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Protocol

GlycanML kingdom Accuracy: GlycanGT study: kingdom Accuracy

GlycanGT study: kingdom Accuracy. Scored with Accuracy on SugarBase taxonomy kingdom; GlycanML official motif split. Taxonomy: 13,209 glycans total across eight levels, 4–1,737 classes per level. Official fixed GlycanML motif-based train/validation/test splits (8:1:1). Section 2.5 reports class-balanced classifiers, train ∪ validation hyperparameter selection by randomized search with 3-fold cross-validation, followed by one evaluation on the held-out test set; complete procedure repeated with three random seeds, reporting mean and standard deviation. GlycanGT large model pretrained with 35% masking provides [Graph] embeddings to SVM/LightGBM; the selected classifier for each S4 row is not identified. Section 2.6 states that all four graph baselines were trained and evaluated on the same datasets/splits; it does not establish that each baseline used the GlycanGT downstream classifier search. SVM search: 10 iterations, RBF/linear, C logU(1e-3,1e2), gamma logU(1e-4,1e-1); LightGBM: 15 randomized iterations. Do not combine with separate original GlycanML-paper protocols.

5 evaluations · 5 metric rows

Overview

GlycanGT study: kingdom Accuracy. Scored with Accuracy on SugarBase taxonomy kingdom; GlycanML official motif split. Taxonomy: 13,209 glycans total across eight levels, 4–1,737 classes per level. Official fixed GlycanML motif-based train/validation/test splits (8:1:1). Section 2.5 reports class-balanced classifiers, train ∪ validation hyperparameter selection by randomized search with 3-fold cross-validation, followed by one evaluation on the held-out test set; complete procedure repeated with three random seeds, reporting mean and standard deviation. GlycanGT large model pretrained with 35% masking provides [Graph] embeddings to SVM/LightGBM; the selected classifier for each S4 row is not identified. Section 2.6 states that all four graph baselines were trained and evaluated on the same datasets/splits; it does not establish that each baseline used the GlycanGT downstream classifier search. SVM search: 10 iterations, RBF/linear, C logU(1e-3,1e2), gamma logU(1e-4,1e-1); LightGBM: 15 randomized iterations. Do not combine with separate original GlycanML-paper protocols.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Results

Each comparison retains its reviewed evaluation scope, dataset and metric. Results are shown without a pooled ranking.

GlycanML kingdom Accuracy: GlycanGT study: kingdom Accuracy

accuracy (fraction) · Higher values are better.

Every method GlycanML reports on GlycanGT study: kingdom Accuracy, scored with Accuracy on SugarBase taxonomy kingdom; GlycanML official motif split.

GlycanML kingdom Accuracy: GlycanGT study: kingdom Accuracy · SugarBase taxonomy kingdom; GlycanML official motif split (GlycanML split)

Evidence origin: Author-reported evaluation. Numerical source review does not establish independent reproduction.

GlycanGT published supplementary archive, Table S4; glycangt: Journal full-text XML · GlycanGT primary article Sections 2.1, 2.5, 2.6 and 3.1–3.2 (PMC13105845), Supplementary Table S4; columns A (task), C (metric), D (mean), E (SD)

Source-checked values from the GlycanGT authors, not independent reproduction. All 103 reported mean/SD pairs and all five methods retained.

All comparison limitations (9)
  • Source-checked values from the GlycanGT authors, not independent reproduction. All 103 reported mean/SD pairs and all five methods retained.
  • Accuracy remains on its original 0–1 scale. No cross-task or cross-metric aggregate is inferred.
  • Immunogenicity Macro-F1 is reported only for RGCN, SweetNet and GlycanGT; GlycanAA and Graphormer missing rows remain absent.
  • Source-reported zeros, including RGCN order accuracy and Macro-F1, are preserved as reported; they were not independently rerun.
  • GlycanGT per-task downstream classifier choice is not stated; SVM/LightGBM procedures are described collectively.
  • Article states a motif 8:1:1 split but does not give exact held-out counts/manifests in Table S4. Total dataset sizes are not test counts.
  • The published methods select masking ratio using downstream scores; the exact separation used for that selection is unreported here. Do not claim a fully independently untouched model-selection test set.
  • Separate study/protocol from the original GlycanML paper: shared benchmark family does not establish interchangeable scores.
  • The current outer archive hash differs from the previous September 16 snapshot. A new source ID pins the retrieved bytes; no prior source is overwritten.

Automated source review: 2026-09-23.

No unavailable values; missing scores remain labelled and are never plotted as zero.

Showing 5 of 5 matching rows.

Dots show point estimates. Whiskers show only explicitly defined uncertainty (standard deviation, standard error or a labelled interval); their definitions remain in Table. Unresolved uncertainty is not plotted. Differences do not establish statistical significance.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

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Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations
5

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Training-set class prior where supervised fitting is permitted

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Regularised classifier on simple permitted features, or protocol's conventional reference

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums

Coverage is derived from release 2026-09-23-2b89723c6dd9. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Evidence

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Evidence table

Inspect claims, sources and review details

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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

2 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-23-2b89723c6dd9
Property and statementOriginal source and locationReview and provenance
Relationship: part of
discovery-benchmark-glycanml
Individual claims
glycangt: Journal full-text XML

Original source ↗

GlycanGT primary article Sections 2.1, 2.5, 2.6 and 3.1–3.2 (PMC13105845), Supplementary Table S4; columns A (task), C (metric), D (mean), E (SD)

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Primary article XML snapshot
Retrieved: 2026-09-16T20:20:56.439056+00:00

source checked

automated source review · 2026-09-23

Audit details

Primary-source transcription with no human sign-off and no independent reproduction.

