Strengths and considerations
No source-reviewed explanatory claims are recorded here yet.
Protocol
Human splice-site classification: RNA-derived (AlphaGenome paper)
Can the model identify donor and acceptor splice sites on each DNA strand?
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3At a glance
Inputs, training, access and other details
Explanatory profile: limited source coverage · Automated source review, 2026-09-17. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.
| Property | Description and evidence |
|---|---|
| Dataset and biological context | RNA-seq-observed splice sites from filtered STAR junctions; the two label sources are separate evaluations.Sources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Split | Fold-1 ensemble evaluated on held-out intervals from chromosomes 1,3,5,7,9 to overlap the peer models’ test data.Sources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Allowed inputs and adaptation | Reference DNA sequence and predicted donor+/acceptor+/donor−/acceptor− probabilities; SpliceAI and DeltaSplice are comparison models.Sources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Metrics as reported | auPRCSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Aggregation | Compute auPRC separately for four strand/site classes and average the four values.Sources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Uncertainty | Not reported for these summary-table scores. · Not reported in inspected sourcesSources (3)AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 |
| Organisms | Not extracted or verified for this record. |
| Assays | Not extracted or verified for this record. |
| Baselines | Not extracted or verified for this record. |
How it works
How it worksHuman splice-site classification: RNA-derived: evaluation procedure
Conceptual summary of the cited procedure; model-specific conditions are given below.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3What is tested
Can the model identify donor and acceptor splice sites on each DNA strand?
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3Procedure
Compare probabilities with the selected binary splice-site labels at genomic positions.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3Recorded evaluations
Each evaluation records what was tested and under which conditions.
Published comparisons
Explore the results reported under one evaluation protocol. Each figure keeps its source, dataset and metric together; it is not a ranking across studies.
Human splice-site classification: RNA-derived (AlphaGenome paper)
auPRC (dimensionless) · Higher values are better for this metric.
Can the model identify donor and acceptor splice sites on each DNA strand?
Evaluation protocol · Human splice-site classification: RNA-derived: evaluated data subset
- SpliceAI (paper Table 3) · Configuration · Author-reported evaluation0.755
- DeltaSplice (paper Table 3) · Configuration · Author-reported evaluation0.783
- AlphaGenome ensemble of four fold-1 models · Configuration · Author-reported evaluation0.79
Source order is preserved. Plotted marks show point estimates; uncertainty, where reported, is retained in the printed values and table. Differences do not establish statistical significance.
AlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J2; 'Suppl Table 3 Track performance'!J3; 'Suppl Table 3 Track performance'!K2; 'Suppl Table 3 Track performance'!K3Values, uncertainty and evidence
| Tested entity | Printed value | Uncertainty | Evidence |
|---|---|---|---|
| SpliceAI (paper Table 3) · Configuration | 0.755 dimensionless | Not reported | Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J2 |
| DeltaSplice (paper Table 3) · Configuration | 0.783 dimensionless | Not reported | Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J3 |
| AlphaGenome ensemble of four fold-1 models · Configuration | 0.79 dimensionless | Not reported | Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K2; 'Suppl Table 3 Track performance'!K3 |
Scope and limitations
- This is the AlphaGenome paper’s comparison. Source-checked scores are not independent reproductions.
- Model inputs, training and inference budgets differ or remain partly unextracted. This figure does not establish a controlled architectural advantage.
- Superseded and quarantined score conflicts are excluded; comparator-specific subsets remain separate.
Source transcription and grouping reviewed by automated source review on 2026-09-17. These experiments were not independently reproduced by rewire.
