Inverse-folding evaluation asks whether a method can propose amino-acid sequences compatible with a specified protein structure.
Explanatory profile: source reviewed · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Entity type | Task guide; concrete protocol identities remain separate.Sourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Datasets | No single dataset is fixed by this guide. Select a linked protocol and its versioned data release. · Not applicableSourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Organisms | No shared organism population is defined at this guide level. Record it for each selected dataset. · Not applicableSourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Assays | No single measurement assay is fixed by this guide; the endpoint and assay belong to the selected protocol. · Not applicableSourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Splits | No executable split is attached to this task identity. Use the selected protocol’s split manifest. · Not applicableSourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Allowed inputs | A target protein backbone and declared structural or sequence constraints for an inverse-folding protocol.Sourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Adaptation | No common fitting regime is imposed here. Keep pretrained, frozen, probed, fine-tuned and conventional methods distinct where applicable. · Not applicableSourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Metrics | Protocol-specific sequence recovery or structural assessment; experimental validation, when available, is a separate endpoint.Sourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
| Baselines | Use inverse-folding comparators supplied with the selected benchmark and match structural inputs and constraints.Sourcesdauparas/ProteinMPNN official source · ProteinMPNN README: overview, scoring outputs and training documentation |
Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.
Keep inverse folding separate from sequence-only generation and experimental function. ProteinMPNN takes structural context and produces sequence probabilities or candidate sequences. A concrete benchmark must state the held-out structures, permitted constraints and assessment. Recovery of a reference sequence and experimental success answer different questions.
This is a task guide, not a single versioned benchmark protocol. The connected resources provide examples or concrete procedures. A candidate method or proposed control is not evidence that an evaluation has been completed.
Release 2026-09-17-d277315f7d76 · 0 evaluations · 0 metric rows. Different protocols are not a single leaderboard.
No evaluations linked in this release.
Last literature check: 2026-09-17. Primary-source discovery and table/protocol screening; source checked is not independently reproduced. Raw acquisitions not automatically numerical publication approval.
| Paper or primary resource | Version | Reference |
|---|---|---|
| Robust deep learning based protein sequence design using ProteinMPNN | PMC primary-source artifact, version pinned by SHA256 | Read source DOI: 10.1126/science.add2187 |
broad task requires concrete protocol links
Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.
Stable record: catalog-task-protein-designTrace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
17 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Diagram caption Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | source checked automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Diagram steps ["Select held-out structural targets","Declare allowed conditioning","Generate or score candidate sequences","Evaluate the specified endpoint"] Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | source checked automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Diagram title Conceptual evaluation workflow Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | source checked automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Entity type Task guide; concrete protocol identities remain separate. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | source checked automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Datasets No single dataset is fixed by this guide. Select a linked protocol and its versioned data release. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | inapplicable automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Organisms No shared organism population is defined at this guide level. Record it for each selected dataset. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | inapplicable automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Assays No single measurement assay is fixed by this guide; the endpoint and assay belong to the selected protocol. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | inapplicable automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Splits No executable split is attached to this task identity. Use the selected protocol’s split manifest. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | inapplicable automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Allowed inputs A target protein backbone and declared structural or sequence constraints for an inverse-folding protocol. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | source checked automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Adaptation No common fitting regime is imposed here. Keep pretrained, frozen, probed, fine-tuned and conventional methods distinct where applicable. Individual claims | dauparas/ProteinMPNN official source ProteinMPNN README: overview, scoring outputs and training documentation Version: 8907e6671bfbfc92303b5f79c4b5e6ce47cdef57 | inapplicable automated source review · 2026-09-16 Audit detailsReviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-09-17-d277315f7d76 · Record review: discovered
Stable ID: catalog-task-protein-design