Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
model · method
ESM-2
ESM-2 is the method recorded for Zero-shot substitution mutation effects: stability. This page preserves the configuration reported by ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction.
At a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.
| Property | Description and evidence |
|---|---|
| Recorded dataset | ProteinGym substitution DMS: stability assaysProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability column |
| Recorded configuration | 15BProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability column |
| Model type | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
How it works
Recorded evaluation
The imported evaluation describes this procedure: Zero-shot mutation scores; average Spearman across stability-category assays.
ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability columnBenchmarks and results
Release 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESM-2: Zero-shot substitution mutation effects: stability Model: ESM-2 · Benchmark: Zero-shot substitution mutation effects: stability · Dataset: ProteinGym substitution DMS: stability assays Zero-shot mutation scores; average Spearman across stability-category assays. Independent external evaluation · Evaluation metadata: needs review | ||
| 0.488 Mean Spearman rho Unit: unitless · Direction: unknown | Uncertainty: not reported in legacy extract Scored: Not reported · Eligible: Not reported | source checkedProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability column Source checking is not independent reproduction. |
Strengths and limitations
Limitations and conditions
- This is an evidence-limited profile. The recorded evaluation context does not establish performance on other datasets or configurations.ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability column
Profile review details
Reviewed the existing release record, its source pointer and linked evaluation context. This is not a fresh full-text architecture review or independent reproduction; numerical review status is unchanged.
Stable record: reported-model-d326e3c4e3ba20Sources and history
Release 2026-09-16-d74d282221a9 · Record review: needs review
- ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Original source · PMC10723403.1
Technical metadata and extraction receipts
Stable ID: reported-model-d326e3c4e3ba20
- areas
- proteins-complexes
- entity level
- method
- version
- 15B
- reported name
- ESM-2
- missing metadata
- checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract