rewire.it
Task

microbiome disease-state classification

Microbiome disease-state classification evaluates independent disease/control cohorts through leave-one-out prediction.

SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

1 evaluation · 1 metric row

At a glance

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
DatasetsFour gut-microbiome datasets with IBD, type-2 diabetes, liver-cirrhosis or colorectal-cancer labels and controls.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
SplitsLeave-one-out cross-validation excludes the held-out sample from both embedding training and final classifier training.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
MetricsAccuracy, precision and recall.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
BaselinesRandom forest, XGBoost, principal-component regression, lasso and SVM.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
Leakage controlsThe source explicitly removes the held-out sample from both learning stages.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
UncertaintyThe cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim. · Not reported in inspected sources
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
Entity typePaper-specific computational evaluation protocol.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
OrganismsHuman gut microbial communities.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
AssaysMicrobiome profiles with disease/control labels.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
Allowed inputsMicrobiome composition/features.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
AdaptationEmbedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.
SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

How it works

How it worksComputational evaluation flow
Computational evaluation flow1. Input: Microbiome composition/features.. Then: 2. Evaluation: Embedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.. Then: 3. Readout: Accuracy, precision and recall.Computational evaluation flow1. Input: Microbiome composition/features.. Then: 2. Evaluation: Embedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.. Then: 3. Readout: Accuracy, precision and recall.Computational evaluation flow1. Input: Microbiome composition/features.. Then: 2. Evaluation: Embedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.. Then: 3. Readout: Accuracy, precision and recall.

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30
Evaluation methodology

Four gut-microbiome datasets with IBD, type-2 diabetes, liver-cirrhosis or colorectal-cancer labels and controls. Leave-one-out cross-validation excludes the held-out sample from both embedding training and final classifier training. Accuracy, precision and recall. Random forest, XGBoost, principal-component regression, lasso and SVM. The source explicitly removes the held-out sample from both learning stages. The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.

SourcesMultimodal deep learning applied to classify healthy and disease states of human microbiome · Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Tested entities and results

Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
MDL4Microbiome: microbiome disease-state classification

Multimodal deep learning model on colorectal-cancer versus healthy microbiome samples

Author-reported evaluation · Evaluation metadata: needs review

0.97 accuracy

Unit: fraction · Direction: unknown

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedMultimodal deep learning applied to classify healthy and disease states of human microbiome · Table 3, CRC row, MDL4Microbiome column

Source checking is not independent reproduction.

Papers and result coverage

Last literature check: 2026-09-17. Primary-paper discovery and source inspection. Source-checked results are not independently reproduced experiments.

Paper or primary resourceVersionReference
Multimodal deep learning applied to classify healthy and disease states of human microbiomePMC archival version PMC8763943.1Read source
DOI: 10.1038/s41598-022-04773-3

What is still missing

  • Disease datasets and cohort prevalences differ; do not pool accuracy.
  • No uncertainty in Table 3. Visualization using a 7:3 split is not the evaluation split.
Search and extraction details

primary comparison table screened

Searches

  • "PMC8763943"

Evidence locations

  • Table 3
  • Methods: Performance evaluation

Strengths and limitations

Profile review details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Stable record: reported-task-e2009c35eabd69

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["Input: Microbiome composition/features.","Evaluation: Embedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.","Readout: Accuracy, precision and recall."]

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Computational evaluation flow

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Datasets

Four gut-microbiome datasets with IBD, type-2 diabetes, liver-cirrhosis or colorectal-cancer labels and controls.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Splits

Leave-one-out cross-validation excludes the held-out sample from both embedding training and final classifier training.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Adaptation

Embedding and classifier training are repeated inside leave-one-out folds, excluding the held-out subject sample.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Metrics

Accuracy, precision and recall.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Baselines

Random forest, XGBoost, principal-component regression, lasso and SVM.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Leakage controls

The source explicitly removes the held-out sample from both learning stages.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

source checked

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Uncertainty

The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.

Individual claims
Multimodal deep learning applied to classify healthy and disease states of human microbiome

Original source ↗

Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30

Version: PMC archival version PMC8763943.1
Retrieved: 2026-09-16T10:33:58.492Z

unreported

automated source review · 2026-09-16

Audit details

Task-specific computational methodology and field context checked in the cited primary-source artifact. Source-backed fields, inapplicable evaluator dimensions and unresolved details are distinguished. Numerical results were not reproduced.

Field: attributes.profile.facts.5.value

Source artifact SHA-256: 72330eda245ac97c5de5d47a491bb86d9b8f527a03ae25fa41cae5bfb637143b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-task-e2009c35eabd69

areas
microbes-communities
tasks
microbiome disease-state classification
entity level
task
version
Not reported
task
microbiome disease-state classification
scope note
Paper-specific evaluation task; protocol completeness requires further extraction.
benchmark research
review date: 2026-09-17; status: primary_comparison_table_screened; primary sources: expansion-p3-mdl4microbiome-2022; inspected locators: Table 3; Methods: Performance evaluation; searched queries: "PMC8763943"; gaps: Disease datasets and cohort prevalences differ; do not pool accuracy.; No uncertainty in Table 3. Visualization using a 7:3 split is not the evaluation split.; claim scope: Primary-paper discovery and source inspection. Source-checked results are not independently reproduced experiments.
historical missing metadata
protocol version: not_reported_in_legacy_extract; split: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This source-scoped record identifies the biological prediction task and holds its paper context. Preserve the existing task identity; exact split, model adaptation and scoring remain in linked evaluations or separate protocol records.; source ids: mdl4microbiome-2022; source locator: Methods: Data preparation and preprocessing; Performance evaluation; cached text lines 10–12, 28–30; ambiguities: A paper- or suite-specific task may constrain some inputs or metrics; that alone does not make it interchangeable with a complete versioned protocol. No protocol equivalence is inferred.; Some legacy profile Entity type facts use the generic phrase computational evaluation protocol. That boilerplate is not sufficient to establish a single fixed protocol identity or to merge this task with another protocol record.
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