rewire.it
Task

RNA tertiary structure

RNA tertiary-structure evaluation compares predicted three-dimensional RNA geometry with reference structures.

Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

0 evaluations · 0 metric rows

At a glance

Inputs, training, access and other details

Explanatory profile: source reviewed · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
Entity typeTask guide; concrete protocol identities remain separate.
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
DatasetsNo single dataset is fixed by this guide. Select a linked protocol and its versioned data release. · Not applicable
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
OrganismsNo shared organism population is defined at this guide level. Record it for each selected dataset. · Not applicable
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
AssaysNo single measurement assay is fixed by this guide; the endpoint and assay belong to the selected protocol. · Not applicable
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
SplitsNo executable split is attached to this task identity. Use the selected protocol’s split manifest. · Not applicable
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
Allowed inputsRNA sequence and permitted auxiliary information, plus a reference structure for geometric evaluation.
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
AdaptationNo common fitting regime is imposed here. Keep pretrained, frozen, probed, fine-tuned and conventional methods distinct where applicable. · Not applicable
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
MetricsProtocol-defined structural accuracy. Atom selection, reference states and treatment of missing residues must accompany a number.
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
BaselinesUse complete RNA-structure predictors and their stated input information; a language-model family name alone does not identify a structural pipeline.
Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

How it works

How it worksConceptual evaluation workflow
Conceptual evaluation workflow1. Select targets and reference states. Then: 2. Declare inputs and full prediction pipeline. Then: 3. Predict RNA coordinates. Then: 4. Align and score the specified atomsConceptual evaluation workflow1. Select targets and reference states. Then: 2. Declare inputs and full prediction pipeline. Then: 3. Predict RNA coordinates. Then: 4. Align and score the specified atomsConceptual evaluation workflow1. Select targets and reference states. Then: 2. Declare inputs and full prediction pipeline. Then: 3. Predict RNA coordinates. Then: 4. Align and score the specified atoms

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
Choosing an evaluation

Declare the target molecules and available inputs, including whether an alignment is allowed. Compare coordinates against the relevant reference state using an explicit alignment and atom-selection rule. The AlphaFold 3 paper describes a CASP15 RNA comparison; the RNA-FM project documents RhoFold as a separate complete predictor. A base RNA embedding model is not itself that evaluated pipeline.

Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
Task scope

This is a task guide, not a single versioned benchmark protocol. The connected resources provide examples or concrete procedures. A candidate method or proposed control is not evidence that an evaluation has been completed.

Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Tested entities and results

Release 2026-09-17-d277315f7d76 · 0 evaluations · 0 metric rows. Different protocols are not a single leaderboard.

No evaluations linked in this release.

Papers and result coverage

Last literature check: 2026-09-17. Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.

Paper or primary resourceVersionReference
Accurate structure prediction of biomolecular interactions with AlphaFold 3Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256Read source

What is still missing

  • complete comparable numeric result batch: Specific candidate tables and protocol boundaries are documented; no graph values or incomplete winner-only selection are converted into publishable rows.
Search and extraction details

primary protocol reviewed

Searches

  • RNAfold RNA secondary structure benchmark BPfold RhoFold RNA-FM paper

Evidence locations

  • AF3 Fig. 1; Extended Data Fig. 3; Supplementary Methods referenced by primary paper

Strengths and limitations

Strengths supported by sources

  • Coordinate-level scoring tests a structural endpoint beyond nucleotide pairing or embedding quality.
    Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Limitations and conditions

  • Alternative conformations and incomplete experimental structures complicate reference comparison. Predictions are not a calibrated dynamic ensemble.
    Sources (2)ml4bio/RNA-FM official source; AlphaFold 3 paper · RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets
Profile review details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Stable record: catalog-task-rna-tertiary-structure

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

34 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Individual claims
AlphaFold 3 paper

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 2024; DOI 10.1038/s41586-024-07487-w; XML retrieved 2026-09-16
Retrieved: 2026-09-16T19:56:24.856478+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: e627083f74d990b275e96a7503eee3e3eae9e3035b8efb28321277fcac6f1d6e

