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Protocol

GEARS Norman2019 CPA-control comparison

Source-specific reported comparison. Protocol details, fitted configurations and limitations are retained separately from other evaluations.

4 evaluations · 8 metric rows

Overview

Source-specific reported comparison. Protocol details, fitted configurations and limitations are retained separately from other evaluations.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Results

Each comparison retains its reviewed evaluation scope, dataset and metric. Results are shown without a pooled ranking.

GEARS Norman2019 CPA-control comparison MSE: Norman2019 perturbation-response MSE

mse (squared_expression_units_unreported) · Lower values are better.

Every method GEARS Norman2019 CPA-control comparison reports on Norman2019 perturbation-response MSE, scored with Mean squared error on Norman et al.2019 perturbation data used in GEARS Supplementary Table6.

GEARS Norman2019 CPA-control comparison MSE: Norman2019 perturbation-response MSE · Norman et al.2019 perturbation data used in GEARS Supplementary Table6 (GEARS Norman2019 CPA-control comparison split)

Evidence origin: Author-reported evaluation. Numerical source review does not establish independent reproduction.

GEARS primary supplement, Table6 · Supplementary Table6, printed p34 / PDF p35; metric definitions Table1; Supplementary Note5.

Complete four-method table; author-reported results, not reproduced.

All comparison limitations (5)
  • Complete four-method table; author-reported results, not reproduced.
  • The table prints ± spreads without defining SD, SE or CI in its caption. Preserve the printed values and mark spread type unreported.
  • The table labels MSE without explicitly restating the scored gene subset. Top20 is usual in this paper, but is not silently inferred for this table.
  • Exact split manifests, assay counts scored, checkpoint revision and evaluator commit are unextracted.
  • No Perturb also occurs in Table5 and may be reused evidence; no independent replicate is claimed.

Automated source review: 2026-09-23.

No unavailable values; missing scores remain labelled and are never plotted as zero.

Showing 4 of 4 matching rows.

Tested configuration
0.1960.290.3840.4770.571
Reported score
  1. No Perturb0.551 ± 0.029
  2. CPA0.354 ± 0.049
  3. CPA + KG0.333 ± 0.046
  4. GEARS0.216 ± 0.053

Dots show point estimates. Whiskers show only explicitly defined uncertainty (standard deviation, standard error or a labelled interval); their definitions remain in Table. Unresolved uncertainty is not plotted. Differences do not establish statistical significance.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

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Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

No reviewed evaluations with results linked in this release.

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Select a task-valid null control after reviewing inputs and metric

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Select an upstream conventional reference after reviewing the full protocol

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums

Coverage is derived from release 2026-09-23-2b89723c6dd9. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

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Run this benchmark

The supplementary table reports this evaluation. Rewire has not run it and has no maintained reproduction recipe. Exact evaluator and split revisions remain unextracted.

A maintained rewire runner has not been verified for this benchmark. Check data access, weights, licences, dependencies and hardware in the linked official documentation; requirements have not been fully extracted.

GEARS primary supplement, Table6 · Supplementary Table6, printed p34 / PDF p35; metric definitions Table1; Supplementary Note5.
Strengths, limitations and unresolved questions

Evidence

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Evidence table

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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-23-2b89723c6dd9
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Sources and history

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Release 2026-09-23-2b89723c6dd9 · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: model-coverage-gears-norman-cpa-controls

areas
cells-spatial-multiomics
run documentation
record id: model-coverage-gears-norman-cpa-controls; status: source_reviewed_not_executed; source ids: coverage-source-gears-supp; source locator: Supplementary Table6, printed p34 / PDF p35; metric definitions Table1; Supplementary Note5.; summary: The supplementary table reports this evaluation. Rewire has not run it and has no maintained reproduction recipe. Exact evaluator and split revisions remain unextracted.
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