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DNABERT2-Enhancer

DNABERT2-Enhancer combines a fine-tuned DNA transformer with a CNN to classify enhancers and their activity.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Abstract (paragraph 1); Results/Comparison of the proposed model with existing methods (paragraph 4)

1 evaluation · 1 metric row

How it worksEvaluated procedure (conceptual)
Evaluated procedure (conceptual)1. DNA sequence windows. Then: 2. DNABERT2-Enhancer. Then: 3. Enhancer/non-enhancer labels and strong/weak enhancer classificationEvaluated procedure (conceptual)1. DNA sequence windows. Then: 2. DNABERT2-Enhancer. Then: 3. Enhancer/non-enhancer labels and strong/weak enhancer classificationEvaluated procedure (conceptual)1. DNA sequence windows. Then: 2. DNABERT2-Enhancer. Then: 3. Enhancer/non-enhancer labels and strong/weak enhancer classification

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)

At a glance

Model type

DNA sequence transformer; this record is the paper-specific evaluated configuration.

SourcesMAGICS-LAB/DNABERT_2 README.md · README.md model description

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
DNABERT2-Enhancer: enhancer recognition

first-layer enhancer versus non-enhancer classifier

Author-reported evaluation · Evaluation metadata: needs review

0.965 AUC

Unit: fraction · Direction: unknown

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Table 4, first-layer DNABERT2-Enhancer row, AUC column

Source checking is not independent reproduction.

How it works

How the evaluated method works

DNABERT-2 initialises a BERT feature extractor. Transfer learning adapts it to enhancer data, and a convolutional network classifies the resulting sequence features.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)
Underlying method and version boundaries

DNABERT-2 replaces overlapping k-mer tokens with byte-pair encoding and uses ALiBi positional biases. The official 117M model produces 768-dimensional token representations; downstream classifiers and pooling choices are separate configuration details.

SourcesMAGICS-LAB/DNABERT_2 README.md · README.md; introduction, model description, pretrained-model and usage sections at pinned revision
What was evaluated

The linked evaluation record identifies DNABERT2-Enhancer: enhancer recognition. Its dataset, split, adaptation and evidence origin remain attached to the reported results.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · The named evaluation’s methods and comparison table; exact preserved evaluation IDs: evaluation-b2-dnabert2-enhancer-2025

Strengths and limitations

Profile review details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Stable record: reported-model-d0e594ec3c0430

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
PropertyDescription and evidence
Model typeDNA sequence transformer; this record is the paper-specific evaluated configuration.
SourcesMAGICS-LAB/DNABERT_2 README.md · README.md model description
Architecture / procedureDNABERT-2 initialises a BERT feature extractor. Transfer learning adapts it to enhancer data, and a convolutional network classifies the resulting sequence features.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)
Biological inputsDNA sequence windows
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Conclusion (paragraph 1); Discussion (paragraph 3)
OutputsEnhancer/non-enhancer labels and strong/weak enhancer classification
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Introduction (paragraph 7); Materials and methods/Benchmark dataset (paragraph 4)
ParametersAn aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. · Not reported in inspected sources
Sources (2)Utilizing a deep learning model based on BERT for identifying enhancers and their strength; MAGICS-LAB/DNABERT_2 README.md · Materials and methods/Benchmark dataset; Materials and methods/DNABERT2-enhancer model; Materials and methods/DNABERT-2 model; Materials and methods/CNN model; Results/Comparison of the proposed model with existing methods; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision
Known versions / configurationDNABERT2-Enhancer is the comparison-table label; that label does not specify an immutable weight revision. · Not reported in inspected sources
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Model identification in the comparison table and corresponding Methods; immutable checkpoint revision is not supplied by the table label.
Training data / fittingLiu and Basith enhancer datasets; Basith includes eight cell-line subsets, 204–2,000-bp sequences and a 60% CD-HIT redundancy threshold.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Materials and methods/Benchmark dataset (paragraph 3); Materials and methods/Benchmark dataset (paragraph 1)
Context limitsThe Basith benchmark includes 204–2,000-bp sequences; this is benchmark input coverage, not a validated universal model limit.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Results (paragraph 3); Materials and methods/DNABERT2-enhancer model (paragraph 1)
AccessOfficial upstream implementation and usage documentation: https://github.com/MAGICS-LAB/DNABERT_2/blob/f25bed9ee20db966dff39e5c1571249d04e36404/README.md. This pinned documentation revision is not automatically the evaluated weight revision.
SourcesMAGICS-LAB/DNABERT_2 README.md · README.md; installation, model download and usage instructions
Code licenceApache 2.0 (upstream repository code at the cited revision; this does not establish every dependency or historical checkpoint licence).
SourcesMAGICS-LAB/DNABERT_2 LICENSE · LICENSE; complete licence text
Weights licenceThe inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately. · Not reported in inspected sources
SourcesMAGICS-LAB/DNABERT_2 README.md · README.md; checkpoint/access documentation and licence scope

