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Configuration

UFold

UFold is a learned RNA-secondary-structure comparator in the TU-Fold study.

SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods/Training method (paragraph 3); Results/TU-fold outperforms existing methods without using post-processing steps (paragraph 2)

1 evaluation · 1 metric row

How it worksEvaluated procedure (conceptual)
Evaluated procedure (conceptual)1. RNA nucleotide sequences. Then: 2. UFold. Then: 3. RNA secondary-structure base pairsEvaluated procedure (conceptual)1. RNA nucleotide sequences. Then: 2. UFold. Then: 3. RNA secondary-structure base pairsEvaluated procedure (conceptual)1. RNA nucleotide sequences. Then: 2. UFold. Then: 3. RNA secondary-structure base pairs

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)

At a glance

Model type

Convolutional RNA folding model; this record is the paper-specific evaluated configuration.

Sourcesuci-cbcl/UFold README.md · README.md model description

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
UFold: RNA secondary structure

Three-fold training and evaluation; source reports mean and standard deviation.

Independent external evaluation · Evaluation metadata: needs review

0.938 F1

Unit: unitless · Direction: unknown

Uncertainty: ± 0.004 standard deviation

Scored: Not reported · Eligible: Not reported

source checkedRNA secondary structure prediction by conducting multi-class classifications · Table 2, UFold row, Overall F1 column

Source checking is not independent reproduction.

How it works

How the evaluated method works

RNA sequences become an image-like pairwise representation processed by a fully convolutional network, with base-pairing rules supporting structure prediction.

SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)
Underlying method and version boundaries

UFold converts RNA sequences into an image-like representation and uses a fully convolutional network, trained on annotated structures and pairing rules, to predict secondary structure.

Sourcesuci-cbcl/UFold README.md · README.md; introduction, model description, pretrained-model and usage sections at pinned revision
What was evaluated

The linked evaluation record identifies UFold: RNA secondary structure. Its dataset, split, adaptation and evidence origin remain attached to the reported results.

SourcesRNA secondary structure prediction by conducting multi-class classifications · The named evaluation’s methods and comparison table; exact preserved evaluation IDs: evaluation-lit-014

Strengths and limitations

Strengths and considerations

Profile review details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Stable record: reported-model-e3abb0b9a2ec79

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
PropertyDescription and evidence
Model typeConvolutional RNA folding model; this record is the paper-specific evaluated configuration.
Sourcesuci-cbcl/UFold README.md · README.md model description
Architecture / procedureRNA sequences become an image-like pairwise representation processed by a fully convolutional network, with base-pairing rules supporting structure prediction.
SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)
Biological inputsRNA nucleotide sequences
SourcesRNA secondary structure prediction by conducting multi-class classifications · CRediT authorship contribution statement (paragraph 1); Discussion (paragraph 3)
OutputsRNA secondary-structure base pairs
SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods/Training method (paragraph 3); Materials and methods/Data augmentation (paragraph 2)
ParametersAn aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. · Not reported in inspected sources
Sources (2)RNA secondary structure prediction by conducting multi-class classifications; uci-cbcl/UFold README.md · Materials and methods/Training method; Materials and methods/Evaluation method; Materials and methods/Data augmentation; Materials and methods/Knowledge merge; Materials and methods/Experimental settings; Results/TU-fold outperforms existing methods without using post-processing steps; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision
Known versions / configurationUFold is the comparison-table label; that label does not specify an immutable weight revision. · Not reported in inspected sources
SourcesRNA secondary structure prediction by conducting multi-class classifications · Model identification in the comparison table and corresponding Methods; immutable checkpoint revision is not supplied by the table label.
Training data / fittingThe comparison evaluates UFold on the RNA8F collection under three random train/validation/test partitions. RNA8F combines RNAStrAlign, ArchiveII, bpRNA and CRW2, with CD-HIT filtering at 0.9. Exact UFold optimiser/checkpoint details are not stated in the comparison passage.
SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods / Experimental settings; Table 2
Context limitsThe evaluated RNA8F collection contains sequences of at most 500 nucleotides. This is a dataset restriction, not a universal UFold inference limit.
SourcesRNA secondary structure prediction by conducting multi-class classifications · Materials and methods / Experimental settings
AccessOfficial upstream implementation and usage documentation: https://github.com/uci-cbcl/UFold/blob/75bd9acc83826059682dfca9d3659df66b132cd1/README.md. This pinned documentation revision is not automatically the evaluated weight revision.
Sourcesuci-cbcl/UFold README.md · README.md; installation, model download and usage instructions
Code licenceMIT (upstream repository code at the cited revision; this does not establish every dependency or historical checkpoint licence).
Sourcesuci-cbcl/UFold LICENSE · LICENSE; complete licence text
Weights licenceThe inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately. · Not reported in inspected sources
Sourcesuci-cbcl/UFold README.md · README.md; checkpoint/access documentation and licence scope

