mRNABench VEP: Variant effect prediction
Variant effect prediction. Scored with AUPRC (%) on mRNABench VEP. A linear probe over frozen embeddings, scored as the mean over ten random seeds.
Overview
Variant effect prediction. Scored with AUPRC (%) on mRNABench VEP. A linear probe over frozen embeddings, scored as the mean over ten random seeds.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluation design
Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.
Benchmarks
These source-backed links do not make different protocols or scores interchangeable.
Recorded evaluations
Each evaluation records what was tested and under which conditions.
- 3UTRBERT on mRNABench VEP: Variant effect prediction
- AIDO.RNA on mRNABench VEP: Variant effect prediction
- DNABERT-S on mRNABench VEP: Variant effect prediction
- DNABERT2 on mRNABench VEP: Variant effect prediction
- ERNIE-RNA on mRNABench VEP: Variant effect prediction
- Evo1 on mRNABench VEP: Variant effect prediction
- Evo2 on mRNABench VEP: Variant effect prediction
- Helix-mRNA on mRNABench VEP: Variant effect prediction
- HyenaDNA on mRNABench VEP: Variant effect prediction
- Naive Baseline on mRNABench VEP: Variant effect prediction
- Naive Mamba on mRNABench VEP: Variant effect prediction
- NT on mRNABench VEP: Variant effect prediction
Run instructions
No runnable recipe has been reviewed for this task. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
A task describes a biological question. Choose a linked protocol to obtain concrete split and scoring instructions.
Published comparisons
Explore the results reported under one evaluation protocol. Each figure keeps its source, dataset and metric together; it is not a ranking across studies. The pooled view gathers every source table that reports the same metric and names what it does not hold constant.
mRNABench VEP: Variant effect prediction
auprc (percent) · Higher values are better for this metric.
Every method mRNABench reports on Variant effect prediction, scored with AUPRC (%) on mRNABench VEP.
- Naive Baseline · Method · Author-reported evaluation19.5
- Naive Mamba · Method · Author-reported evaluation10.2
- Supervised CNN · Method · Author-reported evaluation33.2
- 3UTRBERT · Configuration · Author-reported evaluation31.2
- AIDO.RNA · Configuration · Author-reported evaluation30.4
- DNABERT-S · Configuration · Author-reported evaluation30.6
- DNABERT2 · Configuration · Author-reported evaluation26.4
- ERNIE-RNA · Configuration · Author-reported evaluation28.9
- Evo1 · Configuration · Author-reported evaluation12.0
- Evo2 · Configuration · Author-reported evaluation32.1
- Helix-mRNA · Configuration · Author-reported evaluation7.6
- HyenaDNA · Configuration · Author-reported evaluation23.2
- NT · Configuration · Author-reported evaluation31.8
- Orthrus · Configuration · Author-reported evaluation27.0
- RNA-FM · Configuration · Author-reported evaluation25.7
- RNA-MSM · Configuration · Author-reported evaluation16.5
- RNABERT · Configuration · Author-reported evaluation19.2
- RNAErnie · Configuration · Author-reported evaluation17.3
- RiNALMo · Configuration · Author-reported evaluation31.6
- SpliceBERT · Configuration · Author-reported evaluation28.2
- UTR-LM · Configuration · Author-reported evaluation21.3
Source order is preserved. Plotted marks show point estimates; uncertainty, where reported, is retained in the printed values and table. Differences do not establish statistical significance.
mRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, column(VEP)Values, uncertainty and evidence
Scope and limitations
- Author-reported numbers, source checked but not independently reproduced.
- Metrics alternate between AUPRC on a percentage scale and Pearson R, so figures in different columns are on different scales.
- Each row is the best checkpoint of a model family, chosen by the authors, not the family's average.
Source transcription and grouping reviewed by automated source review on 2026-09-18. These experiments were not independently reproduced by rewire.
