benchmark · task

TAPE Stability

Predict measured protein stability from sequence.

At a glance

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.

Data, procedure and scoring
Property	Description and evidence
Record type	Component tasksonglab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability
Inputs	Protein sequences and stability labelssonglab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability
Outputs and assessment	Spearman rank correlationsonglab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability
Datasets	Not extracted or verified for this record.
Organisms	Not extracted or verified for this record.
Assays	Not extracted or verified for this record.
Splits	Not extracted or verified for this record.
Adaptation	Not extracted or verified for this record.
Baselines	Not extracted or verified for this record.

How it works

Component evaluation overview

Conceptual component-task overview. Exact data versions, split files and scorer settings must be taken from the source.

Read the diagram as text

Protein sequences and stability labels
TAPE Stability
Spearman rank correlation

songlab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability

Procedure

This is the TAPE Stability component, not the parent suite as a whole. Choose secondary structure, contact prediction, remote homology, fluorescence or stability. Train a task head and evaluate using the corresponding data and metric. The current PyTorch repository differs from the original publication code.

songlab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability

Connected tasks and protocols

TAPE · suite · part of

These associations do not imply identical protocols or interchangeable scores.

Tested models and results

Release 2026-09-16-d74d282221a9 · 6 evaluations · 6 metric rows. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
TAPE Stability Bepler leaderboard evaluation Model: TAPE Bepler · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.64 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row Bepler; column Spearman's rho Source checking is not independent reproduction.
TAPE Stability LSTM leaderboard evaluation Model: TAPE LSTM · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.69 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row LSTM; column Spearman's rho Source checking is not independent reproduction.
TAPE Stability One Hot leaderboard evaluation Model: TAPE One Hot · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.19 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row One Hot; column Spearman's rho Source checking is not independent reproduction.
TAPE Stability ResNet leaderboard evaluation Model: TAPE ResNet · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.73 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row ResNet; column Spearman's rho Source checking is not independent reproduction.
TAPE Stability Transformer leaderboard evaluation Model: TAPE Transformer · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.73 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row Transformer; column Spearman's rho Source checking is not independent reproduction.
TAPE Stability Unirep leaderboard evaluation Model: TAPE Unirep · Benchmark: TAPE Stability · Dataset: TAPE Stability source dataset TAPE Stability Author-reported evaluation · Evaluation metadata: discovered
0.73 Spearman's rho Unit: correlation · Direction: higher	Uncertainty: unreported Scored: Not reported · Eligible: Not reported	source checkedsonglab-cal/tape official source · README.md > Leaderboard > Stability; row Unirep; column Spearman's rho Source checking is not independent reproduction.

Strengths and limitations

Strengths and considerations

Includes simple one-hot comparators alongside pretrained representations.songlab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability

Limitations and conditions

The maintainers explicitly advise using the original implementation to reproduce the original paper.songlab-cal/tape official source · README: List of Models and Tasks; Data; Leaderboard / Stability

Profile review details

Existing catalogue evidence and cited extraction inspected. The specific protocol gaps listed here remain unresolved; numerical source checks do not constitute complete methods review.

Stable record: discovery-benchmark-tape-stability

Sources and history

Release 2026-09-16-d74d282221a9 · Record review: discovered

songlab-cal/tape official source · Original source · 6d345c2b2bbf52cd32cf179325c222afd92aec7e

Download this release

Technical metadata and extraction receipts

Stable ID: discovery-benchmark-tape-stability

areas: protein-function
entity level: task
missing metadata: dataset release: unextracted; metric implementation: unextracted; split manifest: unextracted; version: unextracted
scope note: Specialist molecular or omics evaluation; protocol details require review before numerical comparison.
task: Stability
version: Not reported

Related records

parent: TAPE
part of: TAPE
benchmark: TAPE Stability Bepler leaderboard evaluation
benchmark: TAPE Stability LSTM leaderboard evaluation
benchmark: TAPE Stability One Hot leaderboard evaluation
benchmark: TAPE Stability ResNet leaderboard evaluation
benchmark: TAPE Stability Transformer leaderboard evaluation
benchmark: TAPE Stability Unirep leaderboard evaluation
subject: TAPE Stability: part of TAPE

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