted or verified for this record. |
How it works
Conceptual design only. This generic task has no fixed executable protocol and does not imply a completed run.
Read the diagram as text
- Choose affinity assay
- Define compound and target split
- Predict binding strength
- Compare matched affinity units
Proposed comparison design
Select a defined affinity assay and unit, separate compounds and targets according to the intended transfer test, and record any structural information supplied.
Boltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extractedTested models and results
Release 2026-09-16-d74d282221a9 · 0 evaluations · 0 metric rows. Different protocols are not a single leaderboard.
No evaluations linked in this release.
Strengths and limitations
Limitations and conditions
- A pose-confidence score is not an affinity; Kd, Ki and activity measurements must not be silently combined.Boltz-2 official resource · Catalogue task scope and proposed comparison design; concrete source protocol has not yet been extracted
Profile review details
Catalogue extraction inspected; protocol claims remain limited to the cited evidence. Missing details are not presumed absent from the original paper.
Stable record: catalog-task-ligand-affinitySources and history
Release 2026-09-16-d74d282221a9 · Record review: discovered
- Boltz-2 official resource · Original source · Not reported
Technical metadata and extraction receipts
Stable ID: catalog-task-ligand-affinity
- areas
- molecular-interactions
- entity level
- task
- version
- Not reported
- task
- Small-molecule affinity
- scope note
- Predict measured binding affinity; pose confidence is not an affinity value.
- missing metadata
- protocol version: not_yet_extracted