evaluation · needs review

ESM2 OFS pseudo-perplexity: protein variant fitness prediction

Evaluation procedure

authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Release 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
ESM2 OFS pseudo-perplexity: protein variant fitness prediction Model: ESM2 OFS pseudo-perplexity · Benchmark: protein variant fitness prediction · Dataset: ProteinGym substitutions authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays Author-reported evaluation · Evaluation metadata: needs review
0.403 Spearman rho Unit: unitless · Direction: unknown	Uncertainty: not reported in legacy extract Scored: Not reported · Eligible: Not reported	source checkedPseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column Source checking is not independent reproduction.

Release 2026-09-16-d74d282221a9 · Record review: needs review

Technical metadata and extraction receipts

Stable ID: evaluation-b2-esm2-ofs-fitness-2025

areas: proteins-complexes
tasks: protein variant fitness prediction
origin: author_reported
protocol: authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays
version: not stated in table
comparison: protocol id: Not reported; dataset version: Not reported; split: aggregate across assays; population: Not reported; inputs: Not reported; adaptation: Not reported; metric implementation: Not reported; aggregation: Not reported; budget: Not reported
missing metadata: dataset version: not_reported_in_legacy_extract

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