benchmark · task

Mutated RBD binding prediction

This paper-specific evaluation tests Mutated RBD binding prediction using PRIME mutated RBD.

At a glance

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. This does not change the review status of its results.

Data, procedure and scoring
Property	Description and evidence
Record type	Paper-specific task; protocol incompletely extractedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
Inputs	PRIME mutated RBDPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
Assessment	R²PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
Recorded split or evaluation setting	position-stratifiedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
Datasets	Not extracted or verified for this record.
Organisms	Not extracted or verified for this record.
Assays	Not extracted or verified for this record.
Adaptation	Not extracted or verified for this record.
Baselines	Not extracted or verified for this record.

How it works

Reported evaluation outline

Outline of the existing paper extraction. Split membership, fitting details and scorer implementation remain incompletely reviewed.

Read the diagram as text

PRIME mutated RBD
Recorded fitting or scoring procedure
Assess R²

PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

Evaluation context

The existing paper extraction describes: Frozen mean-pooled representation with downstream regression; position-stratified split. This description is retained with the exact evaluation records; it is not a new protocol reconstruction.

Tested models and results

Release 2026-09-16-d74d282221a9 · 2 evaluations · 2 metric rows. Different protocols are not a single leaderboard.

Evaluated configurationMetricEvidence origin

Results grouped by the exact reported evaluation
Metric and finding	Coverage and uncertainty	Evidence
ESM-2: Mutated RBD binding prediction Model: ESM-2 · Benchmark: Mutated RBD binding prediction · Dataset: PRIME mutated RBD Frozen mean-pooled representation with downstream regression; position-stratified split. Independent external evaluation · Evaluation metadata: needs review
0.0248 R² Unit: unitless · Direction: unknown	Uncertainty: ± 0.01 Scored: Not reported · Eligible: Not reported	source checkedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column Source checking is not independent reproduction.
ESM-C: Mutated RBD binding prediction Model: ESM-C · Benchmark: Mutated RBD binding prediction · Dataset: PRIME mutated RBD Frozen mean-pooled representation with downstream regression; position-stratified split. Independent external evaluation · Evaluation metadata: needs review
-0.0162 R² Unit: unitless · Direction: unknown	Uncertainty: ± 0.01 Scored: Not reported · Eligible: Not reported	source checkedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column Source checking is not independent reproduction.

Strengths and limitations

Strengths and considerations

The linked evaluation identifies the paper-specific dataset and assessment rather than treating the task name as a universal benchmark.PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

Limitations and conditions

The numerical table check does not establish the full data-processing, fitting or leakage-control protocol.PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; Table 1, ESM-C 300M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

Profile review details

Catalogue extraction inspected; protocol claims remain limited to the cited evidence. Missing details are not presumed absent from the original paper.

Stable record: reported-task-00e594df6a182d

Sources and history

Release 2026-09-16-d74d282221a9 · Record review: needs review

PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Original source · version of record

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Technical metadata and extraction receipts

Stable ID: reported-task-00e594df6a182d

areas: proteins-complexes
tasks: Mutated RBD binding prediction
entity level: task
version: Not reported
task: Mutated RBD binding prediction
scope note: Paper-specific evaluation task; protocol completeness requires further extraction.
missing metadata: protocol version: not_reported_in_legacy_extract

Related records

dataset: PRIME mutated RBD
benchmark: ESM-2: Mutated RBD binding prediction
benchmark: ESM-C: Mutated RBD binding prediction

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