AlphaGenome ensemble of four fold-1 models: Human splice-site classification: RNA-derived
Compare probabilities with the selected binary splice-site labels at genomic positions.
Evaluation procedure
Compare probabilities with the selected binary splice-site labels at genomic positions.
- Model
- AlphaGenome ensemble of four fold-1 models
- Benchmark
- Human splice-site classification: RNA-derived (AlphaGenome paper)
- Dataset
- Human splice-site classification: RNA-derived: evaluated data subset
- origin
- Author-reported evaluation
- configuration
- AlphaGenome ensemble of four fold-1 models
- protocol id
- alphagenome-2026-t3-protocol-1
- dataset version
- Not reported
- split
- Fold-1 ensemble evaluated on held-out intervals from chromosomes 1,3,5,7,9 to overlap the peer models’ test data.
- population
- RNA-seq-observed splice sites from filtered STAR junctions; the two label sources are separate evaluations.
- inputs
- Not reported
- adaptation
- AlphaGenome ensemble of four fold-1 models
- metric implementation
- Not reported
- aggregation
- Compute auPRC separately for four strand/site classes and average the four values.
- budget
- Not reported
Metadata review: needs review. Unreported conditions prevent automatic comparisons.
Evaluation results
Release 2026-09-17-a757f4af4277 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| AlphaGenome ensemble of four fold-1 models: Human splice-site classification: RNA-derived Model: AlphaGenome ensemble of four fold-1 models · Benchmark: Human splice-site classification: RNA-derived (AlphaGenome paper) · Dataset: Human splice-site classification: RNA-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.79 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K2; 'Suppl Table 3 Track performance'!K3 Source checking is not independent reproduction. |
Evidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
63 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.comparison.adaptation AlphaGenome ensemble of four fold-1 models Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.adaptation AlphaGenome ensemble of four fold-1 models Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.adaptation AlphaGenome ensemble of four fold-1 models Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.aggregation Compute auPRC separately for four strand/site classes and average the four values. Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.aggregation Compute auPRC separately for four strand/site classes and average the four values. Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.aggregation Compute auPRC separately for four strand/site classes and average the four values. Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.budget No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary methods No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| attributes.comparison.budget No value recorded Context-only references | AlphaGenome Nature 2026 supplementary comparison tables No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| attributes.comparison.dataset_version No value recorded Context-only references | alphagenome: Journal full-text XML No field-specific location recorded Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-evaluation-8010c5f524180a8f
- areas
- dna-genomes
- origin
- author_reported
- protocol
- Compare probabilities with the selected binary splice-site labels at genomic positions.
- version
- AlphaGenome ensemble of four fold-1 models
- source evaluation index
- 1
- source table
- 3
- comparison
- protocol id: alphagenome-2026-t3-protocol-1; dataset version: Not reported; split: Fold-1 ensemble evaluated on held-out intervals from chromosomes 1,3,5,7,9 to overlap the peer models’ test data.; population: RNA-seq-observed splice sites from filtered STAR junctions; the two label sources are separate evaluations.; inputs: Not reported; adaptation: AlphaGenome ensemble of four fold-1 models; metric implementation: Not reported; aggregation: Compute auPRC separately for four strand/site classes and average the four values.; budget: Not reported
- context
- allowed inputs: Reference DNA sequence and predicted donor+/acceptor+/donor−/acceptor− probabilities; SpliceAI and DeltaSplice are comparison models.; limitations: RNA-derived labels represent observed sites; GTF labels represent annotation. These are not interchangeable populations. Pangolin is excluded because its outputs do not separate donors from acceptors.
- missing metadata
- dataset version: unextracted; exact input manifest: unextracted; inference budget: unreported; scoring failures: unreported
Related records
- model: AlphaGenome ensemble of four fold-1 models
- benchmark: Human splice-site classification: RNA-derived (AlphaGenome paper)
- dataset: Human splice-site classification: RNA-derived: evaluated data subset
- evaluation: AlphaGenome ensemble of four fold-1 models: Human splice-site classification: RNA-derived, auPRC