This paper-specific evaluation tests protein variant-effect classification using variant-effects benchmark.
Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.
| Property | Description and evidence |
|---|---|
| Record type | Paper-specific task; protocol incompletely extractedStructure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC column |
| Inputs | variant-effects benchmarkStructure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC column |
| Assessment | AUROCStructure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC column |
| Recorded split or evaluation setting | paper evaluationStructure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC column |
| Datasets | Not extracted or verified for this record. |
| Organisms | Not extracted or verified for this record. |
| Assays | Not extracted or verified for this record. |
| Adaptation | Not extracted or verified for this record. |
| Baselines | Not extracted or verified for this record. |
Outline of the existing paper extraction. Split membership, fitting details and scorer implementation remain incompletely reviewed.
The existing paper extraction describes: combined amino-acid, secondary structure, solvent accessibility and contact-map scoring. This description is retained with the exact evaluation records; it is not a new protocol reconstruction.
Structure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC columnRelease 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| structure-informed pLM: protein variant-effect classification Model: structure-informed pLM · Benchmark: protein variant-effect classification · Dataset: variant-effects benchmark combined amino-acid, secondary structure, solvent accessibility and contact-map scoring Author-reported evaluation · Evaluation metadata: needs review | ||
| .803 AUROC Unit: fraction · Direction: unknown | Uncertainty: not reported in legacy extract Scored: Not reported · Eligible: Not reported | source checkedStructure-Informed Protein Language Models are Robust Predictors for Variant Effects · PMC12068927 HTML, Table4, AA+SS+RSA+CM row, AUROC column Source checking is not independent reproduction. |
Catalogue extraction inspected; protocol claims remain limited to the cited evidence. Missing details are not presumed absent from the original paper.
Stable record: reported-task-83be0998084c91Release 2026-09-16-d74d282221a9 · Record review: needs review
Stable ID: reported-task-83be0998084c91