Splicing-QTL causality: evaluated data subset
Borzoi-curated eQTL-catalogue sQTL data across GTEx tissues, with distance-matched non-sQTL controls.
Subset and evaluation context
This record describes a particular subset or cohort used in an evaluation. Its results do not describe the full dataset.
Evaluation results
Release 2026-09-17-d277315f7d76 · 2 evaluations · 2 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| AlphaGenome distilled all-fold student: Splicing-QTL causality Configuration: AlphaGenome distilled all-fold studentProtocol: Splicing-QTL causality (AlphaGenome paper)Dataset subset: Splicing-QTL causality: evaluated data subset Compare predicted splicing effects for causal sQTLs and matched negatives; keep the wide and proximal splice-distance analyses distinct. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.76 tissue_weighted_mean_auprc Unit: dimensionless · Direction: higher Aggregation: auPRC per tissue, averaged with variant-count weights. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M5 Source checking is not independent reproduction. |
| Pangolin (paper Table 4): Splicing-QTL causality Configuration: Pangolin (paper Table 4)Protocol: Splicing-QTL causality (AlphaGenome paper)Dataset subset: Splicing-QTL causality: evaluated data subset Compare predicted splicing effects for causal sQTLs and matched negatives; keep the wide and proximal splice-distance analyses distinct. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.731911 tissue_weighted_mean_auprc Unit: dimensionless · Direction: higher Aggregation: auPRC per tissue, averaged with variant-count weights. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L5 Source checking is not independent reproduction. |
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
24 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.entity_level evaluation_subset Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.entity_level evaluation_subset Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.entity_level evaluation_subset Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.exact_manifest No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.exact_manifest No value recorded Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | missing or unspecified No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.exact_manifest No value recorded Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | missing or unspecified No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.reported_dataset_counts [{"positive":21514,"negative":21514,"count_unit":"variant/tissue pairs","scope":"full curated dataset before final chromosome test split","source_locator":"Supplementary Methods p.30, sQTLs"}] Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.reported_dataset_counts [{"positive":21514,"negative":21514,"count_unit":"variant/tissue pairs","scope":"full curated dataset before final chromosome test split","source_locator":"Supplementary Methods p.30, sQTLs"}] Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.reported_dataset_counts [{"positive":21514,"negative":21514,"count_unit":"variant/tissue pairs","scope":"full curated dataset before final chromosome test split","source_locator":"Supplementary Methods p.30, sQTLs"}] Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.source_dataset_label GTEx / Borzoi paper Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-d277315f7d76 · Record review: needs review
3 source records and release history
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-t4-dataset-4
- areas
- dna-genomes
- entity level
- evaluation_subset
- source dataset label
- GTEx / Borzoi paper
- source subset scope
- Zero-shot scorer development uses validation chromosomes 1,2,4,5,7,8,10,11,13,14,15,17,20,22,X; final test chromosomes are 3,6,9,12,16,18,19,21. This partitions variant evaluation labels; the distilled model’s teachers were trained on all reference-genome folds.
- exact manifest
- Not reported
- reported dataset counts
- positive: 21514; negative: 21514; count unit: variant/tissue pairs; scope: full curated dataset before final chromosome test split; source locator: Supplementary Methods p.30, sQTLs
- missing metadata
- split manifest: unextracted; per score denominator: unextracted
- legacy kinds
- dataset
- entity classification
- review date: 2026-09-17; rationale: The record explicitly identifies the source-filtered and split-specific evaluated data population. Preserve it as a dataset subset, including comparator-specific selection, without inferring an unrecorded parent accession or equating differently filtered populations.; source ids: source-alphagenome-nature2026-tables; source-alphagenome-nature2026-supplementary-methods; evidence-official-56e5abfb5f12f1cd3b20; source locator: 'Suppl Table 4 Variant performan'!A5:P5; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.30, sQTLs; methods: p.30, Splicing Quantitative Trait Loci; paper: Fig.3f; methods: p.30, Chromosome Splits for Variant Benchmarks; paper: Fig.1e; tables: Suppl Table 4 Variant performan; evaluation index 4; sheet rows 5; ambiguities: None recorded