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FLIP2

FLIP2 extends protein fitness evaluation to additional engineering settings.

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At a glance

Explanatory profile: source reviewed · Automated source review, 2026-09-16. This does not change the review status of its results.

Data, procedure and scoring
PropertyDescription and evidence
Record typeDataset and split suiteflip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types
InputsProtein variant sequences and measured propertiesflip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types
Outputs and assessmentFitness prediction under explicit distribution shiftsflip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types
DatasetsNot extracted or verified for this record.
OrganismsNot extracted or verified for this record.
AssaysNot extracted or verified for this record.
SplitsNot extracted or verified for this record.
AdaptationNot extracted or verified for this record.
BaselinesNot extracted or verified for this record.

How it works

Procedure overview

Conceptual overview of the cited procedure; consult the pinned source for executable settings.

Procedure overviewChoose engineering shift. Then: Fit allowed predictor. Then: Predict held-out variants. Then: Compare measured fitnessChoose engineering shiftFit allowed predictorPredict held-out variantsCompare measured fitness
Read the diagram as text
  1. Choose engineering shift
  2. Fit allowed predictor
  3. Predict held-out variants
  4. Compare measured fitness
flip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types

Procedure

Use a released split testing mutation count, position, unseen mutations, fitness range or wild-type transfer. Compare zero-shot models, ridge regression and fine-tuned predictors under the same split.

flip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types

Tested models and results

Release 2026-09-16-d74d282221a9 · 0 evaluations · 0 metric rows. Different protocols are not a single leaderboard.

No evaluations linked in this release.

Strengths and limitations

Strengths supported by sources

  • Includes simple regression baselines and several practical transfer settings.flip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types

Limitations and conditions

  • Split difficulty changes the question being asked; aggregate rankings do not identify a universal protein engineering method.flip2 official source · Official FLIP2 site: Abstract; Key Features; Overview; Split Types
Profile review details

Primary-source description checked by an automated research assistant. This is a profile review, not an independent execution or numerical reproduction.

Stable record: discovery-benchmark-flip2

Sources and history

Release 2026-09-16-d74d282221a9 · Record review: discovered

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Technical metadata and extraction receipts

Stable ID: discovery-benchmark-flip2

areas
protein-function
entity level
suite
missing metadata
dataset release: unextracted; metric implementation: unextracted; split manifest: unextracted; version: unextracted
scope note
Specialist molecular or omics evaluation; protocol details require review before numerical comparison.
task
Expanded protein fitness landscapes
version
Not reported
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