Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
model · method
AbSplice: retrained AbSplice (paper Table 4)
AbSplice: retrained AbSplice (paper Table 4). A comparator reported by the AlphaGenome authors; protocol pages specify the dataset and adaptation.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTExAt a glance
Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Reported method | AbSpliceAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx |
| Exact checkpoint | Not established by the summary table; inspect the protocol and original implementation. · Needs further source reviewAlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx |
| Model type | Not extracted or verified for this record. |
| Inputs | Not extracted or verified for this record. |
| Outputs | Not extracted or verified for this record. |
| Parameters | Not extracted or verified for this record. |
| Training data | Not extracted or verified for this record. |
| Context limits | Not extracted or verified for this record. |
| Access | Not extracted or verified for this record. |
| Code licence | Not extracted or verified for this record. |
| Weights licence | Not extracted or verified for this record. |
How it works
How this comparator was evaluated
The source table identifies AbSplice. Fit an Explainable Boosting Classifier on the training/validation data and evaluate the held-out variants.
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTExBenchmarks and results
Release 2026-09-17-a757f4af4277 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| AbSplice: retrained AbSplice (paper Table 4): Supervised GTEx splicing-outlier prediction Model: AbSplice: retrained AbSplice (paper Table 4) · Benchmark: Supervised GTEx splicing-outlier prediction (AlphaGenome paper) · Dataset: Supervised GTEx splicing-outlier prediction: evaluated data subset Fit an Explainable Boosting Classifier on the training/validation data and evaluate the held-out variants. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.251 auprc Unit: dimensionless · Direction: higher Aggregation: Pooled auPRC across GTEx tissues after assigning positive variants their observed tissues and negatives tissues sampled to match the positive tissue distribution. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L7 Source checking is not independent reproduction. |
Strengths and limitations
Limitations and conditions
- A table label does not establish identity with any other catalogue configuration bearing the same name.AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx
Profile review details
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-comparator-e2cd76fdc569f86eEvidence table
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
15 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported method AbSplice Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Reported method AbSplice Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Reported method AbSplice Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Exact checkpoint Not established by the summary table; inspect the protocol and original implementation. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | unextracted automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Limitation A table label does not establish identity with any other catalogue configuration bearing the same name. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| How this comparator was evaluated The source table identifies AbSplice. Fit an Explainable Boosting Classifier on the training/validation data and evaluate the held-out variants. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 4 Variant performan'!A7:P7; Supplementary Methods p.30, Chromosome Splits for Variant Benchmarks; Supplementary Methods p.31, Splicing Outliers from GTEx Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-a757f4af4277 · Record review: needs review
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-comparator-e2cd76fdc569f86e
- areas
- dna-genomes
- entity level
- method
- configuration type
- pipeline
- version
- AbSplice: retrained AbSplice (paper Table 4)