Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
model · method
SpliceAI (paper Table 3)
SpliceAI (paper Table 3). A comparator reported by the AlphaGenome authors; protocol pages specify the dataset and adaptation.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site ClassificationAt a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Reported method | SpliceAIAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification |
| Exact checkpoint | Not established by the summary table; inspect the protocol and original implementation. · Needs further source reviewAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification |
| Model type | Not extracted or verified for this record. |
| Inputs | Not extracted or verified for this record. |
| Outputs | Not extracted or verified for this record. |
| Parameters | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
How it works
How this comparator was evaluated
The source table identifies SpliceAI. Compare probabilities with the selected binary splice-site labels at genomic positions.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site ClassificationBenchmarks and results
Release 2026-09-17-a757f4af4277 · 3 evaluations · 3 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| SpliceAI (paper Table 3): Human splice-site classification: RNA-derived Model: SpliceAI (paper Table 3) · Benchmark: Human splice-site classification: RNA-derived (AlphaGenome paper) · Dataset: Human splice-site classification: RNA-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.755 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J2 Source checking is not independent reproduction. |
| SpliceAI (paper Table 3): Human splice-site usage Model: SpliceAI (paper Table 3) · Benchmark: Human splice-site usage (AlphaGenome paper) · Dataset: Human splice-site usage: evaluated data subset Correlate predicted and measured usage over held-out splice-site positions for each tissue track. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.769 pearsonr Unit: correlation · Direction: higher Aggregation: Per-tissue Pearson correlation; the table provides an aggregate scalar but this task paragraph does not explicitly define its cross-tissue weighting. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J7 Source checking is not independent reproduction. |
| SpliceAI (paper Table 3): Human splice-site classification: annotation-derived Model: SpliceAI (paper Table 3) · Benchmark: Human splice-site classification: annotation-derived (AlphaGenome paper) · Dataset: Human splice-site classification: annotation-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.815 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J4 Source checking is not independent reproduction. |
Strengths and limitations
Limitations and conditions
- A table label does not establish identity with any other catalogue configuration bearing the same name.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification
Profile review details
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-comparator-9f73332b9e8ed9a8Evidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
15 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported method SpliceAI Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Reported method SpliceAI Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Reported method SpliceAI Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| How this comparator was evaluated The source table identifies SpliceAI. Compare probabilities with the selected binary splice-site labels at genomic positions. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; Supplementary Methods p.22, Splice Site Classification Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-comparator-9f73332b9e8ed9a8
- areas
- dna-genomes
- entity level
- method
- configuration type
- reported_configuration
- version
- SpliceAI (paper Table 3)