ESMC-300M supervised
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Overview
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
Release 2026-09-19-eb6149e5d766 · 16 evaluations · 32 metric rows. Different protocols are not a single leaderboard. Charts retain each source table’s protocol and dataset.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESMC-300M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro Configuration: ESMC-300M supervisedProtocol: FLIP2 hydro to-P0A9X9; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P0A9X9; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.078 ± 0.133 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.133; type: unreported; value: 0.133 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.970 ± 0.001 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 TrpB by-position; held-out test set · TrpB Configuration: ESMC-300M supervisedProtocol: FLIP2 TrpB by-position; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB by-position; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.980 ± 0.007 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 Configuration: ESMC-300M supervisedProtocol: FLIP2 PDZ3 single-to-double; held-out test set · PDZ3Dataset subset: PDZ3 FLIP2 PDZ3 single-to-double; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.499 ± 0.018 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.018; type: unreported; value: 0.018 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.889 ± 0.011 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.011; type: unreported; value: 0.011 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase Configuration: ESMC-300M supervisedProtocol: FLIP2 Amylase by-mutation; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase by-mutation; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.061 ± 0.130 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.130; type: unreported; value: 0.13 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.793 ± 0.030 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.030; type: unreported; value: 0.03 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 hydro to-P01053; held-out test set · hydro Configuration: ESMC-300M supervisedProtocol: FLIP2 hydro to-P01053; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P01053; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.949 ± 0.024 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.024; type: unreported; value: 0.024 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| 0.329 ± 0.190 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.190; type: unreported; value: 0.19 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase Configuration: ESMC-300M supervisedProtocol: FLIP2 Amylase one-to-many; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.869 ± 0.028 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.028; type: unreported; value: 0.028 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| 0.148 ± 0.181 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.181; type: unreported; value: 0.181 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 hydro to-P06241; held-out test set · hydro Configuration: ESMC-300M supervisedProtocol: FLIP2 hydro to-P06241; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P06241; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.934 ± 0.011 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.011; type: unreported; value: 0.011 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| 0.161 ± 0.184 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.184; type: unreported; value: 0.184 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 hydro three-to-many; held-out test set · hydro Configuration: ESMC-300M supervisedProtocol: FLIP2 hydro three-to-many; held-out test set · hydroDataset subset: hydro FLIP2 hydro three-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.977 ± 0.007 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| 0.399 ± 0.174 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.174; type: unreported; value: 0.174 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB Configuration: ESMC-300M supervisedProtocol: FLIP2 TrpB two-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.991 ± 0.003 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB Configuration: ESMC-300M supervisedProtocol: FLIP2 TrpB one-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.306 ± 0.063 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.063; type: unreported; value: 0.063 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.992 ± 0.001 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase Configuration: ESMC-300M supervisedProtocol: FLIP2 Amylase far-to-close; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase far-to-close; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.011 ± 0.066 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.066; type: unreported; value: 0.066 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.819 ± 0.011 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.011; type: unreported; value: 0.011 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 hydro low-to-high; held-out test set · hydro Configuration: ESMC-300M supervisedProtocol: FLIP2 hydro low-to-high; held-out test set · hydroDataset subset: hydro FLIP2 hydro low-to-high; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.099 ± 0.194 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.194; type: unreported; value: 0.194 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.870 ± 0.030 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.030; type: unreported; value: 0.03 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 IRED two-to-many; held-out test set · IRED Configuration: ESMC-300M supervisedProtocol: FLIP2 IRED two-to-many; held-out test set · IREDDataset subset: IRED FLIP2 IRED two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.954 ± 0.002 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M supervised · FLIP2 NucB two-to-many; held-out test set · NucB Configuration: ESMC-300M supervisedProtocol: FLIP2 NucB two-to-many; held-out test set · NucBDataset subset: NucB FLIP2 NucB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.723 ± 0.002 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M supervised; column spearman Source checking is not independent reproduction. |
| 0.966 ± 0.000 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.000; type: unreported; value: 0 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M supervised; column ndcg Source checking is not independent reproduction. |
Evidence table
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Sources and history
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Release 2026-09-19-eb6149e5d766 · Record review: discovered
1 source records and release history
- FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Technical metadata and extraction receipts
Stable ID: acquired-configuration-51e435f059eca0154ccf
- source locator
- Table A1; row ESMC-300M supervised; column spearman
- reported configuration
- ESMC-300M supervised
- reference kind
- not_a_reference
- missing metadata
- checkpoint revision: unreported; model family: unextracted
Related records
- model: ESMC-300M supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro
- model: ESMC-300M supervised · FLIP2 IRED two-to-many; held-out test set · IRED
- model: ESMC-300M supervised · FLIP2 rhomax by-wild-type; held-out test set · rhomax
- model: ESMC-300M supervised · FLIP2 hydro to-P06241; held-out test set · hydro
- model: ESMC-300M supervised · FLIP2 TrpB by-position; held-out test set · TrpB
- model: ESMC-300M supervised · FLIP2 NucB two-to-many; held-out test set · NucB
- model: ESMC-300M supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB
- model: ESMC-300M supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB
- model: ESMC-300M supervised · FLIP2 hydro three-to-many; held-out test set · hydro
- model: ESMC-300M supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3
- model: ESMC-300M supervised · FLIP2 hydro to-P01053; held-out test set · hydro
- model: ESMC-300M supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase
- model: ESMC-300M supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase
- model: ESMC-300M supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase
- model: ESMC-300M supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase
- model: ESMC-300M supervised · FLIP2 hydro low-to-high; held-out test set · hydro