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

21 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["DNA sequence windows","DNABERT2-Enhancer","Enhancer/non-enhancer labels and strong/weak enhancer classification"]

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Evaluated procedure (conceptual)

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.title

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Model type

DNA sequence transformer; this record is the paper-specific evaluated configuration.

Individual claims
MAGICS-LAB/DNABERT_2 README.md

Original source ↗

README.md model description

Version: f25bed9ee20db966dff39e5c1571249d04e36404
Retrieved: 2026-09-16T20:00:02.624261+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 734a8cec5f667d74d421bf3b273ad7e256216109636da45aa7ceba21cd34de16

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Architecture / procedure

DNABERT-2 initialises a BERT feature extractor. Transfer learning adapts it to enhancer data, and a convolutional network classifies the resulting sequence features.

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Weights licence

The inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately.

Individual claims
MAGICS-LAB/DNABERT_2 README.md

Original source ↗

README.md; checkpoint/access documentation and licence scope

Version: f25bed9ee20db966dff39e5c1571249d04e36404
Retrieved: 2026-09-16T20:00:02.624261+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 734a8cec5f667d74d421bf3b273ad7e256216109636da45aa7ceba21cd34de16

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Biological inputs

DNA sequence windows

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Conclusion (paragraph 1); Discussion (paragraph 3)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Outputs

Enhancer/non-enhancer labels and strong/weak enhancer classification

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Introduction (paragraph 7); Materials and methods/Benchmark dataset (paragraph 4)

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Materials and methods/Benchmark dataset; Materials and methods/DNABERT2-enhancer model; Materials and methods/DNABERT-2 model; Materials and methods/CNN model; Results/Comparison of the proposed model with existing methods; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
MAGICS-LAB/DNABERT_2 README.md

Original source ↗

Materials and methods/Benchmark dataset; Materials and methods/DNABERT2-enhancer model; Materials and methods/DNABERT-2 model; Materials and methods/CNN model; Results/Comparison of the proposed model with existing methods; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: f25bed9ee20db966dff39e5c1571249d04e36404
Retrieved: 2026-09-16T20:00:02.624261+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 734a8cec5f667d74d421bf3b273ad7e256216109636da45aa7ceba21cd34de16

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

3 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-model-d0e594ec3c0430

areas
dna-genomes
entity level
method
version
not stated in table
reported name
DNABERT2-Enhancer
historical missing metadata
checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
model
entity classification
review date: 2026-09-17; rationale: This source-scoped entry preserves the method/configuration actually named in an evaluation. It is neither a global family identity nor proof of an immutable checkpoint; the linked evaluation retains adaptation, fitting and scoring details.; source ids: dnabert2-enhancer-2025; evidence-reported-base-dnabert2-readme-md; source locator: Materials and methods/DNABERT2-enhancer model (paragraph 1); Materials and methods/DNABERT-2 model (paragraph 4) | README.md model description | Abstract (paragraph 1); Results/Comparison of the proposed model with existing methods (paragraph 4); ambiguities: Configuration means the source-labelled evaluated identity. It does not establish missing checkpoint hashes, default settings or equivalence to same-named records in other papers.
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