0.720 auc
ESM-2 (15B) · ProteinGym ZS-SUB-AUC · AUC
- Tested configuration
- ESM-2 (15B)
- Task
- ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
- Dataset subset
- ProteinGym substitution DMS assays (ProteinGym split)
- Procedure
- Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes.
- Evaluation
- ESM-2 (15B) on ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
- Evidence
- Author-reported evaluation · source checkedProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 2, row(ESM-2 (15B)), column(Zero-shot substitutions, AUC)
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Methods and reproduction
ProteinGym evaluation of ESM-2 (15B) on Zero-shot substitutions, AUC, scored with AUC.
- task
- ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC
- configuration
- ESM-2 (15B)
- dataset subset
- ProteinGym substitution DMS assays (ProteinGym split)
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- AUC
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evaluation results
Release 2026-09-17-134cd1815de8 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard. Where several source tables report the same metric, the published comparisons above offer a pooled view that names what it does not hold constant.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESM-2 (15B) on ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUC Configuration: ESM-2 (15B)Task: ProteinGym ZS-SUB-AUC: Zero-shot substitutions, AUCDataset subset: ProteinGym substitution DMS assays (ProteinGym split) Zero-shot scoring of substitution assays, averaged over assays with the correction the paper describes. Author-reported evaluation · Evaluation metadata: source checked | ||
| 0.720 auc Unit: fraction · Direction: higher | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Table 2, row(ESM-2 (15B)), column(Zero-shot substitutions, AUC) Source checking is not independent reproduction. |
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 0.720 Individual claims | ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design Table 2, row(ESM-2 (15B)), column(Zero-shot substitutions, AUC) Version: Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256 | source checked Deterministic parse of the pinned PDF text layer, reading each table from its heading row down to its own caption · 2026-09-18 author reported Audit detailsSource checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied. Field: Source artifact SHA-256: Hash scope: Exact retrieved primary paper artifact bytes. Extraction artifact SHA-256: |
Sources and history
Release 2026-09-17-134cd1815de8 · Record review: source checked
1 source records and release history
- ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Technical metadata and extraction receipts
Stable ID: proteingym-result-esm-2-15b-zs-sub-auc-auc
- areas
- proteins-complexes
- tasks
- Zero-shot substitutions, AUC
- metric
- auc
- metric direction
- higher
- unit
- fraction
- printed value
- 0.720
- numeric value
- 0.720
- uncertainty
- Not reported
- source locator
- Table 2, row(ESM-2 (15B)), column(Zero-shot substitutions, AUC)
- missing metadata
- denominator: unextracted; seeds: unreported
- review
- method: Deterministic parse of the pinned PDF text layer, reading each table from its heading row down to its own caption; reviewer: Codex research agent; no human review claimed; date: 2026-09-18; artifact sha256: a3b08cc4a6befd64620cf0f287d78d55a36dc2639955f52c5655f83833c50104; retrieval url: https://papers.nips.cc/paper/2023/file/cac723e5ff29f65e3fcbb0739ae91bee-Paper-Datasets_and_Benchmarks.pdf; notes: Source checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied.