Configuration

Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)

One seed-0 random ranking on all 2,972 AMFR variants. This is one complete assay, not the full ProteinGym track or an estimate of a chance-performance interval.

1 evaluation · 5 metric rows

Overview

One seed-0 random ranking on all 2,972 AMFR variants. This is one complete assay, not the full ProteinGym track or an estimate of a chance-performance interval.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 5 metric rows. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR seeded-random control Dataset subset: ProteinGym v1.3 AMFR stability assay, 2,972 variants	0.514 AUC dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported Seeded random ranking control: report; Seeded random ranking control: audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.AUC
Configuration: Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR seeded-random control Dataset subset: ProteinGym v1.3 AMFR stability assay, 2,972 variants	0.019 MCC dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported Seeded random ranking control: report; Seeded random ranking control: audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC
Configuration: Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR seeded-random control Dataset subset: ProteinGym v1.3 AMFR stability assay, 2,972 variants	0.526 NDCG dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported Seeded random ranking control: report; Seeded random ranking control: audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.NDCG
Configuration: Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR seeded-random control Dataset subset: ProteinGym v1.3 AMFR stability assay, 2,972 variants	0.008 Spearman dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported Seeded random ranking control: report; Seeded random ranking control: audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.Spearman
Configuration: Seeded random ranking control (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR seeded-random control Dataset subset: ProteinGym v1.3 AMFR stability assay, 2,972 variants	0.087 Top_recall dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported Seeded random ranking control: report; Seeded random ranking control: audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.Top_recall

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Release 2026-09-22-f58a0f1d267f · Record review: source checked

2 source records and release history

Seeded random ranking control: report · Original source · 1663d1f04b2bbd6dfcff77fea78129d30b0de191
Seeded random ranking control: audit · Original source · 1663d1f04b2bbd6dfcff77fea78129d30b0de191

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Technical metadata and extraction receipts

Stable ID: rewire-local-20260921-configuration-proteingym-random

areas: proteins-complexes
source locator: model; model_configuration; protocol_configuration.embedding_probe; execution
configuration: baseline id: seeded-random-v1; baseline version: 1; limitation: One seeded control is not an uncertainty estimate; IDs bind the run; method: SHA256(seed:prepared_id), first 64 bits / 2**64; seed: 0
execution: adapter: SeededRandomScore; batch size: 32; fitting: none; inference and fit seconds: 0.005387083001551218; mode: local_adapter; prediction type: scalar
model: name: Seeded random ranking control; training overlap: no labelled fitting
environment: architecture: arm64; container digest: unreported; container runtime: unreported; platform: macOS-26.6.2-arm64-arm-64bit; python: 3.11.13; rewirebench: 0.4.0; sdk code sha256: 08cbbaac2aa8f60af5c43af7a83410e9690b44c5e4d162fbe1e5766885952fce; sif sha256: unreported
training overlap: no labelled fitting
method role: null control

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configuration: Seeded random ranking control on ProteinGym v1.3 AMFR substitution assay

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