rewire.it
Task

non-coding RNA pairwise interaction prediction

Noncoding RNA-pair classification evaluates a strongly imbalanced interaction dataset with validation-tuned decision thresholds.

SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

1 evaluation · 1 metric row

At a glance

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
DatasetsRNA-KG-derived multispecies interaction pairs; sampled negatives preserve pair-type frequencies with a 20:1 negative-to-positive ratio.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
SplitsStratified 90:10 train/test partition; a further validation subset is drawn from training data.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
MetricsAccuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
BaselinesRandom classifier, IntaRNA and CUPID pooling/data-augmentation ablations.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
Leakage controlsThe threshold is selected by validation MCC; sequence-disjoint separation of interacting entities remains unextracted.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
UncertaintyThe cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim. · Not reported in inspected sources
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
Entity typePaper-specific computational evaluation protocol.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
OrganismsMultiple species represented in RNA-KG.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
AssaysRNA–RNA interaction annotations with sampled negative pairs.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
Allowed inputsPairs of noncoding RNA sequences.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
AdaptationSupervised pair classification using a stratified train/test partition and training-derived validation subset.
SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

How it works

How it worksComputational evaluation flow
Computational evaluation flow1. Input: Pairs of noncoding RNA sequences.. Then: 2. Evaluation: Supervised pair classification using a stratified train/test partition and training-derived validation subset.. Then: 3. Readout: Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type.Computational evaluation flow1. Input: Pairs of noncoding RNA sequences.. Then: 2. Evaluation: Supervised pair classification using a stratified train/test partition and training-derived validation subset.. Then: 3. Readout: Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type.Computational evaluation flow1. Input: Pairs of noncoding RNA sequences.. Then: 2. Evaluation: Supervised pair classification using a stratified train/test partition and training-derived validation subset.. Then: 3. Readout: Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type.

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
Evaluation methodology

RNA-KG-derived multispecies interaction pairs; sampled negatives preserve pair-type frequencies with a 20:1 negative-to-positive ratio. Stratified 90:10 train/test partition; a further validation subset is drawn from training data. Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type. Random classifier, IntaRNA and CUPID pooling/data-augmentation ablations. The threshold is selected by validation MCC; sequence-disjoint separation of interacting entities remains unextracted. The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.

SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Tested entities and results

Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
CUPID Data-aug-Avg: non-coding RNA pairwise interaction prediction

Data augmentation with average pooling for molecule-level ncRNA embeddings

Author-reported evaluation · Evaluation metadata: needs review

0.919 AUROC

Unit: fraction · Direction: unknown

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedComputational understanding of non-coding RNA pairwise interactions · Table 1, CUPID > Data-aug-Avg row, AUROC column

Source checking is not independent reproduction.

Papers and result coverage

Last literature check: 2026-09-17. Primary-paper discovery and source inspection. Source-checked results are not independently reproduced experiments.

Paper or primary resourceVersionReference
Computational understanding of non-coding RNA pairwise interactionsPMC archival version PMC12957212.1Read source
DOI: 10.3389/frai.2026.1749205

What is still missing

  • Interaction-pair splitting does not guarantee unseen RNA identities across partitions.
  • Random baseline AUPRC reflects class prevalence; do not treat it as a fitted model run.
  • CUPID variants are distinct adaptations; no uncertainty printed.
Search and extraction details

primary comparison table screened

Searches

  • "PMC12957212"

Evidence locations

  • Table 1
  • Methods: Data preparation and splitting; Data augmentation; Training hyper-parameters

Strengths and limitations

Strengths and considerations

  • A random classifier and explicit pooling/augmentation ablations isolate different sources of performance.
    SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Limitations and conditions

  • A pair-level split does not by itself establish transfer to unseen RNAs. AUPRC depends on the sampled class prevalence.
    SourcesComputational understanding of non-coding RNA pairwise interactions · Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages
Profile review details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Stable record: reported-task-c7ce06b753b8b6

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["Input: Pairs of noncoding RNA sequences.","Evaluation: Supervised pair classification using a stratified train/test partition and training-derived validation subset.","Readout: Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type."]

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Computational evaluation flow

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Datasets

RNA-KG-derived multispecies interaction pairs; sampled negatives preserve pair-type frequencies with a 20:1 negative-to-positive ratio.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Splits

Stratified 90:10 train/test partition; a further validation subset is drawn from training data.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Adaptation

Supervised pair classification using a stratified train/test partition and training-derived validation subset.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Metrics

Accuracy, balanced accuracy, precision, recall, F1, AUROC and AUPRC, both overall and by interacting pair type.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Baselines

Random classifier, IntaRNA and CUPID pooling/data-augmentation ablations.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Leakage controls

The threshold is selected by validation MCC; sequence-disjoint separation of interacting entities remains unextracted.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Uncertainty

The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.

Individual claims
Computational understanding of non-coding RNA pairwise interactions

Original source ↗

Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages

Version: PMC archival version PMC12957212.1
Retrieved: 2026-09-16T10:41:06Z

unreported

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.5.value

Source artifact SHA-256: 0e6719410b390ee9c4858bb9321042851100fb74df3aa109bf2af2b8aaff7ac1

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-task-c7ce06b753b8b6

areas
rna-transcriptomes
tasks
non-coding RNA pairwise interaction prediction
entity level
task
version
Not reported
task
non-coding RNA pairwise interaction prediction
scope note
Paper-specific evaluation task; protocol completeness requires further extraction.
benchmark research
review date: 2026-09-17; status: primary_comparison_table_screened; primary sources: expansion-p3-cupid-rna-interactions-2026; inspected locators: Table 1; Methods: Data preparation and splitting; Data augmentation; Training hyper-parameters; searched queries: "PMC12957212"; gaps: Interaction-pair splitting does not guarantee unseen RNA identities across partitions.; Random baseline AUPRC reflects class prevalence; do not treat it as a fitted model run.; CUPID variants are distinct adaptations; no uncertainty printed.; claim scope: Primary-paper discovery and source inspection. Source-checked results are not independently reproduced experiments.
historical missing metadata
protocol version: not_reported_in_legacy_extract; split: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This source-scoped record identifies the biological prediction task and holds its paper context. Preserve the existing task identity; exact split, model adaptation and scoring remain in linked evaluations or separate protocol records.; source ids: cupid-rna-interactions-2026; source locator: Methods: Dataset; Experimental evaluation: Data preparation and splitting; Evaluation metrics; cached text lines 15–17, 66–75; comparative evaluation and ablation passages; ambiguities: A paper- or suite-specific task may constrain some inputs or metrics; that alone does not make it interchangeable with a complete versioned protocol. No protocol equivalence is inferred.; Some legacy profile Entity type facts use the generic phrase computational evaluation protocol. That boilerplate is not sufficient to establish a single fixed protocol identity or to merge this task with another protocol record.
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