ESM2-650M likelihood
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Overview
Exact source-reported configuration or submission label. Family membership, checkpoint identity and aliases have not been inferred.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
Release 2026-09-19-eb6149e5d766 · 16 evaluations · 32 metric rows. Different protocols are not a single leaderboard. Charts retain each source table’s protocol and dataset.
| Metric and finding | Coverage and uncertainty | Evidence |
|---|---|---|
| ESM2-650M likelihood · FLIP2 hydro low-to-high; held-out test set · hydro Configuration: ESM2-650M likelihoodProtocol: FLIP2 hydro low-to-high; held-out test set · hydroDataset subset: hydro FLIP2 hydro low-to-high; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.865 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| −0.038 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A11; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 hydro to-P0A9X9; held-out test set · hydro Configuration: ESM2-650M likelihoodProtocol: FLIP2 hydro to-P0A9X9; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P0A9X9; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.049 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.964 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A13; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 hydro three-to-many; held-out test set · hydro Configuration: ESM2-650M likelihoodProtocol: FLIP2 hydro three-to-many; held-out test set · hydroDataset subset: hydro FLIP2 hydro three-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| −0.036 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.967 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A10; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 Amylase close-to-far; held-out test set · Amylase Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase close-to-far; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase close-to-far; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.955 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A2; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase one-to-many; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.942 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| 0.560 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A1; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 hydro to-P01053; held-out test set · hydro Configuration: ESM2-650M likelihoodProtocol: FLIP2 hydro to-P01053; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P01053; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.053 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.911 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A14; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED Configuration: ESM2-650M likelihoodProtocol: FLIP2 IRED two-to-many; held-out test set · IREDDataset subset: IRED FLIP2 IRED two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.141 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.953 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A5; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB Configuration: ESM2-650M likelihoodProtocol: FLIP2 TrpB two-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.992 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| 0.427 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A8; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 hydro to-P06241; held-out test set · hydro Configuration: ESM2-650M likelihoodProtocol: FLIP2 hydro to-P06241; held-out test set · hydroDataset subset: hydro FLIP2 hydro to-P06241; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.928 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| 0.017 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A12; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 rhomax by-wild-type; held-out test set · rhomax Configuration: ESM2-650M likelihoodProtocol: FLIP2 rhomax by-wild-type; held-out test set · rhomaxDataset subset: rhomax FLIP2 rhomax by-wild-type; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| −0.177 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.904 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A15; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB Configuration: ESM2-650M likelihoodProtocol: FLIP2 NucB two-to-many; held-out test set · NucBDataset subset: NucB FLIP2 NucB two-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.906 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A6; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB Configuration: ESM2-650M likelihoodProtocol: FLIP2 TrpB one-to-many; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB one-to-many; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.430 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A7; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase by-mutation; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase by-mutation; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.540 spearman Unit: correlation · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESM2-650M likelihood; column spearman Source checking is not independent reproduction. |
| 0.909 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A4; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase Configuration: ESM2-650M likelihoodProtocol: FLIP2 Amylase far-to-close; held-out test set · AmylaseDataset subset: Amylase FLIP2 Amylase far-to-close; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.932 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A3; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
| ESM2-650M likelihood · FLIP2 TrpB by-position; held-out test set · TrpB Configuration: ESM2-650M likelihoodProtocol: FLIP2 TrpB by-position; held-out test set · TrpBDataset subset: TrpB FLIP2 TrpB by-position; held-out test set Author-reported evaluation · Evaluation metadata: discovered | ||
| 0.988 ndcg Unit: unitless · Direction: higher Aggregation: reported point estimate | Uncertainty: Not reported Scored: Not reported · Eligible: Not reported | source checkedFLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Table A9; row ESM2-650M likelihood; column ndcg Source checking is not independent reproduction. |
Evidence table
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Sources and history
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Release 2026-09-19-eb6149e5d766 · Record review: discovered
1 source records and release history
- FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications · Original source · Primary full-text snapshot retrieved 2026-09-17; exact bytes pinned by SHA-256
Technical metadata and extraction receipts
Stable ID: acquired-configuration-e2c25d673da23695973b
- source locator
- Table A1; row ESM2-650M likelihood; column spearman
- reported configuration
- ESM2-650M likelihood
- reference kind
- not_a_reference
- missing metadata
- checkpoint revision: unreported; model family: unextracted
Related records
- model: ESM2-650M likelihood · FLIP2 hydro to-P01053; held-out test set · hydro
- model: ESM2-650M likelihood · FLIP2 hydro to-P06241; held-out test set · hydro
- model: ESM2-650M likelihood · FLIP2 TrpB by-position; held-out test set · TrpB
- model: ESM2-650M likelihood · FLIP2 NucB two-to-many; held-out test set · NucB
- model: ESM2-650M likelihood · FLIP2 TrpB two-to-many; held-out test set · TrpB
- model: ESM2-650M likelihood · FLIP2 Amylase far-to-close; held-out test set · Amylase
- model: ESM2-650M likelihood · FLIP2 PDZ3 single-to-double; held-out test set · PDZ3
- model: ESM2-650M likelihood · FLIP2 hydro low-to-high; held-out test set · hydro
- model: ESM2-650M likelihood · FLIP2 IRED two-to-many; held-out test set · IRED
- model: ESM2-650M likelihood · FLIP2 hydro three-to-many; held-out test set · hydro
- model: ESM2-650M likelihood · FLIP2 Amylase one-to-many; held-out test set · Amylase
- model: ESM2-650M likelihood · FLIP2 Amylase by-mutation; held-out test set · Amylase
- model: ESM2-650M likelihood · FLIP2 TrpB one-to-many; held-out test set · TrpB
- model: ESM2-650M likelihood · FLIP2 hydro to-P0A9X9; held-out test set · hydro
- model: ESM2-650M likelihood · FLIP2 rhomax by-wild-type; held-out test set · rhomax
- model: ESM2-650M likelihood · FLIP2 Amylase close-to-far; held-out test set · Amylase