rewire.itbenchmarks
Dataset subset

MFASS v2 test: matched canonical annotation coverage

8,297 of 8,324 held-out variants scored in every configuration (314 positives, 460 exon groups). The same 27 rows are excluded: 23 assembly-orientation mismatches and four outside the selected canonical transcript spans. Missing scores are not zero or negative predictions.

Evaluation results

4 evaluations · 16 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask False (P0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.876 AUROC
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask False (P0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P0.metrics.auroc
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask False (P0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.389 Average precision
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask False (P0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P0.metrics.average_precision_sklearn
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask False (P0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.65 Precision at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask False (P0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P0.metrics.precision_at_capacity
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask False (P0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.207 Recall at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask False (P0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P0.metrics.recall_at_capacity
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask True (P1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.873 AUROC
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask True (P1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P1.metrics.auroc
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask True (P1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.411 Average precision
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask True (P1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P1.metrics.average_precision_sklearn
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask True (P1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.66 Precision at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask True (P1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P1.metrics.precision_at_capacity
Configuration: Pangolin 1.0.2 + per-gene masking patch · mask True (P1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.21 Recall at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

Pangolin 1.0.2 + per-gene masking patch · mask True (P1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.P1.metrics.recall_at_capacity
Configuration: SpliceAI 1.3.1 · mask 0 (S0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.804 AUROC
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 0 (S0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S0.metrics.auroc
Configuration: SpliceAI 1.3.1 · mask 0 (S0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.295 Average precision
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 0 (S0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S0.metrics.average_precision_sklearn
Configuration: SpliceAI 1.3.1 · mask 0 (S0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.63 Precision at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 0 (S0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S0.metrics.precision_at_capacity
Configuration: SpliceAI 1.3.1 · mask 0 (S0)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.201 Recall at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 0 (S0) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S0.metrics.recall_at_capacity
Configuration: SpliceAI 1.3.1 · mask 1 (S1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.815 AUROC
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 1 (S1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S1.metrics.auroc
Configuration: SpliceAI 1.3.1 · mask 1 (S1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.313 Average precision
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 1 (S1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S1.metrics.average_precision_sklearn
Configuration: SpliceAI 1.3.1 · mask 1 (S1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.65 Precision at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 1 (S1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S1.metrics.precision_at_capacity
Configuration: SpliceAI 1.3.1 · mask 1 (S1)Protocol: MFASS: matched GENCODE 44 canonical annotation
Dataset subset: MFASS v2 test: matched canonical annotation coverage
0.207 Recall at 100
dimensionless · higher

Uncertainty: Not reported

Coverage: 8297/8324

Rewire evaluation · Source checked
Methods, coverage and source

SpliceAI 1.3.1 · mask 1 (S1) on MFASS matched annotation

MFASS matched GENCODE 44 canonical annotation

Aggregation: Not reported

MFASS matched canonical annotation v1: report.json; MFASS matched canonical annotation v1: manifest-v1.json; MFASS matched canonical annotation v1: verification.json; MFASS matched canonical annotation v1: provenance.json; MFASS matched canonical annotation v1: exclusion-verification.json · report.json: conditions.S1.metrics.recall_at_capacity

Source checking is not independent reproduction. Release 2026-09-25-d40cee0abe73.

Subset and evaluation context

This record describes a particular subset or cohort used in an evaluation. Its results do not describe the full dataset.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

70 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-25-d40cee0abe73
Property and statementOriginal source and locationReview and provenance
attributes.exclusion_counts.assembly_orientation
23
Context-only references
MFASS matched canonical annotation v1: exclusion-verification.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 4be7a98e2553fa2378c29625b13eb3e8ac2e58fb
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.assembly_orientation

Source artifact SHA-256: 5d2099db4cf6f01432fd88c7db949da89ab9917940705fd0eaa1fb7c9354d46a

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.assembly_orientation
23
Context-only references
MFASS matched canonical annotation v1: manifest-v1.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.assembly_orientation