Tested entities and results
Release 2026-09-17-d277315f7d76 · 3 evaluations · 3 metric rows. Different protocols are not a single leaderboard.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| SpliceAI (paper Table 3): Human splice-site classification: RNA-derived Configuration: SpliceAI (paper Table 3)Protocol: Human splice-site classification: RNA-derived (AlphaGenome paper)Dataset subset: Human splice-site classification: RNA-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.755 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J2 Source checking is not independent reproduction. |
| DeltaSplice (paper Table 3): Human splice-site classification: RNA-derived Configuration: DeltaSplice (paper Table 3)Protocol: Human splice-site classification: RNA-derived (AlphaGenome paper)Dataset subset: Human splice-site classification: RNA-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.783 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!J3 Source checking is not independent reproduction. |
| AlphaGenome ensemble of four fold-1 models: Human splice-site classification: RNA-derived Configuration: AlphaGenome ensemble of four fold-1 modelsProtocol: Human splice-site classification: RNA-derived (AlphaGenome paper)Dataset subset: Human splice-site classification: RNA-derived: evaluated data subset Compare probabilities with the selected binary splice-site labels at genomic positions. Author-reported evaluation · Evaluation metadata: needs review | ||
| 0.79 auPRC Unit: dimensionless · Direction: higher Aggregation: Compute auPRC separately for four strand/site classes and average the four values. | Uncertainty: unreported Scored: Not reported · Eligible: Not reported | source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 3 Track performance'!K2; 'Suppl Table 3 Track performance'!K3 Source checking is not independent reproduction. |
Papers and result coverage
Last literature check: 2026-09-17. Original Nature paper comparison; numerical source transcription was separately reviewed. No independent model execution.
| Paper or primary resource | Version | Reference |
|---|---|---|
| alphagenome: Journal full-text XML | Retrieved page snapshot; no immutable publisher revision supplied | Read source |
| AlphaGenome Nature 2026 supplementary comparison tables | Nature version of record, 28 January 2026 | Read source DOI: 10.1038/s41586-025-10014-0 |
| AlphaGenome Nature 2026 supplementary methods | Supplement to Nature version of record, 28 January 2026; content hash pinned | Read source |
What is still missing
- Individual protocol input manifests, scoring counts and uncertainty remain unextracted where explicitly marked.
- Subsequent studies use different datasets and are not pooled with this paper.
Search and extraction details
complete comparison extracted
Searches
- AlphaGenome benchmark evaluation Nature 2026 supplementary Tables 3 4 regulatory variant prediction
- AlphaGenome independent evaluation benchmark 2026 variant effects
Evidence locations
- 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3
Strengths and limitations
Limitations and conditions
- RNA-derived labels represent observed sites; GTF labels represent annotation. These are not interchangeable populations. Pangolin is excluded because its outputs do not separate donors from acceptors.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 - This is an author-reported protocol, not a rewire rerun. Different datasets, processing and adaptations cannot support an unrestricted leaderboard.
Sources (3)
AlphaGenome Nature 2026 supplementary comparison tables; AlphaGenome Nature 2026 supplementary methods; alphagenome: Journal full-text XML · 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3
Profile review details
Primary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction.
Stable record: alphagenome-2026-t3-protocol-1Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
42 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram caption Conceptual summary of the cited procedure; model-specific conditions are given below. Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Diagram steps ["Held-out sequence","Predict four splice-site classes","Match RNA-derived or GTF labels","Average class-specific auPRC"] Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram steps ["Held-out sequence","Predict four splice-site classes","Match RNA-derived or GTF labels","Average class-specific auPRC"] Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram steps ["Held-out sequence","Predict four splice-site classes","Match RNA-derived or GTF labels","Average class-specific auPRC"] Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Diagram title Human splice-site classification: RNA-derived: evaluation procedure Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
| Diagram title Human splice-site classification: RNA-derived: evaluation procedure Individual claims | AlphaGenome Nature 2026 supplementary methods 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplement to Nature version of record, 28 January 2026; content hash pinned | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact publisher PDF bytes Format: original_pdf |
| Diagram title Human splice-site classification: RNA-derived: evaluation procedure Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature version of record, 28 January 2026 | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx |
| Dataset and biological context RNA-seq-observed splice sites from filtered STAR junctions; the two label sources are separate evaluations. Individual claims | alphagenome: Journal full-text XML 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Retrieved page snapshot; no immutable publisher revision supplied | source checked automated source review · 2026-09-17 Audit detailsPrimary-source transcription and separate automated source review. No human sign-off or independent experimental reproduction. Field: Source artifact SHA-256: Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact |
Sources and history
Release 2026-09-17-d277315f7d76 · Record review: needs review
3 source records and release history
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-t3-protocol-1
- areas
- dna-genomes
- entity level
- protocol
- version
- Nature version of record, 28 January 2026
- source evaluation index
- 1
- source table
- 3
- reference levels
- metric: auPRC; printed value: 0; numeric value: 0; source locator: Suppl Table 3 Track performance!H2; note: Source reference quantity for relative-performance calculation, not a measured baseline run.; metric: auPRC; printed value: 0; numeric value: 0; source locator: Suppl Table 3 Track performance!H3; note: Source reference quantity for relative-performance calculation, not a measured baseline run.
