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Evaluation

CPA* on PerturBench CB-COSINE: combination prediction on Norman19, Cosine similarity of log fold change

PerturBench evaluation of CPA* on combination prediction on Norman19, Cosine similarity of log fold change, scored with Cosine similarity of log fold change.

Methods and reproduction

PerturBench evaluation of CPA* on combination prediction on Norman19, Cosine similarity of log fold change, scored with Cosine similarity of log fold change.

task
PerturBench CB-COSINE: combination prediction on Norman19, Cosine similarity of log fold change
configuration
CPA*
dataset subset
Norman19 (PerturBench split)
Split
Not reported
Adaptation
Not reported
Scoring implementation
Cosine similarity of log fold change

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evaluation procedure

Predict the effect of a pair of gene overexpressions from single perturbations, reported as the mean and one standard deviation over seeds.

Configuration
CPA*
Task
PerturBench CB-COSINE: combination prediction on Norman19, Cosine similarity of log fold change
Dataset subset
Norman19 (PerturBench split)
origin
Author-reported evaluation
configuration
Not reported
protocol id
perturbench-task-cb-cosine
metric implementation
Cosine similarity of log fold change

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Evaluation results

Release 2026-09-17-134cd1815de8 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard. Where several source tables report the same metric, the published comparisons above offer a pooled view that names what it does not hold constant.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
CPA* on PerturBench CB-COSINE: combination prediction on Norman19, Cosine similarity of log fold change

Predict the effect of a pair of gene overexpressions from single perturbations, reported as the mean and one standard deviation over seeds.

Author-reported evaluation · Evaluation metadata: source checked

0.52 ± 6 × 10 − 2 cosine_logfc

Unit: fraction · Direction: higher

Uncertainty: type: standard deviation; value: 0.06

Scored: Not reported · Eligible: Not reported

source checkedPerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis · Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Source checking is not independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

10 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-134cd1815de8
Property and statementOriginal source and locationReview and provenance
attributes.comparison.metric_implementation

Cosine similarity of log fold change

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.protocol_id

perturbench-task-cb-cosine

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.origin

author_reported

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.protocol

Predict the effect of a pair of gene overexpressions from single perturbations, reported as the mean and one standard deviation over seeds.

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.protocol

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.source_locator

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

description

PerturBench evaluation of CPA* on combination prediction on Norman19, Cosine similarity of log fold change, scored with Cosine similarity of log fold change.

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: description

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: benchmark

perturbench-task-cb-cosine

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: links:benchmark:perturbench-task-cb-cosine

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: dataset

perturbench-dataset-norman19

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: links:dataset:perturbench-dataset-norman19

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Relationship: model

perturbench-method-cpa

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: links:model:perturbench-method-cpa

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

name

CPA* on PerturBench CB-COSINE: combination prediction on Norman19, Cosine similarity of log fold change

Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis

Original source ↗

Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))

Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Retrieved: 2026-09-17T08:06:28.400469+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: name

Source artifact SHA-256: 5c4804565dd9faa17a11853a79e9847dcb6da73715b4c91f62e5b274cc79f186

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Sources and history

Release 2026-09-17-134cd1815de8 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: perturbench-evaluation-cpa-cb-cosine

areas
cells-tissues
tasks
combination prediction on Norman19, Cosine similarity of log fold change
origin
author_reported
protocol
Predict the effect of a pair of gene overexpressions from single perturbations, reported as the mean and one standard deviation over seeds.
comparison
protocol id: perturbench-task-cb-cosine; metric implementation: Cosine similarity of log fold change
missing metadata
checkpoint revision: unreported; seeds: unreported; budget: unreported; split manifest: unextracted
source locator
Table 3, row(CPA ∗), column(Cosine, log fold change (LogFC))
Related records

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