Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
model · method
ESM2 OFS pseudo-perplexity
ESM2 OFS pseudo-perplexity is the method recorded for protein variant fitness prediction. This page preserves the configuration reported by Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation.
At a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.
| Property | Description and evidence |
|---|---|
| Recorded dataset | ProteinGym substitutionsPseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column |
| Recorded split | aggregate across assaysPseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column |
| Recorded configuration | not stated in tablePseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column |
| Model type | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
How it works
Recorded evaluation
The imported evaluation describes this procedure: authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean columnBenchmarks and results
Release 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESM2 OFS pseudo-perplexity: protein variant fitness prediction Model: ESM2 OFS pseudo-perplexity · Benchmark: protein variant fitness prediction · Dataset: ProteinGym substitutions authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.403 Spearman rho Unit: unitless · Direction: unknown | Uncertainty: not reported in legacy extract Scored: Not reported · Eligible: Not reported | source checkedPseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column Source checking is not independent reproduction. |
Strengths and limitations
Limitations and conditions
- This is an evidence-limited profile. The recorded evaluation context does not establish performance on other datasets or configurations.Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column
Profile review details
Reviewed the existing release record, its source pointer and linked evaluation context. This is not a fresh full-text architecture review or independent reproduction; numerical review status is unchanged.
Stable record: reported-model-40ce004270dee4Sources and history
Release 2026-09-16-d74d282221a9 · Record review: needs review
- Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Original source · PRX Life 2025 journal article
Technical metadata and extraction receipts
Stable ID: reported-model-40ce004270dee4
- areas
- proteins-complexes
- entity level
- method
- version
- not stated in table
- reported name
- ESM2 OFS pseudo-perplexity
- missing metadata
- checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract