Model type
Sequence-to-structure protein prediction pipeline
ESMFold predicts protein structures directly from amino-acid sequence using ESM-2 representations.
Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.
Sequence-to-structure protein prediction pipeline
Protein amino-acid sequence; the ESMFold interface also accepts chains separated by a colon.
Predicted PDB structure and confidence values.
Official project documentation and implementation: https://github.com/facebookresearch/esm
limited source coverage · Automated source review, 2026-09-16. All specifications and missing details
14 evaluations · 14 metric rows. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-GDT-TS-MEAN: Accuracy GDT-TS (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.826 gdt-ts_mean score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-GDT-TS-MEAN: Accuracy GDT-TS (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy GDT-TS ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-GDT-TS-MEDIAN: Accuracy GDT-TS (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.881 gdt-ts_median score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-GDT-TS-MEDIAN: Accuracy GDT-TS (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy GDT-TS ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-LDDT-MEAN: Accuracy lDDT (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.870 lddt_mean score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-LDDT-MEAN: Accuracy lDDT (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy lDDT ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-LDDT-MEDIAN: Accuracy lDDT (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.907 lddt_median score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-LDDT-MEDIAN: Accuracy lDDT (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy lDDT ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-RMSD-MEAN: Accuracy RMSD (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 3.98 rmsd_mean score · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-RMSD-MEAN: Accuracy RMSD (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy RMSD ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-RMSD-MEDIAN: Accuracy RMSD (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 2.10 rmsd_median score · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-RMSD-MEDIAN: Accuracy RMSD (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy RMSD ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-TM-SCORE-MEAN: Accuracy TM-score (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.847 tm-score_mean score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-TM-SCORE-MEAN: Accuracy TM-score (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy TM-score ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-ACCURACY-TM-SCORE-MEDIAN: Accuracy TM-score (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.929 tm-score_median score · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-ACCURACY-TM-SCORE-MEDIAN: Accuracy TM-score (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Accuracy TM-score ↑) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-CA-BREAK-MEAN: Quality CA break (%) (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.0% ca-break_mean percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-CA-BREAK-MEAN: Quality CA break (%) (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality CA break (%) ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-CA-BREAK-MEDIAN: Quality CA break (%) (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.0% ca-break_median percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-CA-BREAK-MEDIAN: Quality CA break (%) (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality CA break (%) ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-CA-CLASH-MEAN: Quality CA clash (%) (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.3% ca-clash_mean percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-CA-CLASH-MEAN: Quality CA clash (%) (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality CA clash (%) ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-CA-CLASH-MEDIAN: Quality CA clash (%) (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 0.0% ca-clash_median percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-CA-CLASH-MEDIAN: Quality CA clash (%) (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality CA clash (%) ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-PEPBOND-BREAK-MEAN: Quality PepBond break (%) (mean) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 4.7% pepbond-break_mean percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-PEPBOND-BREAK-MEAN: Quality PepBond break (%) (mean) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality PepBond break (%) ↓) |
| Configuration: ESMFold | Task: ProteinBench FOLD-QUALITY-PEPBOND-BREAK-MEDIAN: Quality PepBond break (%) (median) Dataset subset: CAMEO2022, 183 proteins (ProteinBench split) | 3.4% pepbond-break_median percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · source checkedMethods, coverage and sourceESMFold on ProteinBench FOLD-QUALITY-PEPBOND-BREAK-MEDIAN: Quality PepBond break (%) (median) Structure prediction on CAMEO2022. Each cell prints the mean and the median over 183 proteins. Aggregation: Not reported proteinbench primary benchmark evidence · Table 7, row(ESMFold), column(Quality PepBond break (%) ↓) |
Source checking is not independent reproduction. Release 2026-09-23-2b89723c6dd9.
Related profile: ESMFold. This page retains the exact record and its evaluation context.
ESMFold predicts protein structures directly from amino-acid sequence using ESM-2 representations. ESM-2 sequence representations feed a folding trunk and structure module. The checked v1 configuration has 48 trunk blocks, eight structure-module blocks and up to four recycles. The documented inputs are protein amino-acid sequence; the ESMFold interface also accepts chains separated by a colon. The output consists of predicted PDB structure and confidence values.
esmfold_v0 and esmfold_v1; v1 is the repository recommendation. Inference length is constrained by memory; the repository documents chunking and CPU offload. Backbone position settings do not alone establish the full folding pipeline limit.
Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.
Stable record: catalog-model-esmfoldExplanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Model type | Sequence-to-structure protein prediction pipelineSources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Architecture | ESM-2 sequence representations feed a folding trunk and structure module. The checked v1 configuration has 48 trunk blocks, eight structure-module blocks and up to four recycles.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Inputs | Protein amino-acid sequence; the ESMFold interface also accepts chains separated by a colon.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Outputs | Predicted PDB structure and confidence values.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Parameters | The released v1 configuration identifies an ESM-2 3B backbone plus a folding trunk and structure module. The 3B figure is not the total size of the complete predictor.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Known versions | esmfold_v0 and esmfold_v1; v1 is the repository recommendation.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Training data | PDB and UniRef50 are listed for ESMFold. Full structural training-cutoff verification remains outstanding.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Training cutoff | PDB and UniRef50 are identified in the official model table; the inspected ESMFold-v1 card and configuration do not supply a shared latest-data date for both components. · Not reported in inspected sourcesSources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Context limits | Inference length is constrained by memory; the repository documents chunking and CPU offload. Backbone position settings do not alone establish the full folding pipeline limit.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Weights licence | MIT declared by the official facebook/esmfold_v1 model card.Sources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Access | Official project documentation and implementation: https://github.com/facebookresearch/esmSources (3)facebookresearch/esm: README.md; facebook/esmfold_v1: README.md; facebook/esmfold_v1: config.json · ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config |
| Code licence | MITSourcesfacebookresearch/esm: LICENSE · LICENSE: licence text |
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
59 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims | facebookresearch/esm: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims | facebook/esmfold_v1: config.json ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims | facebook/esmfold_v1: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Diagram steps
| facebookresearch/esm: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Diagram steps
| facebook/esmfold_v1: config.json ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Diagram steps
| facebook/esmfold_v1: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram title ESMFold workflow Individual claims | facebookresearch/esm: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram title ESMFold workflow Individual claims | facebook/esmfold_v1: config.json ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram title ESMFold workflow Individual claims | facebook/esmfold_v1: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 75a3841ee059df2bf4d56688166c8fb459ddd97a | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Model type Sequence-to-structure protein prediction pipeline Individual claims | facebookresearch/esm: README.md ESM README: ESMFold Structure Prediction; official facebook/esmfold_v1 model card and config.json esmfold_config Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | source checked automated source review · 2026-09-16 Audit detailsInspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
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Release 2026-09-23-2b89723c6dd9 · Record review: discovered
Stable ID: catalog-model-esmfold