Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
borzoi-ensemble (paper Table 4). A comparator reported by the AlphaGenome authors; protocol pages specify the dataset and adaptation.
Key specifications have not been extracted for this record. See the linked evaluation and sources for the reported setup.
limited source coverage · Automated source review, 2026-09-17. All specifications and missing details
Release 2026-09-17-d277315f7d76 · 14 evaluations · 14 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| borzoi-ensemble (paper Table 4): Zero-shot distance-balanced eQTL causality Configuration: borzoi-ensemble (paper Table 4)Protocol: Zero-shot distance-balanced eQTL causality (AlphaGenome paper)Dataset subset: Zero-shot distance-balanced eQTL causality: evaluated data subset Evaluate the gene-specific RNA variant score directly on the distance-balanced labels. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.702311127873157 tissue_weighted_mean_auroc Unit: dimensionless · Direction: higher Aggregation: auROC per tissue weighted by the tissue’s variant count; the table’s “gene_balanced” identifier must not override the methods’ explicit distance-balancing description. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L13 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Yoruba LCL dsQTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: Yoruba LCL dsQTL effect-size prediction (AlphaGenome paper)Dataset subset: Yoruba LCL dsQTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.792241 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L29 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): African-ancestry LCL caQTL classification Configuration: borzoi-ensemble (paper Table 4)Protocol: African-ancestry LCL caQTL classification (AlphaGenome paper)Dataset subset: African-ancestry LCL caQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.462369 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L19 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Polyadenylation-QTL causality Configuration: borzoi-ensemble (paper Table 4)Protocol: Polyadenylation-QTL causality (AlphaGenome paper)Dataset subset: Polyadenylation-QTL causality: evaluated data subset Summarize predicted RNA coverage near PASs, derive the largest allelic change in proximal-versus-distal usage, average tracks and classify positive versus matched negative variants. Unscored variants receive zero as specified by the paper. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.620662 PAS_10000_average_auprc Unit: dimensionless · Direction: higher Aggregation: Average auPRC over100 random positive-to-negative matching permutations; Table4 endpoint is PAS_10000. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L9 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Microglia caQTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: Microglia caQTL effect-size prediction (AlphaGenome paper)Dataset subset: Microglia caQTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.615864 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L31 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): European-ancestry LCL caQTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: European-ancestry LCL caQTL effect-size prediction (AlphaGenome paper)Dataset subset: European-ancestry LCL caQTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.510695 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L27 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): European-ancestry LCL caQTL classification Configuration: borzoi-ensemble (paper Table 4)Protocol: European-ancestry LCL caQTL classification (AlphaGenome paper)Dataset subset: European-ancestry LCL caQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.311657 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L21 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): African-ancestry LCL caQTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: African-ancestry LCL caQTL effect-size prediction (AlphaGenome paper)Dataset subset: African-ancestry LCL caQTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.648517 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L25 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Zero-shot enhancer–gene linking Configuration: borzoi-ensemble (paper Table 4)Protocol: Zero-shot enhancer–gene linking (AlphaGenome paper)Dataset subset: Zero-shot enhancer–gene linking: evaluated data subset Compute expression input-gradient contributions near each candidate element, normalize by gene-context background gradient magnitude and impute zero for elements outside model context. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.668 auprc Unit: dimensionless · Direction: higher Aggregation: auPRC over labelled element–gene pairs, with separate distance-to-TSS strata in the paper. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L17 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): SPI1 binding QTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: SPI1 binding QTL effect-size prediction (AlphaGenome paper)Dataset subset: SPI1 binding QTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.534904 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L37 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): SPI1 binding QTL classification Configuration: borzoi-ensemble (paper Table 4)Protocol: SPI1 binding QTL classification (AlphaGenome paper)Dataset subset: SPI1 binding QTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.467776 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L35 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Zero-shot CAGI5 MPRA activity-effect prediction (borzoi-ensemble-matched comparison) Configuration: borzoi-ensemble (paper Table 4)Protocol: Zero-shot CAGI5 MPRA activity-effect prediction (borzoi-ensemble-matched comparison) (AlphaGenome paper)Dataset subset: Zero-shot CAGI5 MPRA activity-effect prediction (borzoi-ensemble-matched comparison): evaluated data subset Compute locus/context Pearson correlations between predicted and observed effects. The Borzoi strategy uses its reported scoring windows and modified matching; the ChromBPNet comparison excludes the unavailable TERT-GBM context. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.55 mean_pearsonr_all Unit: correlation · Direction: higher Aggregation: Mean Pearson correlation over the included locus/context comparisons; Table4 rows10 and11 have different AlphaGenome scalars and must remain separate. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L11 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Yoruba LCL dsQTL classification Configuration: borzoi-ensemble (paper Table 4)Protocol: Yoruba LCL dsQTL classification (AlphaGenome paper)Dataset subset: Yoruba LCL dsQTL classification: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.60562 auPRC Unit: dimensionless · Direction: higher Aggregation: auPRC over causal/noncausal labels. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L23 Source checking is not independent reproduction. |
| borzoi-ensemble (paper Table 4): Coronary smooth-muscle caQTL effect-size prediction Configuration: borzoi-ensemble (paper Table 4)Protocol: Coronary smooth-muscle caQTL effect-size prediction (AlphaGenome paper)Dataset subset: Coronary smooth-muscle caQTL effect-size prediction: evaluated data subset Use the source’s local log-fold-change scorer, select the task-specific cell/assay tracks and compare against the source-provided QTL labels or measured effects. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.63039 pearsonr Unit: correlation · Direction: higher Aggregation: Pearson correlation against reported effect sizes of the causal/significant QTL set. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L33 Source checking is not independent reproduction. |
The source table identifies borzoi-ensemble. Summarize predicted RNA coverage near PASs, derive the largest allelic change in proximal-versus-distal usage, average tracks and classify positive versus matched negative variants. Unscored variants receive zero as specified by the paper.
No source-reviewed explanatory claims are recorded here yet.
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-comparator-8505839e4f17fac1Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Reported method | borzoi-ensembleSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants |
| Exact checkpoint | Not established by the summary table; inspect the protocol and original implementation. · Needs further source reviewSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants |
| Model type | Not extracted or verified for this record. |
| Inputs | Not extracted or verified for this record. |
| Outputs | Not extracted or verified for this record. |
| Parameters | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
15 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported method borzoi-ensemble Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Reported method borzoi-ensemble Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Reported method borzoi-ensemble Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| How this comparator was evaluated The source table identifies borzoi-ensemble. Summarize predicted RNA coverage near PASs, derive the largest allelic change in proximal-versus-distal usage, average tracks and classify positive versus matched negative variants. Unscored variants receive zero as specified by the paper. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A9:P9; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.36, Polyadenylation variants Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Release 2026-09-17-d277315f7d76 · Record review: needs review
Stable ID: alphagenome-2026-comparator-8505839e4f17fac1