Source artifact SHA-256: 3fce70dd0bd96cb92d9d0e41287f31e62ddc4ecb8d188615093a873e952433e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.assembly_orientation
23
Context-only references
MFASS matched canonical annotation v1: provenance.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.assembly_orientation

Source artifact SHA-256: 6304e9625e793f24cccdc2669d092e6cdcc7a508a7f789967e726816fffde062

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.assembly_orientation
23
Context-only references
MFASS matched canonical annotation v1: report.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.assembly_orientation

Source artifact SHA-256: 259eb542313914b9114c21b62891f022c0ec0d9e3337196b8d7b2c6d5ae54ef3

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.assembly_orientation
23
Context-only references
MFASS matched canonical annotation v1: verification.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.assembly_orientation

Source artifact SHA-256: 13356c3f1bd7055b11cc0ab1b2b86a7ee586c51d0c984fad6e39ce8948d662fa

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.canonical_transcript_span
4
Context-only references
MFASS matched canonical annotation v1: exclusion-verification.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 4be7a98e2553fa2378c29625b13eb3e8ac2e58fb
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.canonical_transcript_span

Source artifact SHA-256: 5d2099db4cf6f01432fd88c7db949da89ab9917940705fd0eaa1fb7c9354d46a

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.canonical_transcript_span
4
Context-only references
MFASS matched canonical annotation v1: manifest-v1.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.canonical_transcript_span

Source artifact SHA-256: 3fce70dd0bd96cb92d9d0e41287f31e62ddc4ecb8d188615093a873e952433e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.canonical_transcript_span
4
Context-only references
MFASS matched canonical annotation v1: provenance.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.canonical_transcript_span

Source artifact SHA-256: 6304e9625e793f24cccdc2669d092e6cdcc7a508a7f789967e726816fffde062

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.canonical_transcript_span
4
Context-only references
MFASS matched canonical annotation v1: report.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.canonical_transcript_span

Source artifact SHA-256: 259eb542313914b9114c21b62891f022c0ec0d9e3337196b8d7b2c6d5ae54ef3

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.exclusion_counts.canonical_transcript_span
4
Context-only references
MFASS matched canonical annotation v1: verification.json

Original source ↗

report.json: coverage and contrasts; computational exclusion verification

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 093fd1ae198c80ce34408d84d6543bca4fc538f2
Retrieved: 2026-09-25T11:24:56Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.exclusion_counts.canonical_transcript_span

Source artifact SHA-256: 13356c3f1bd7055b11cc0ab1b2b86a7ee586c51d0c984fad6e39ce8948d662fa

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-25-d40cee0abe73 · Record review: source checked

5 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: rewire-mfass-matched-v1-dataset

areas
dna-genomes
version
split-v2-matched-annotation-v1
test count
8324
scored count
8297
missing count
27
positive count
314
independent groups
460
scored ids sha256
89b5568e2d819b892ba5e6db680d85e41224d6a69fec4b09a85c5075cade39d8
exclusion counts
assembly orientation: 23; canonical transcript span: 4
exclusion issue url
https://github.com/KosuriLab/MFASS/issues/1
source locator
report.json: coverage and contrasts; computational exclusion verification
limitations
8,297 of 8,324 held-out variants scored in every configuration (314 positives, 460 exon groups). The same 27 rows are excluded: 23 assembly-orientation mismatches and four outside the selected canonical transcript spans. Missing scores are not zero or negative predictions.; Exploratory comparison: prior results were known. Paired contrast intervals are unadjusted and do not establish a universal model ranking.; Pangolin uses the recorded per-gene masking patch; these are exact configurations, not unqualified upstream model scores.; Precision at 100 is sensitive to tied-score ordering, especially P1. Numerical source checking is automated, not human review or independent reproduction.; Assembly-orientation issue reported at https://github.com/KosuriLab/MFASS/issues/1. Original v1 outputs remain unchanged; corrections require a new version.
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