Tested entities and results
Release 2026-09-17-134cd1815de8 · 21 evaluations · 21 metric rows. Different protocols are not a single leaderboard. Where several source tables report the same metric, the published comparisons above offer a pooled view that names what it does not hold constant.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| 3UTRBERT on mRNABench VEP: Variant effect prediction Configuration: 3UTRBERTTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 31.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(3UTRBERT), column(VEP) Source checking is not independent reproduction. |
| AIDO.RNA on mRNABench VEP: Variant effect prediction Configuration: AIDO.RNATask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 30.4% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(AIDO.RNA), column(VEP) Source checking is not independent reproduction. |
| DNABERT-S on mRNABench VEP: Variant effect prediction Configuration: DNABERT-STask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 30.6% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(DNABERT-S), column(VEP) Source checking is not independent reproduction. |
| DNABERT2 on mRNABench VEP: Variant effect prediction Configuration: DNABERT2Task: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 26.4% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(DNABERT2), column(VEP) Source checking is not independent reproduction. |
| ERNIE-RNA on mRNABench VEP: Variant effect prediction Configuration: ERNIE-RNATask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 28.9% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(ERNIE-RNA), column(VEP) Source checking is not independent reproduction. |
| Evo1 on mRNABench VEP: Variant effect prediction Configuration: Evo1Task: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 12.0% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Evo1), column(VEP) Source checking is not independent reproduction. |
| Evo2 on mRNABench VEP: Variant effect prediction Configuration: Evo2Task: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 32.1% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Evo2), column(VEP) Source checking is not independent reproduction. |
| Helix-mRNA on mRNABench VEP: Variant effect prediction Configuration: Helix-mRNATask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 7.6% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Helix-mRNA), column(VEP) Source checking is not independent reproduction. |
| HyenaDNA on mRNABench VEP: Variant effect prediction Configuration: HyenaDNATask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 23.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(HyenaDNA), column(VEP) Source checking is not independent reproduction. |
| Naive Baseline on mRNABench VEP: Variant effect prediction Method: Naive BaselineTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 19.5% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Naive Baseline), column(VEP) Source checking is not independent reproduction. |
| Naive Mamba on mRNABench VEP: Variant effect prediction Method: Naive MambaTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 10.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Naive Mamba), column(VEP) Source checking is not independent reproduction. |
| NT on mRNABench VEP: Variant effect prediction Configuration: NTTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 31.8% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(NT), column(VEP) Source checking is not independent reproduction. |
| Orthrus on mRNABench VEP: Variant effect prediction Configuration: OrthrusTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 27.0% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Orthrus), column(VEP) Source checking is not independent reproduction. |
| RiNALMo on mRNABench VEP: Variant effect prediction Configuration: RiNALMoTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 31.6% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(RiNALMo), column(VEP) Source checking is not independent reproduction. |
| RNA-FM on mRNABench VEP: Variant effect prediction Configuration: RNA-FMTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 25.7% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(RNA-FM), column(VEP) Source checking is not independent reproduction. |
| RNA-MSM on mRNABench VEP: Variant effect prediction Configuration: RNA-MSMTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 16.5% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(RNA-MSM), column(VEP) Source checking is not independent reproduction. |
| RNABERT on mRNABench VEP: Variant effect prediction Configuration: RNABERTTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 19.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(RNABERT), column(VEP) Source checking is not independent reproduction. |
| RNAErnie on mRNABench VEP: Variant effect prediction Configuration: RNAErnieTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 17.3% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(RNAErnie), column(VEP) Source checking is not independent reproduction. |
| SpliceBERT on mRNABench VEP: Variant effect prediction Configuration: SpliceBERTTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 28.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(SpliceBERT), column(VEP) Source checking is not independent reproduction. |
| Supervised CNN on mRNABench VEP: Variant effect prediction Method: Supervised CNNTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 33.2% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(Supervised CNN), column(VEP) Source checking is not independent reproduction. |
| UTR-LM on mRNABench VEP: Variant effect prediction Configuration: UTR-LMTask: mRNABench VEP: Variant effect predictionDataset subset: mRNABench VEP (mRNABench split) A linear probe over frozen embeddings, scored as the mean over ten random seeds. Author-reported evaluation · Evaluation metadata: source checked | ||
| 21.3% auprc Unit: percent · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedmRNABench: A curated benchmark for mature mRNA property and function prediction · Table 2, row(UTR-LM), column(VEP) Source checking is not independent reproduction. |
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Relationship: part of discovery-benchmark-mrnabench Individual claims | mRNABench: A curated benchmark for mature mRNA property and function prediction Table 2, column(VEP) Version: preprint archived 2025-07-08 | source checked automated source review · 2026-09-18 Audit detailsPrimary-source transcription with no human sign-off and no independent reproduction. Field: Claim: mrnabench-association-vep Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. |
Sources and history
Release 2026-09-17-134cd1815de8 · Record review: source checked
1 source records and release history
- mRNABench: A curated benchmark for mature mRNA property and function prediction · Original source · preprint archived 2025-07-08
Technical metadata and extraction receipts
Stable ID: mrnabench-task-vep
- areas
- rna-transcriptomes
- tasks
- Variant effect prediction
- metric
- AUPRC (%)
- metric direction
- higher
- dataset
- mRNABench VEP
- protocol
- A linear probe over frozen embeddings, scored as the mean over ten random seeds.