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

21 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["RNA nucleotide sequences","UFold","RNA secondary-structure base pairs"]

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Evaluated procedure (conceptual)

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Model type

Convolutional RNA folding model; this record is the paper-specific evaluated configuration.

Individual claims
uci-cbcl/UFold README.md

Original source ↗

README.md model description

Version: 75bd9acc83826059682dfca9d3659df66b132cd1
Retrieved: 2026-09-16T20:00:03.913031+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 9ef66e737e1047f7028f8f636516f5d0144f9395fe5aceb1a387d1ba457c81f2

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Architecture / procedure

RNA sequences become an image-like pairwise representation processed by a fully convolutional network, with base-pairing rules supporting structure prediction.

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Weights licence

The inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately.

Individual claims
uci-cbcl/UFold README.md

Original source ↗

README.md; checkpoint/access documentation and licence scope

Version: 75bd9acc83826059682dfca9d3659df66b132cd1
Retrieved: 2026-09-16T20:00:03.913031+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 9ef66e737e1047f7028f8f636516f5d0144f9395fe5aceb1a387d1ba457c81f2

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Biological inputs

RNA nucleotide sequences

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

CRediT authorship contribution statement (paragraph 1); Discussion (paragraph 3)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Outputs

RNA secondary-structure base pairs

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method (paragraph 3); Materials and methods/Data augmentation (paragraph 2)

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
uci-cbcl/UFold README.md

Original source ↗

Materials and methods/Training method; Materials and methods/Evaluation method; Materials and methods/Data augmentation; Materials and methods/Knowledge merge; Materials and methods/Experimental settings; Results/TU-fold outperforms existing methods without using post-processing steps; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 75bd9acc83826059682dfca9d3659df66b132cd1
Retrieved: 2026-09-16T20:00:03.913031+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 9ef66e737e1047f7028f8f636516f5d0144f9395fe5aceb1a387d1ba457c81f2

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
RNA secondary structure prediction by conducting multi-class classifications

Original source ↗

Materials and methods/Training method; Materials and methods/Evaluation method; Materials and methods/Data augmentation; Materials and methods/Knowledge merge; Materials and methods/Experimental settings; Results/TU-fold outperforms existing methods without using post-processing steps; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: version of record
Retrieved: 2026-09-16T10:41:16.505799+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 5aa376d6466daee83fc307baa39fd48da0f185ff30a178624025032d4cbe597d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

3 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-model-e3abb0b9a2ec79

areas
rna-transcriptomes
entity level
method
version
Not reported
reported name
UFold
historical missing metadata
version: not_reported_in_legacy_extract; checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
model
entity classification
review date: 2026-09-17; rationale: This source-scoped entry preserves the method/configuration actually named in an evaluation. It is neither a global family identity nor proof of an immutable checkpoint; the linked evaluation retains adaptation, fitting and scoring details.; source ids: tu-fold-2025; evidence-reported-base-ufold-readme-md; source locator: Materials and methods/Training method (paragraph 1); Materials and methods/Training method (paragraph 3) | README.md model description | Materials and methods/Training method (paragraph 3); Results/TU-fold outperforms existing methods without using post-processing steps (paragraph 2); ambiguities: Configuration means the source-labelled evaluated identity. It does not establish missing checkpoint hashes, default settings or equivalence to same-named records in other papers.
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