ESMC-300M naive supervised
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Overview
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
Release 2026-09-19-eb6149e5d766 · 16 evaluations · 31 metric rows. Different protocols are not a single leaderboard. Charts retain each source table’s protocol and dataset.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESMC-300M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase far-to-close; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase far-to-close; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.818 ± 0.002 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro Configuration: ESMC-300M naive supervisedProtocol: FLIP2 hydro to-P06241; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P06241; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.098 ± 0.024 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.024; type: unreported; value: 0.024 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.927 ± 0.001 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED Configuration: ESMC-300M naive supervisedProtocol: FLIP2 IRED two-to-many; held-out test set · IREDDataset subset: IRED FLIP2 IRED two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.106 ± 0.005 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.005; type: unreported; value: 0.005 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.949 ± 0.001 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3 Configuration: ESMC-300M naive supervisedProtocol: FLIP2 PDZ3 single-to-double; held-out test set · PDZ3Dataset subset: PDZ3 FLIP2 PDZ3 single-to-double; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.880 ± 0.006 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.006; type: unreported; value: 0.006 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A16; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase one-to-many; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.850 ± 0.007 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.007; type: unreported; value: 0.007 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase close-to-far; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase close-to-far; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.864 ± 0.012 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.012; type: unreported; value: 0.012 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| 0.007 ± 0.032 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.032; type: unreported; value: 0.032 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 rhomax by-wild-type; held-out test set · rhomax Configuration: ESMC-300M naive supervisedProtocol: FLIP2 rhomax by-wild-type; held-out test set · rhomaxDataset subset: rhomax FLIP2 rhomax by-wild-type; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.936 ± 0.022 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.022; type: unreported; value: 0.022 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| 0.036 ± 0.218 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.218; type: unreported; value: 0.218 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB Configuration: ESMC-300M naive supervisedProtocol: FLIP2 TrpB one-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.986 ± 0.002 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB Configuration: ESMC-300M naive supervisedProtocol: FLIP2 TrpB by-position; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB by-position; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.154 ± 0.059 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.059; type: unreported; value: 0.059 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.978 ± 0.004 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.004; type: unreported; value: 0.004 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 hydro three-to-many; held-out test set · hydro Configuration: ESMC-300M naive supervisedProtocol: FLIP2 hydro three-to-many; held-out test set · hydroDataset subset: hydro FLIP2 hydro three-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.367 ± 0.042 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.042; type: unreported; value: 0.042 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.973 ± 0.002 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.002; type: unreported; value: 0.002 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB Configuration: ESMC-300M naive supervisedProtocol: FLIP2 NucB two-to-many; held-out test set · NucBDataset subset: NucB FLIP2 NucB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.956 ± 0.003 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.003; type: unreported; value: 0.003 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB Configuration: ESMC-300M naive supervisedProtocol: FLIP2 TrpB two-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.398 ± 0.020 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.020; type: unreported; value: 0.02 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.986 ± 0.001 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.001; type: unreported; value: 0.001 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 hydro to-P01053; held-out test set · hydro Configuration: ESMC-300M naive supervisedProtocol: FLIP2 hydro to-P01053; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P01053; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| −0.086 ± 0.135 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.135; type: unreported; value: 0.135 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| 0.895 ± 0.006 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.006; type: unreported; value: 0.006 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 hydro low-to-high; held-out test set · hydro Configuration: ESMC-300M naive supervisedProtocol: FLIP2 hydro low-to-high; held-out test set · hydroDataset subset: hydro FLIP2 hydro low-to-high; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.905 ± 0.008 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.008; type: unreported; value: 0.008 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
| 0.270 ± 0.048 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.048; type: unreported; value: 0.048 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro Configuration: ESMC-300M naive supervisedProtocol: FLIP2 hydro to-P0A9X9; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P0A9X9; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| −0.050 ± 0.193 spearman Unit: correlation · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.193; type: unreported; value: 0.193 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESMC-300M naive supervised; column spearman Source checking is not independent reproduction. |
| ESMC-300M naive supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase Configuration: ESMC-300M naive supervisedProtocol: FLIP2 Amylase by-mutation; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase by-mutation; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.819 ± 0.048 ndcg Unit: unitless · Direction: higher Aggregation: mean of five random-seed fits (Section 4.3) | Uncertainty: printed spread: 0.048; type: unreported; value: 0.048 Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESMC-300M naive supervised; column ndcg Source checking is not independent reproduction. |
Evidence table
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Sources and history
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Release 2026-09-19-eb6149e5d766 · Record review: discovered
1 source records and release history
- FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Technical metadata and extraction receipts
Stable ID: acquired-configuration-d2ee43f90addd1db86fd
- source locator
- Table A1; row ESMC-300M naive supervised; column spearman
- reported configuration
- ESMC-300M naive supervised
- reference kind
- not_a_reference
- missing metadata
- checkpoint revision: unreported; model family: unextracted
Related records
- model: ESMC-300M naive supervised · FLIP2 hydro to-P06241; held-out test set · hydro
- model: ESMC-300M naive supervised · FLIP2 TrpB by-position; held-out test set · TrpB
- model: ESMC-300M naive supervised · FLIP2 TrpB two-to-many; held-out test set · TrpB
- model: ESMC-300M naive supervised · FLIP2 NucB two-to-many; held-out test set · NucB
- model: ESMC-300M naive supervised · FLIP2 hydro low-to-high; held-out test set · hydro
- model: ESMC-300M naive supervised · FLIP2 TrpB one-to-many; held-out test set · TrpB
- model: ESMC-300M naive supervised · FLIP2 IRED two-to-many; held-out test set · IRED
- model: ESMC-300M naive supervised · FLIP2 hydro to-P01053; held-out test set · hydro
- model: ESMC-300M naive supervised · FLIP2 Amylase one-to-many; held-out test set · Amylase
- model: ESMC-300M naive supervised · FLIP2 Amylase by-mutation; held-out test set · Amylase
- model: ESMC-300M naive supervised · FLIP2 hydro to-P0A9X9; held-out test set · hydro
- model: ESMC-300M naive supervised · FLIP2 rhomax by-wild-type; held-out test set · rhomax
- model: ESMC-300M naive supervised · FLIP2 Amylase close-to-far; held-out test set · Amylase
- model: ESMC-300M naive supervised · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3
- model: ESMC-300M naive supervised · FLIP2 hydro three-to-many; held-out test set · hydro
- model: ESMC-300M naive supervised · FLIP2 Amylase far-to-close; held-out test set · Amylase