Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
HMPD-disease genomic embedding evaluation. Scored with accuracy on HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3. Frozen model last-hidden-state embeddings, mean pooled. Logistic regression for eight classification tasks and mini-batch k-means for eight clustering tasks. Source paper Section 5.3. Current official gene-mteb implementation corroborates task identities but its commit is not proven identical to the paper evaluator. Exact dataset release, split hash, scored counts and evaluator commit are unreported in the paper. Do not substitute current mutable HF main for the original split.
Overview
HMPD-disease genomic embedding evaluation. Scored with accuracy on HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3. Frozen model last-hidden-state embeddings, mean pooled. Logistic regression for eight classification tasks and mini-batch k-means for eight clustering tasks. Source paper Section 5.3. Current official gene-mteb implementation corroborates task identities but its commit is not proven identical to the paper evaluator. Exact dataset release, split hash, scored counts and evaluator commit are unreported in the paper. Do not substitute current mutable HF main for the original split.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Results
Each comparison retains its reviewed evaluation scope, dataset and metric. Results are shown without a pooled ranking.
Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
accuracy (fraction) · Higher values are better.
Every method Gene-MTEB genomic embedding benchmark reports on HMPD-disease genomic embedding evaluation, scored with accuracy on HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3.
Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation · HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3 (Gene-MTEB genomic embedding benchmark split)
Evidence origin: Author-reported evaluation. Numerical source review does not establish independent reproduction.
METAGENE-1 v1: Gene-MTEB complete component tasks · Table 3 (S5.T3), row HMPD-disease, column DNABERT-2; Section 5.3 paragraphs S5.SS3.p2.1 and S5.SS3.p3.1All 16 component tasks and five methods are included. Twenty-five printed aggregate cells are retained in a companion receipt, excluded from task-level result counts to avoid counting derived averages as extra experiments.
All comparison limitations (5)
- All 16 component tasks and five methods are included. Twenty-five printed aggregate cells are retained in a companion receipt, excluded from task-level result counts to avoid counting derived averages as extra experiments.
- Classification accuracy and clustering V-measure must not be combined into a universal performance metric.
- Paper source does not pin exact evaluator/data revisions or per-task denominators. Current code metadata uses mutable dataset revision main; its development metadata is not asserted to be the evaluated paper version.
- Paper calls embeddings zero-shot; this does not mean classification is label-free: logistic-regression probes use training labels.
- No uncertainty intervals or repeats are printed.
Automated source review: 2026-09-23.
No unavailable values; missing scores remain labelled and are never plotted as zero.
Showing 5 of 5 matching rows.
Dots show point estimates. Whiskers show only explicitly defined uncertainty (standard deviation, standard error or a labelled interval); their definitions remain in Table. Unresolved uncertainty is not plotted. Differences do not establish statistical significance.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Evaluation design
Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.
Benchmarks
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Recorded evaluations
Each evaluation records what was tested and under which conditions.
- DNABERT-2 on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- DNABERT-S on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- METAGENE-1 on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- NT-2.5b-1000g on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- NT-2.5b-Multi on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.
- Author-reported evaluations
- 5
Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.
Null control
Proposed control: requires review
Unintegrated representation using protocol preprocessing
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Conventional reference
Proposed control: requires review
Protocol-specific conventional integration method
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums
Coverage is derived from release 2026-09-23-2b89723c6dd9. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Relationship: part of discovery-benchmark-gene-mteb Individual claims | METAGENE-1 v1: Gene-MTEB complete component tasks Table 3 (S5.T3), row HMPD-disease, column DNABERT-2; Section 5.3 paragraphs S5.SS3.p2.1 and S5.SS3.p3.1 Version: arXiv:2501.02045v1 | source checked automated source review · 2026-09-23 Audit detailsPrimary-source transcription with no human sign-off and no independent reproduction. Field: Claim: metagene-gene-mteb-association-hmpd-disease Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
View linked audit checks and correction history
Release 2026-09-23-2b89723c6dd9 · Record review: source checked
1 source records and release history
- METAGENE-1 v1: Gene-MTEB complete component tasks · Original source · arXiv:2501.02045v1
Technical metadata and extraction receipts
Stable ID: metagene-gene-mteb-task-hmpd-disease
- areas
- dna-genomes
- tasks
- HMPD-disease genomic embedding evaluation
- metric
- accuracy
- metric direction
- higher
- dataset
- HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3
- protocol
- Frozen model last-hidden-state embeddings, mean pooled. Logistic regression for eight classification tasks and mini-batch k-means for eight clustering tasks. Source paper Section 5.3. Current official gene-mteb implementation corroborates task identities but its commit is not proven identical to the paper evaluator. Exact dataset release, split hash, scored counts and evaluator commit are unreported in the paper. Do not substitute current mutable HF main for the original split.
- source locator
- Table 3 (S5.T3), row HMPD-disease, column DNABERT-2; Section 5.3 paragraphs S5.SS3.p2.1 and S5.SS3.p3.1
- comparison panels
- id: metagene-gene-mteb-panel-hmpd-disease; title: Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation; protocol id: metagene-gene-mteb-task-hmpd-disease; dataset id: metagene-gene-mteb-dataset-hmpd-disease-gene-mteb-data-used-in-metagene-1-table-3; metric: accuracy; unit: fraction; direction: higher; result ids: metagene-gene-mteb-result-dnabert-2-hmpd-disease-accuracy; metagene-gene-mteb-result-dnabert-s-hmpd-disease-accuracy; metagene-gene-mteb-result-nt-2-5b-multi-hmpd-disease-accuracy; metagene-gene-mteb-result-nt-2-5b-1000g-hmpd-disease-accuracy; metagene-gene-mteb-result-metagene-1-hmpd-disease-accuracy; source ids: coverage-source-metagene-paper-v1; source locator: Table 3 (S5.T3), row HMPD-disease, column DNABERT-2; Section 5.3 paragraphs S5.SS3.p2.1 and S5.SS3.p3.1; context: Every method Gene-MTEB genomic embedding benchmark reports on HMPD-disease genomic embedding evaluation, scored with accuracy on HMPD-disease Gene-MTEB data used in METAGENE-1 Table 3.; caveats: All 16 component tasks and five methods are included. Twenty-five printed aggregate cells are retained in a companion receipt, excluded from task-level result counts to avoid counting derived averages as extra experiments.; Classification accuracy and clustering V-measure must not be combined into a universal performance metric.; Paper source does not pin exact evaluator/data revisions or per-task denominators. Current code metadata uses mutable dataset revision main; its development metadata is not asserted to be the evaluated paper version.; Paper calls embeddings zero-shot; this does not mean classification is label-free: logistic-regression probes use training labels.; No uncertainty intervals or repeats are printed.; review: method: automated_source_review; date: 2026-09-23
- entity level
- protocol
Related records
- part of: Gene-MTEB
- subject: Gene-MTEB genomic embedding benchmark HMPD-disease: part of discovery-benchmark-gene-mteb
- benchmark: DNABERT-2 on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- benchmark: DNABERT-S on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- benchmark: METAGENE-1 on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- benchmark: NT-2.5b-1000g on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation
- benchmark: NT-2.5b-Multi on Gene-MTEB genomic embedding benchmark HMPD-disease: HMPD-disease genomic embedding evaluation