Pangolin (paper Table 4): Author MFASS splice-disruption prediction
Use the MFASS-specific donor/acceptor and junction scoring procedure, sum splicing components, then average across tissues. Compare with the source’s exon-inclusion disruption label.
Evaluation procedure
Use the MFASS-specific donor/acceptor and junction scoring procedure, sum splicing components, then average across tissues. Compare with the source’s exon-inclusion disruption label.
- Model
- Pangolin (paper Table 4)
- Benchmark
- Author MFASS splice-disruption prediction (AlphaGenome paper)
- Dataset
- Author MFASS splice-disruption prediction: evaluated data subset
- origin
- Author-reported evaluation
- configuration
- Pangolin (paper Table 4)
- protocol id
- alphagenome-2026-t4-protocol-7
- dataset version
- Not reported
- split
- Zero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.
- population
- MFASS reporter-assay SNVs processed using the MMSplice-paper MFASS notebook; mislabelled strands removed. The paper’s cleaned-dataset totals are not a reported test-subset count.
- inputs
- Not reported
- adaptation
- Pangolin (paper Table 4)
- metric implementation
- Not reported
- aggregation
- auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold.
- budget
- Not reported
Metadata review: needs review. Unreported conditions prevent automatic comparisons.
Evaluation results
Release 2026-09-17-a757f4af4277 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| Pangolin (paper Table 4): Author MFASS splice-disruption prediction Model: Pangolin (paper Table 4) · Benchmark: Author MFASS splice-disruption prediction (AlphaGenome paper) · Dataset: Author MFASS splice-disruption prediction: evaluated data subset Use the MFASS-specific donor/acceptor and junction scoring procedure, sum splicing components, then average across tissues. Compare with the source’s exon-inclusion disruption label. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.541972 all_tissues_auprc Unit: dimensionless · Direction: higher Aggregation: auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L8 Source checking is not independent reproduction. |
Evidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
63 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.comparison.adaptation Pangolin (paper Table 4) Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.adaptation Pangolin (paper Table 4) Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.adaptation Pangolin (paper Table 4) Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.aggregation auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold. Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.aggregation auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold. Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.aggregation auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold. Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.budget No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.dataset_version No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-evaluation-e7303a8d4724727f
- areas
- dna-genomes
- origin
- author_reported
- protocol
- Use the MFASS-specific donor/acceptor and junction scoring procedure, sum splicing components, then average across tissues. Compare with the source’s exon-inclusion disruption label.
- version
- Pangolin (paper Table 4)
- source evaluation index
- 7
- source table
- 4
- comparison
- protocol id: alphagenome-2026-t4-protocol-7; dataset version: Not reported; split: Zero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.; population: MFASS reporter-assay SNVs processed using the MMSplice-paper MFASS notebook; mislabelled strands removed. The paper’s cleaned-dataset totals are not a reported test-subset count.; inputs: Not reported; adaptation: Pangolin (paper Table 4); metric implementation: Not reported; aggregation: auPRC for the splice-disrupting label defined by the MFASS exon-inclusion threshold.; budget: Not reported
- context
- allowed inputs: REF/ALT sequence, the assayed exon’s donor/acceptor identity and paper-specific splicing-head scores.; limitations: This is the author’s MFASS analysis, not rewire MFASS v2. The methods first prescribe logits, then describe probability/usage differences; do not silently reconstruct an exact scorer implementation from this wording. Do not assign cleaned full-dataset counts to its held-out test subset.
- missing metadata
- dataset version: unextracted; exact input manifest: unextracted; inference budget: unreported; scoring failures: unreported