- source locator
- Table 2, column(VEP)
- comparison panels
- id: mrnabench-panel-vep; title: mRNABench VEP: Variant effect prediction; protocol id: mrnabench-task-vep; dataset id: mrnabench-dataset-mrnabench-vep; metric: auprc; unit: percent; direction: higher; result ids: mrnabench-result-naive-baseline-vep-auprc; mrnabench-result-naive-mamba-vep-auprc; mrnabench-result-supervised-cnn-vep-auprc; mrnabench-result-3utrbert-vep-auprc; mrnabench-result-aido-rna-vep-auprc; mrnabench-result-dnabert-s-vep-auprc; mrnabench-result-dnabert2-vep-auprc; mrnabench-result-ernie-rna-vep-auprc; mrnabench-result-evo1-vep-auprc; mrnabench-result-evo2-vep-auprc; mrnabench-result-helix-mrna-vep-auprc; mrnabench-result-hyenadna-vep-auprc; mrnabench-result-nt-vep-auprc; mrnabench-result-orthrus-vep-auprc; mrnabench-result-rna-fm-vep-auprc; mrnabench-result-rna-msm-vep-auprc; mrnabench-result-rnabert-vep-auprc; mrnabench-result-rnaernie-vep-auprc; mrnabench-result-rinalmo-vep-auprc; mrnabench-result-splicebert-vep-auprc; mrnabench-result-utr-lm-vep-auprc; source ids: expansion-p3-mrnabench-2025; source locator: Table 2, column(VEP); context: Every method mRNABench reports on Variant effect prediction, scored with AUPRC (%) on mRNABench VEP.; caveats: Author-reported numbers, source checked but not independently reproduced.; Metrics alternate between AUPRC on a percentage scale and Pearson R, so figures in different columns are on different scales.; Each row is the best checkpoint of a model family, chosen by the authors, not the family's average.; review: method: automated_source_review; date: 2026-09-18
Related records
- part of: mRNABench
- subject: mRNABench VEP: part of discovery-benchmark-mrnabench
- benchmark: 3UTRBERT on mRNABench VEP: Variant effect prediction
- benchmark: AIDO.RNA on mRNABench VEP: Variant effect prediction
- benchmark: DNABERT-S on mRNABench VEP: Variant effect prediction
- benchmark: DNABERT2 on mRNABench VEP: Variant effect prediction
- benchmark: ERNIE-RNA on mRNABench VEP: Variant effect prediction
- benchmark: Evo1 on mRNABench VEP: Variant effect prediction
- benchmark: Evo2 on mRNABench VEP: Variant effect prediction
- benchmark: Helix-mRNA on mRNABench VEP: Variant effect prediction
- benchmark: HyenaDNA on mRNABench VEP: Variant effect prediction
- benchmark: Naive Baseline on mRNABench VEP: Variant effect prediction
- benchmark: Naive Mamba on mRNABench VEP: Variant effect prediction
- benchmark: NT on mRNABench VEP: Variant effect prediction
- benchmark: Orthrus on mRNABench VEP: Variant effect prediction
- benchmark: RiNALMo on mRNABench VEP: Variant effect prediction
- benchmark: RNA-FM on mRNABench VEP: Variant effect prediction
- benchmark: RNA-MSM on mRNABench VEP: Variant effect prediction
- benchmark: RNABERT on mRNABench VEP: Variant effect prediction
- benchmark: RNAErnie on mRNABench VEP: Variant effect prediction
- benchmark: SpliceBERT on mRNABench VEP: Variant effect prediction
- benchmark: Supervised CNN on mRNABench VEP: Variant effect prediction
- benchmark: UTR-LM on mRNABench VEP: Variant effect prediction