AlphaGenome fold-1 splice-site-usage model: Human splice-site usage
Correlate predicted and measured usage over held-out splice-site positions for each tissue track.
Evaluation procedure
Correlate predicted and measured usage over held-out splice-site positions for each tissue track.
- Model
- AlphaGenome fold-1 splice-site-usage model
- Benchmark
- Human splice-site usage (AlphaGenome paper)
- Dataset
- Human splice-site usage: evaluated data subset
- origin
- Author-reported evaluation
- configuration
- AlphaGenome fold-1 splice-site-usage model
- protocol id
- alphagenome-2026-t3-protocol-3
- dataset version
- Not reported
- split
- The same fold-1 held-out intervals used for comparative splice-site evaluation.
- population
- RNA-seq-derived splice-site usage values from the filtered junction dataset.
- inputs
- Not reported
- adaptation
- AlphaGenome fold-1 splice-site-usage model
- metric implementation
- Not reported
- aggregation
- Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting.
- budget
- Not reported
Metadata review: needs review. Unreported conditions prevent automatic comparisons.
Evaluation results
Release 2026-09-17-a757f4af4277 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| AlphaGenome fold-1 splice-site-usage model: Human splice-site usage Model: AlphaGenome fold-1 splice-site-usage model · Benchmark: Human splice-site usage (AlphaGenome paper) · Dataset: Human splice-site usage: evaluated data subset Correlate predicted and measured usage over held-out splice-site positions for each tissue track. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.86 pearsonr Unit: correlation · Direction: higher Aggregation: Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K6; 'Suppl Table 3 Track performance'!K7 Source checking is not independent reproduction. |
Evidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
63 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.comparison.adaptation AlphaGenome fold-1 splice-site-usage model Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.adaptation AlphaGenome fold-1 splice-site-usage model Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.adaptation AlphaGenome fold-1 splice-site-usage model Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.aggregation Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting. Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.aggregation Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting. Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.aggregation Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting. Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.budget No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.dataset_version No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-evaluation-4dd348bb36f3f9ba
- areas
- dna-genomes
- origin
- author_reported
- protocol
- Correlate predicted and measured usage over held-out splice-site positions for each tissue track.
- version
- AlphaGenome fold-1 splice-site-usage model
- source evaluation index
- 3
- source table
- 3
- comparison
- protocol id: alphagenome-2026-t3-protocol-3; dataset version: Not reported; split: The same fold-1 held-out intervals used for comparative splice-site evaluation.; population: RNA-seq-derived splice-site usage values from the filtered junction dataset.; inputs: Not reported; adaptation: AlphaGenome fold-1 splice-site-usage model; metric implementation: Not reported; aggregation: Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting.; budget: Not reported
- context
- allowed inputs: Reference DNA and tissue-specific predicted splice-site usage; compare DeltaSplice and SpliceAI as listed in Table3.; limitations: Different definitions of site usage prevent a like-for-like Pangolin usage-head comparison; no universal usage metric is implied.
- missing metadata
- dataset version: unextracted; exact input manifest: unextracted; inference budget: unreported; scoring failures: unreported