model · method

ESM-2

ESM-2 is the method recorded for Zero-shot variant effect prediction. This page preserves the configuration reported by Endowing protein language models with structural knowledge.

1 evaluations · 1 metric rows

At a glance

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.

Inputs, outputs and configuration
Property	Description and evidence
Recorded dataset	ProteinShake VEP datasetsEndowing protein language models with structural knowledge · Table 2, ESM-2 row, Zero-shot VEP Mean \|ρ\| column
Model type	Not extracted or verified for this record.
Known versions	Not extracted or verified for this record.
Training data	Not extracted or verified for this record.
Context limits	Not extracted or verified for this record.
Access	Not extracted or verified for this record.
Code licence	Not extracted or verified for this record.
Weights licence	Not extracted or verified for this record.

How it works

Recorded evaluation

The imported evaluation describes this procedure: Zero-shot VEP; paper averages absolute Spearman correlations.

Endowing protein language models with structural knowledge · Table 2, ESM-2 row, Zero-shot VEP Mean |ρ| column

Benchmarks and results

Release 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
ESM-2: Zero-shot variant effect prediction Model: ESM-2 · Benchmark: Zero-shot variant effect prediction · Dataset: ProteinShake VEP datasets Zero-shot VEP; paper averages absolute Spearman correlations. Independent external evaluation · Evaluation metadata: needs review
0.489 Mean \|Spearman rho\| Unit: unitless · Direction: unknown	Uncertainty: not reported in legacy extract Scored: Not reported · Eligible: Not reported	source checkedEndowing protein language models with structural knowledge · Table 2, ESM-2 row, Zero-shot VEP Mean \|ρ\| column Source checking is not independent reproduction.

Strengths and limitations

Strengths and considerations

No source-reviewed explanatory claims are recorded here yet.

Limitations and conditions

This is an evidence-limited profile. The recorded evaluation context does not establish performance on other datasets or configurations.Endowing protein language models with structural knowledge · Table 2, ESM-2 row, Zero-shot VEP Mean |ρ| column

Profile review details

Reviewed the existing release record, its source pointer and linked evaluation context. This is not a fresh full-text architecture review or independent reproduction; numerical review status is unchanged.

Stable record: reported-model-d25dab1a9c4fff

Sources and history

Release 2026-09-16-d74d282221a9 · Record review: needs review

Endowing protein language models with structural knowledge · Original source · PMC12603367.1

Download this release

Technical metadata and extraction receipts

Stable ID: reported-model-d25dab1a9c4fff

areas: proteins-complexes
entity level: method
version: Not reported
reported name: ESM-2
missing metadata: version: not_reported_in_legacy_extract; checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract

Related records

model: ESM-2: Zero-shot variant effect prediction

Suggest a correction