Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
model · method
AlphaGenome fold-0 track model on comparator-matched test peaks
AlphaGenome fold-0 track model on comparator-matched test peaks. This is the configuration evaluated in the Nature paper, not an identification of the current hosted API revision.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g captionRelated family profile: AlphaGenome. This page retains the exact record and its evaluation context.
At a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Evaluated system | AlphaGenome fold-0 track model on comparator-matched test peaksAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption |
| Checkpoint artifact | Not established for these paper scores; no released checkpoint is inferred. · Needs further source reviewAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption |
| Evaluation scope | Paper-evaluated AlphaGenome configurationAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption |
| Model type | Not extracted or verified for this record. |
| Inputs | Not extracted or verified for this record. |
| Outputs | Not extracted or verified for this record. |
| Parameters | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
How it works
Evaluated configuration
AlphaGenome fold-0 track model evaluated on peer-model test peaks after excluding overlap with AlphaGenome fold-0 training intervals. Evaluate signal correlation, log-total-count correlation and profile JSD as separate metrics; retain only endpoints actually listed for this evaluation in Table3.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g captionBenchmarks and results
Release 2026-09-17-a757f4af4277 · 3 evaluations · 8 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| AlphaGenome fold-0 track model on comparator-matched test peaks: PRO-cap prediction on held-out peaks Model: AlphaGenome fold-0 track model on comparator-matched test peaks · Benchmark: PRO-cap prediction on held-out peaks (AlphaGenome paper) · Dataset: PRO-cap prediction on held-out peaks: evaluated data subset Evaluate signal correlation, log-total-count correlation and profile JSD as separate metrics; retain only endpoints actually listed for this evaluation in Table3. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.79 pearsonr log total count Unit: correlation · Direction: higher Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K16 Source checking is not independent reproduction. |
| 0.53 jsd Unit: dimensionless · Direction: lower Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K17 Source checking is not independent reproduction. |
| AlphaGenome fold-0 track model on comparator-matched test peaks: DNase prediction on held-out peaks Model: AlphaGenome fold-0 track model on comparator-matched test peaks · Benchmark: DNase prediction on held-out peaks (AlphaGenome paper) · Dataset: DNase prediction on held-out peaks: evaluated data subset Evaluate signal correlation, log-total-count correlation and profile JSD as separate metrics; retain only endpoints actually listed for this evaluation in Table3. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.79 log1p_count_pearsonr Unit: correlation · Direction: higher Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K23 Source checking is not independent reproduction. |
| 0.75 pearsonr Unit: correlation · Direction: higher Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K22 Source checking is not independent reproduction. |
| 0.51 profile_jsd Unit: dimensionless · Direction: lower Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K24 Source checking is not independent reproduction. |
| AlphaGenome fold-0 track model on comparator-matched test peaks: ATAC prediction on held-out peaks Model: AlphaGenome fold-0 track model on comparator-matched test peaks · Benchmark: ATAC prediction on held-out peaks (AlphaGenome paper) · Dataset: ATAC prediction on held-out peaks: evaluated data subset Evaluate signal correlation, log-total-count correlation and profile JSD as separate metrics; retain only endpoints actually listed for this evaluation in Table3. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.86 pearsonr Unit: correlation · Direction: higher Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K28 Source checking is not independent reproduction. |
| 0.85 log1p_count_pearsonr Unit: correlation · Direction: higher Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K29 Source checking is not independent reproduction. |
| 0.46 profile jsd Unit: dimensionless · Direction: lower Aggregation: Table3 reports task summary scalars; Extended Data Fig.3 shows per-cell-line comparisons. The inspected caption does not fully specify pooling across peaks/cell lines. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K30 Source checking is not independent reproduction. |
Strengths and limitations
Limitations and conditions
- The publication result does not establish equivalence to another checkpoint or hosted service.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption
Profile review details
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-model-921623a22036eda5Evidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
21 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Evaluated system AlphaGenome fold-0 track model on comparator-matched test peaks Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Evaluated system AlphaGenome fold-0 track model on comparator-matched test peaks Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Evaluated system AlphaGenome fold-0 track model on comparator-matched test peaks Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Checkpoint artifact Not established for these paper scores; no released checkpoint is inferred. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Checkpoint artifact Not established for these paper scores; no released checkpoint is inferred. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Checkpoint artifact Not established for these paper scores; no released checkpoint is inferred. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Evaluation scope Paper-evaluated AlphaGenome configuration Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Evaluation scope Paper-evaluated AlphaGenome configuration Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Evaluation scope Paper-evaluated AlphaGenome configuration Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Limitation The publication result does not establish equivalence to another checkpoint or hosted service. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A16:N16; Supplementary Methods p.21, continuous-track evaluation; Table8 ProCapNet port; Main paper Extended Data Fig.3f,g caption Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-model-921623a22036eda5
- areas
- dna-genomes
- entity level
- method
- configuration type
- paper_evaluation
- version
- AlphaGenome fold-0 track model on comparator-matched test peaks
Related records
- family: AlphaGenome
- model: AlphaGenome fold-0 track model on comparator-matched test peaks: ATAC prediction on held-out peaks
- model: AlphaGenome fold-0 track model on comparator-matched test peaks: DNase prediction on held-out peaks
- model: AlphaGenome fold-0 track model on comparator-matched test peaks: PRO-cap prediction on held-out peaks
- subject: AlphaGenome fold-0 track model on comparator-matched test peaks: family