Result

0.723 auc

ESM-1v (ensemble) · ProteinGym ZS-SUB-AUC · AUC

Tested configuration: ESM-1v (ensemble)
Task: ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
Dataset subset: ProteinGym substitution DMS assays (ProteinGym split)
Procedure: Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.
Evaluation: ESM-1v (ensemble) on ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
Evidence: Author-reported evaluation · source checkedProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 2, row(ESM-1v (ensemble)), column(Zero-shot substitutions, AUC)

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Methods and reproduction

ProteinGym evaluation of ESM-1v (ensemble) on Zero-shot substitutions, AUC, scored with AUC.

task: ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
configuration: ESM-1v (ensemble)
dataset subset: ProteinGym substitution DMS assays (ProteinGym split)
Split: Not reported
Adaptation: Not reported
Scoring implementation: AUC

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Access requirements and official instructions: ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evaluation results

Release 2026-09-17-134cd1815de8 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard. Where several source tables report the same metric, the published comparisons above offer a pooled view that names what it does not hold constant.

Evaluation setupMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
ESM-1v (ensemble) on ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC Configuration: ESM-1v (ensemble)Task: ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUCDataset subset: ProteinGym substitution DMS assays (ProteinGym split) Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes. Author-reported evaluation · Evaluation metadata: source checked
0.723 auc Unit: fraction · Direction: higher	Uncertainty: Not reported Scored: Not reported · Eligible: Not reported	source checkedProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 2, row(ESM-1v (ensemble)), column(Zero-shot substitutions, AUC) Source checking is not independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-134cd1815de8
Property and statement	Original source and location	Review and provenance
Reported result 0.723 Individual claims	ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design Original source ↗ Table 2, row(ESM-1v (ensemble)), column(Zero-shot substitutions, AUC) Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256 Retrieved: 2026-09-17T08:06:28.522924+00:00	source checked Deterministic parse of the pinned PDF text layer, reading each table from its heading row down to its own caption · 2026-09-18 author reported Audit details Source checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied. Field: `attributes.printed_value` Source artifact SHA-256: `a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104` Hash scope: Exact retrieved primary paper artifact bytes. Inspected artifact Extraction artifact SHA-256: `a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104` Extraction artifact

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Sources and history

Release 2026-09-17-134cd1815de8 · Record review: source checked

1 source records and release history

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256

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Technical metadata and extraction receipts

Stable ID: proteingym-result-esm-1v-ensemble-zs-sub-auc-auc

areas: proteins-complexes
tasks: Zero-shot substitutions, AUC
metric: auc
metric direction: higher
unit: fraction
printed value: 0.723
numeric value: 0.723
uncertainty: Not reported
source locator: Table 2, row(ESM-1v (ensemble)), column(Zero-shot substitutions, AUC)
missing metadata: denominator: unextracted; seeds: unreported
review: method: Deterministic parse of the pinned PDF text layer, reading each table from its heading row down to its own caption; reviewer: Codex research agent; no human review claimed; date: 2026-09-18; artifact sha256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104; retrieval url: https://papers.nips.cc/paper/2023/file/cac723e5ff29f65e3fcbb0739ae91bee-Paper-Datasets_and_Benchmarks.pdf; notes: Source checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied.

Related records

evaluation: ESM-1v (ensemble) on ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC

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