result · source checked

0.78 auprc

ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking, auprc

Tested model: ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature
Task or benchmark: Supervised enhancer–gene linking (AlphaGenome paper)
Dataset: Supervised enhancer–gene linking: evaluated data subset
Procedure: Add the K562 RNA-seq input×gradient score to ENCODE-rE2G extended, rerun its full logistic-regression training pipeline and evaluate out-of-fold predictions.
Evaluation: ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking
Evidence: Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M18

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Evaluation results

Release 2026-09-17-a757f4af4277 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking Model: ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature · Benchmark: Supervised enhancer–gene linking (AlphaGenome paper) · Dataset: Supervised enhancer–gene linking: evaluated data subset Add the K562 RNA-seq input×gradient score to ENCODE-rE2G extended, rerun its full logistic-regression training pipeline and evaluate out-of-fold predictions. Author-reported evaluation · Evaluation metadata: needs review
0.78 auprc Unit: dimensionless · Direction: higher Aggregation: auPRC over labelled element–gene pairs, with separate distance-to-TSS strata in the paper.	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M18 Source checking is not independent reproduction.

Evidence table

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-a757f4af4277
Property and statement	Original source and location	Review and provenance
Reported result 0.78 Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!M18 Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked OOXML extraction and separate automated primary-source review · 2026-09-17 author reported Audit details Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: `attributes.printed_value` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact Extraction artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Extraction artifact

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Sources and history

Release 2026-09-17-a757f4af4277 · Record review: source checked

AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied

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Technical metadata and extraction receipts

Stable ID: alphagenome-2026-result-5ef7238b75eb48d7

areas: dna-genomes
printed value: 0.78
printed value basis: Workbook number format 0.00
numeric value: 0.78100000000000003
raw xml value: 0.78100000000000003
workbook number format: 0.00
metric: auprc
metric direction: higher
unit: dimensionless
aggregation: auPRC over labelled element–gene pairs, with separate distance-to-TSS strata in the paper.
uncertainty: Not reported
scored count: Not reported
eligible count: Not reported
source cells: 'Suppl Table 4 Variant performan'!M18
source locator: 'Suppl Table 4 Variant performan'!M18
review: method: OOXML extraction and separate automated primary-source review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.
missing metadata: uncertainty: unreported; scored count: unextracted; eligible count: unextracted; seeds: unreported
source warnings: None recorded

Related records

evaluation: ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking

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