Field: links:part_of:discovery-benchmark-glycanml

Claim: glycangt-2026-table-s4-association-kingdom-accuracy

Source artifact SHA-256: 53e89a636c868c0329ee7eb6ae92f1028ec891940bc61730a148981b647fbbe5

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Relationship: part of
discovery-benchmark-glycanml
Individual claims
GlycanGT published supplementary archive, Table S4

Original source ↗

GlycanGT primary article Sections 2.1, 2.5, 2.6 and 3.1–3.2 (PMC13105845), Supplementary Table S4; columns A (task), C (metric), D (mean), E (SD)

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Published Bioinformatics btag147 supplementary archive, retrieved 2026-09-23; Table_S4.xlsx SHA-256 d7c35909bac6bcb78ca8fdb32c0463f05e692f15861a8184e65e415e7216f493
Retrieved: 2026-09-23T11:31:33.520570+00:00

source checked

automated source review · 2026-09-23

Audit details

Primary-source transcription with no human sign-off and no independent reproduction.

Field: links:part_of:discovery-benchmark-glycanml

Claim: glycangt-2026-table-s4-association-kingdom-accuracy

Source artifact SHA-256: 27748c6c0c0bb07b0105d274fb745fd4dfe702d34b9ee367d1ddacbc71c56ab0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-23-2b89723c6dd9 · Record review: source checked

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: glycangt-2026-table-s4-task-kingdom-accuracy

areas
glycans
tasks
GlycanGT study: kingdom Accuracy
metric
Accuracy
metric direction
higher
dataset
SugarBase taxonomy kingdom; GlycanML official motif split
protocol
Taxonomy: 13,209 glycans total across eight levels, 4–1,737 classes per level. Official fixed GlycanML motif-based train/validation/test splits (8:1:1). Section 2.5 reports class-balanced classifiers, train ∪ validation hyperparameter selection by randomized search with 3-fold cross-validation, followed by one evaluation on the held-out test set; complete procedure repeated with three random seeds, reporting mean and standard deviation. GlycanGT large model pretrained with 35% masking provides [Graph] embeddings to SVM/LightGBM; the selected classifier for each S4 row is not identified. Section 2.6 states that all four graph baselines were trained and evaluated on the same datasets/splits; it does not establish that each baseline used the GlycanGT downstream classifier search. SVM search: 10 iterations, RBF/linear, C logU(1e-3,1e2), gamma logU(1e-4,1e-1); LightGBM: 15 randomized iterations. Do not combine with separate original GlycanML-paper protocols.
source locator
GlycanGT primary article Sections 2.1, 2.5, 2.6 and 3.1–3.2 (PMC13105845), Supplementary Table S4; columns A (task), C (metric), D (mean), E (SD)
comparison panels
id: glycangt-2026-table-s4-panel-kingdom-accuracy; title: GlycanML kingdom Accuracy: GlycanGT study: kingdom Accuracy; protocol id: glycangt-2026-table-s4-task-kingdom-accuracy; dataset id: glycangt-2026-table-s4-dataset-sugarbase-taxonomy-kingdom-glycanml-official-motif-split; metric: accuracy; unit: fraction; direction: higher; result ids: glycangt-2026-table-s4-result-rgcn-kingdom-accuracy-accuracy; glycangt-2026-table-s4-result-glycanaa-kingdom-accuracy-accuracy; glycangt-2026-table-s4-result-sweetnet-kingdom-accuracy-accuracy; glycangt-2026-table-s4-result-glycangt-kingdom-accuracy-accuracy; glycangt-2026-table-s4-result-graphormer-kingdom-accuracy-accuracy; source ids: model-coverage-glycangt-table-s4-20260923-source; evidence-official-87c70bddba97a72a5e5d; source locator: GlycanGT primary article Sections 2.1, 2.5, 2.6 and 3.1–3.2 (PMC13105845), Supplementary Table S4; columns A (task), C (metric), D (mean), E (SD); context: Every method GlycanML reports on GlycanGT study: kingdom Accuracy, scored with Accuracy on SugarBase taxonomy kingdom; GlycanML official motif split.; caveats: Source-checked values from the GlycanGT authors, not independent reproduction. All 103 reported mean/SD pairs and all five methods retained.; Accuracy remains on its original 0–1 scale. No cross-task or cross-metric aggregate is inferred.; Immunogenicity Macro-F1 is reported only for RGCN, SweetNet and GlycanGT; GlycanAA and Graphormer missing rows remain absent.; Source-reported zeros, including RGCN order accuracy and Macro-F1, are preserved as reported; they were not independently rerun.; GlycanGT per-task downstream classifier choice is not stated; SVM/LightGBM procedures are described collectively.; Article states a motif 8:1:1 split but does not give exact held-out counts/manifests in Table S4. Total dataset sizes are not test counts.; The published methods select masking ratio using downstream scores; the exact separation used for that selection is unreported here. Do not claim a fully independently untouched model-selection test set.; Separate study/protocol from the original GlycanML paper: shared benchmark family does not establish interchangeable scores.; The current outer archive hash differs from the previous September 16 snapshot. A new source ID pins the retrieved bytes; no prior source is overwritten.; review: method: automated_source_review; date: 2026-09-23
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