Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
Pipeline
borzoi-ensemble: variant scores + random forest (paper Table 4)
borzoi-ensemble: variant scores + random forest (paper Table 4). A comparator reported by the AlphaGenome authors; protocol pages specify the dataset and adaptation.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causalityAt a glance
Key specifications have not been extracted for this record. See the linked evaluation and sources for the reported setup.
limited source coverage · Automated source review, 2026-09-17. All specifications and missing details
Evaluations and results
Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| borzoi-ensemble: variant scores + random forest (paper Table 4): Supervised distance-balanced eQTL causality Pipeline: borzoi-ensemble: variant scores + random forest (paper Table 4)Protocol: Supervised distance-balanced eQTL causality (AlphaGenome paper)Dataset subset: Supervised distance-balanced eQTL causality: evaluated data subset Train the source’s random-forest classifier on the same balanced causality dataset and score the held-out chromosome test set. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.759224069094061 tissue_weighted_mean_auroc Unit: dimensionless · Direction: higher Aggregation: auROC per tissue weighted by the tissue’s variant count; the supervised analysis additionally averages auROC across five fitted folds. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L14 Source checking is not independent reproduction. |
How it works
How this comparator was evaluated
The source table identifies borzoi-ensemble. Train the source’s random-forest classifier on the same balanced causality dataset and score the held-out chromosome test set.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causalityStrengths and limitations
Limitations and conditions
- A table label does not establish identity with any other catalogue configuration bearing the same name.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality
Profile review details
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-comparator-ce0c8666036db12eSpecifications
Inputs, training, access and other details
Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Reported method | borzoi-ensembleSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality |
| Exact checkpoint | Not established by the summary table; inspect the protocol and original implementation. · Needs further source reviewSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality |
| Inputs | Not extracted or verified for this record. |
| Outputs | Not extracted or verified for this record. |
| Adaptation | Not extracted or verified for this record. |
| Implementation | Not extracted or verified for this record. |
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
15 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported method borzoi-ensemble Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Reported method borzoi-ensemble Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Reported method borzoi-ensemble Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| How this comparator was evaluated The source table identifies borzoi-ensemble. Train the source’s random-forest classifier on the same balanced causality dataset and score the held-out chromosome test set. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-d277315f7d76 · Record review: needs review
3 source records and release history
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-comparator-ce0c8666036db12e
- areas
- dna-genomes
- entity level
- method
- configuration type
- pipeline
- version
- borzoi-ensemble: variant scores + random forest (paper Table 4)
- legacy kinds
- model
- entity classification
- review date: 2026-09-17; rationale: This record identifies a composed analysis workflow with separately identifiable upstream models, representations or tools and a downstream prediction/scoring procedure. Results belong to that complete composition rather than to an upstream model alone.; source ids: source-alphagenome-nature2026-tables; source-alphagenome-nature2026-supplementary-methods; evidence-official-56e5abfb5f12f1cd3b20; source locator: 'Suppl Table 4 Variant performan'!A14:P14; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.33, zero-shot and supervised eQTL causality; ambiguities: None recorded