Hash scope: primary_artifact_review

Inspected artifact

Diagram caption

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Individual claims
ml4bio/RNA-FM official source

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Diagram steps

["Select targets and reference states","Declare inputs and full prediction pipeline","Predict RNA coordinates","Align and score the specified atoms"]

Individual claims
AlphaFold 3 paper

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 2024; DOI 10.1038/s41586-024-07487-w; XML retrieved 2026-09-16
Retrieved: 2026-09-16T19:56:24.856478+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: e627083f74d990b275e96a7503eee3e3eae9e3035b8efb28321277fcac6f1d6e

Hash scope: primary_artifact_review

Inspected artifact

Diagram steps

["Select targets and reference states","Declare inputs and full prediction pipeline","Predict RNA coordinates","Align and score the specified atoms"]

Individual claims
ml4bio/RNA-FM official source

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Diagram title

Conceptual evaluation workflow

Individual claims
AlphaFold 3 paper

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 2024; DOI 10.1038/s41586-024-07487-w; XML retrieved 2026-09-16
Retrieved: 2026-09-16T19:56:24.856478+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.title

Source artifact SHA-256: e627083f74d990b275e96a7503eee3e3eae9e3035b8efb28321277fcac6f1d6e

Hash scope: primary_artifact_review

Inspected artifact

Diagram title

Conceptual evaluation workflow

Individual claims
ml4bio/RNA-FM official source

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.title

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Entity type

Task guide; concrete protocol identities remain separate.

Individual claims
AlphaFold 3 paper

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 2024; DOI 10.1038/s41586-024-07487-w; XML retrieved 2026-09-16
Retrieved: 2026-09-16T19:56:24.856478+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: e627083f74d990b275e96a7503eee3e3eae9e3035b8efb28321277fcac6f1d6e

Hash scope: primary_artifact_review

Inspected artifact

Entity type

Task guide; concrete protocol identities remain separate.

Individual claims
ml4bio/RNA-FM official source

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Datasets

No single dataset is fixed by this guide. Select a linked protocol and its versioned data release.

Individual claims
AlphaFold 3 paper

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature 2024; DOI 10.1038/s41586-024-07487-w; XML retrieved 2026-09-16
Retrieved: 2026-09-16T19:56:24.856478+00:00

inapplicable

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: e627083f74d990b275e96a7503eee3e3eae9e3035b8efb28321277fcac6f1d6e

Hash scope: primary_artifact_review

Inspected artifact

Datasets

No single dataset is fixed by this guide. Select a linked protocol and its versioned data release.

Individual claims
ml4bio/RNA-FM official source

Original source ↗

RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

inapplicable

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: discovered

5 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: catalog-task-rna-tertiary-structure

areas
rna-transcriptomes
entity level
task
version
Not reported
task
RNA tertiary structure
scope note
Compare predicted 3D folds against independently held-out structures.
benchmark research
review date: 2026-09-17; status: primary_protocol_reviewed; primary sources: evidence-expansion-alphafold3-e627083f; inspected locators: AF3 Fig. 1; Extended Data Fig. 3; Supplementary Methods referenced by primary paper; searched queries: RNAfold RNA secondary structure benchmark BPfold RhoFold RNA-FM paper; gaps: complete comparable numeric result batch: Specific candidate tables and protocol boundaries are documented; no graph values or incomplete winner-only selection are converted into publishable rows.; claim scope: Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.
historical missing metadata
protocol version: not_yet_extracted
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This record identifies the biological prediction question or a suite-specific task, rather than a uniquely fixed evaluated procedure. Preserve its task identity and leave split, model adaptation and scoring details on linked protocols/evaluations.; source ids: src-discovery-ml4bio-rna-fm; evidence-alphafold-paper; source locator: RNA-FM README: RhoFold; AlphaFold 3 Methods: Nucleic acid prediction baseline and CASP15 RNA targets; ambiguities: None recorded
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