- comparison panels
- id: paper-figure-1d70978cedd96be9d2; title: Human splice-site classification: RNA-derived (AlphaGenome paper); protocol id: alphagenome-2026-t3-protocol-1; dataset id: alphagenome-2026-t3-dataset-1; metric: auPRC; unit: dimensionless; direction: higher; result ids: alphagenome-2026-result-50a549ab1abc3c1d; alphagenome-2026-result-66c6bb32dc329b7f; alphagenome-2026-result-8b641d8fe5b30f89; source ids: source-alphagenome-nature2026-tables; source locator: 'Suppl Table 3 Track performance'!J2; 'Suppl Table 3 Track performance'!J3; 'Suppl Table 3 Track performance'!K2; 'Suppl Table 3 Track performance'!K3; context: Can the model identify donor and acceptor splice sites on each DNA strand?; caveats: This is the AlphaGenome paper’s comparison. Source-checked scores are not independent reproductions.; Model inputs, training and inference budgets differ or remain partly unextracted. This figure does not establish a controlled architectural advantage.; Superseded and quarantined score conflicts are excluded; comparator-specific subsets remain separate.; review: method: automated_source_review; date: 2026-09-17
- benchmark research
- review date: 2026-09-17; status: complete_comparison_extracted; primary sources: evidence-official-56e5abfb5f12f1cd3b20; source-alphagenome-nature2026-tables; source-alphagenome-nature2026-supplementary-methods; inspected locators: 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3; searched queries: AlphaGenome benchmark evaluation Nature 2026 supplementary Tables 3 4 regulatory variant prediction; AlphaGenome independent evaluation benchmark 2026 variant effects; gaps: Individual protocol input manifests, scoring counts and uncertainty remain unextracted where explicitly marked.; Subsequent studies use different datasets and are not pooled with this paper.; claim scope: Original Nature paper comparison; numerical source transcription was separately reviewed. No independent model execution.
- legacy kinds
- benchmark
- entity classification
- review date: 2026-09-17; rationale: The source-backed record identifies a specified evaluated procedure and its dataset/split/scoring context. Classify it as a protocol while preserving version and comparison restrictions.; source ids: source-alphagenome-nature2026-tables; source-alphagenome-nature2026-supplementary-methods; evidence-official-56e5abfb5f12f1cd3b20; source locator: 'Suppl Table 3 Track performance'!A2:N2; 'Suppl Table 3 Track performance'!A3:N3; Supplementary Methods p.22, Splice Site Classification; methods: p.22, Splice Site Classification; paper: Extended Data Fig.2b; tables: Suppl Table 3 Track performance; evaluation index 1; sheet rows 2, 3; ambiguities: None recorded
Related records
- benchmark: SpliceAI (paper Table 3): Human splice-site classification: RNA-derived
- benchmark: DeltaSplice (paper Table 3): Human splice-site classification: RNA-derived
- benchmark: AlphaGenome ensemble of four fold-1 models: Human splice-site classification: RNA-derived
- benchmark: Human splice-site classification: RNA-derived: evaluated data subset