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result · source checked

0.0248 R²

ESM-2 · R² · PRIME mutated RBD

Tested model
ESM-2
Task or benchmark
Mutated RBD binding prediction
Dataset
PRIME mutated RBD
Procedure
Frozen mean-pooled representation with downstream regression; position-stratified split.
Evaluation
ESM-2: Mutated RBD binding prediction
Evidence
Independent external evaluation · source checkedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Evaluation results

Release 2026-09-16-d74d282221a9 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
ESM-2: Mutated RBD binding prediction
Model: ESM-2 · Benchmark: Mutated RBD binding prediction · Dataset: PRIME mutated RBD

Frozen mean-pooled representation with downstream regression; position-stratified split.

Independent external evaluation · Evaluation metadata: needs review

0.0248 R²

Unit: unitless · Direction: unknown

Uncertainty: ± 0.01

Scored: Not reported · Eligible: Not reported

source checkedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

Source checking is not independent reproduction.

Sources and history

Release 2026-09-16-d74d282221a9 · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: lit-021

areas
proteins-complexes
tasks
Mutated RBD binding prediction
printed value
0.0248
numeric value
0.0248
metric
R²
metric direction
unknown
unit
unitless
uncertainty
± 0.01
source locator
Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
review
method: independent_ai_table_review; reviewer: Codex omics research agent; independent source-table review, not human review; reviewed at: 2026-09-16T10:41:16.525183+00:00; notes: Resolved model row spans and Mean/CLS subrows in JATS: selected Mean, not fine-tuned (cross), Position-Stratified Split > Binding > R-squared. Central value agrees; uncertainty is retained in evidence. This verifies the central score at its source location, not every metadata field or an experimental reproduction.; evidence: {"table_xml_id": "Tab1", "row_cells": ["Mean", "×", "0.6794 ± 0.02", "1.0777 ± 0.04", "0.6576 ± 0.04", "0.5807 ± 0.03", "0.0248 ± 0.01", "1.7519 ± 0.01", "0.0967 ± 0.02", "1.0221 ± 0.01"], "selected_cell_zero_based": 6, "selected_cell_xml": "<td align=\"left\" colspan=\"1\" rowspan=\"1\">0.0248 ± 0.01</td>", "caption": "Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression"}; artifact sha256: f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13425921/fullTextXML
legacy id
lit-021
legacy row
id: lit-021; paper id: prime-2026; domain id: proteins-complexes; task: Mutated RBD binding prediction; model: ESM-2; model version: 8M; dataset: PRIME mutated RBD; dataset version: Not reported; split: position-stratified; metric: R²; value: 0.0248; unit: unitless; uncertainty: ± 0.01; protocol: Frozen mean-pooled representation with downstream regression; position-stratified split.; source locator: Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; source url: https://pmc.ncbi.nlm.nih.gov/articles/PMC13425921/; evaluation origin: independent_paper; reviewed utc: 2026-09-15T23:25:00Z
missing metadata
dataset version: not_reported_in_legacy_extract
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