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PlantCAD2

PlantCAD2 is a plant-specific, single-nucleotide genomic language model.

SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Abstract (paragraph 1); Methods/Accessible chromatin region prediction (paragraph 3)

1 evaluation · 1 metric row

How it worksEvaluated procedure (conceptual)
Evaluated procedure (conceptual)1. Plant genomic DNA at single-nucleotide resolution. Then: 2. PlantCAD2. Then: 3. Sequence representations, zero-shot scores and adapted regulatory predictionsEvaluated procedure (conceptual)1. Plant genomic DNA at single-nucleotide resolution. Then: 2. PlantCAD2. Then: 3. Sequence representations, zero-shot scores and adapted regulatory predictionsEvaluated procedure (conceptual)1. Plant genomic DNA at single-nucleotide resolution. Then: 2. PlantCAD2. Then: 3. Sequence representations, zero-shot scores and adapted regulatory predictions

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

At a glance

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

Release 2026-09-17-d277315f7d76 · 1 evaluation · 1 metric row. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
PlantCAD2: cross-species conservation prediction

Zero-shot score for conserved versus non-conserved sites from alignments of 35 Andropogoneae genomes

Author-reported evaluation · Evaluation metadata: needs review

0.725 AUROC

Unit: fraction · Direction: unknown

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Table 1, Cross-species evolutionary conservation > Conservation within Andropogoneae (Genome-wide) row, PlantCAD2 AUROC entry

Source checking is not independent reproduction.

How it works

How the evaluated method works

A Caduceus-style bidirectional, reverse-complement-equivariant architecture uses Mamba2 blocks and masked-language pretraining.

SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)
What was evaluated

The linked evaluation record identifies PlantCAD2: cross-species conservation prediction. Its dataset, split, adaptation and evidence origin remain attached to the reported results.

SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · The named evaluation’s methods and comparison table; exact preserved evaluation IDs: evaluation-lit-b4-002

Strengths and limitations

Profile review details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Stable record: reported-model-65059c3a806306

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
PropertyDescription and evidence
Model typeStudy-specific predictive method; this record is the paper-specific evaluated configuration.
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)
Architecture / procedureA Caduceus-style bidirectional, reverse-complement-equivariant architecture uses Mamba2 blocks and masked-language pretraining.
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)
Biological inputsPlant genomic DNA at single-nucleotide resolution
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Repeat annotation and loss re-weighting (paragraph 2); Introduction (paragraph 4)
OutputsSequence representations, zero-shot scores and adapted regulatory predictions
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Results/Transcription factor binding sites revealed by high-confidence predictions of PlantCAD2 (paragraph 1); Methods/Evolutionary constraint prediction using the zero-shot strategy (paragraph 3)
ParametersAn aggregate parameter total for this exact evaluated configuration is not established by the inspected sources. · Not reported in inspected sources
Sources (2)PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms; plantcad/plantcad README.md · Methods/Preparing pre-training genomes; Methods/PlantCAD2 model architecture and pre-training; Methods/Repeat annotation and loss re-weighting; Methods/Evolutionary constraint prediction using the zero-shot strategy; Methods/Core and non-core gene classification using the zero-shot strategy; Methods/Accessible chromatin region prediction; Methods/Gene expression prediction in leaf; Methods/Leaf protein abundance prediction task; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision
Known versions / configurationPlantCAD2 is the comparison-table label; that label does not specify an immutable weight revision. · Not reported in inspected sources
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Model identification in the comparison table and corresponding Methods; immutable checkpoint revision is not supplied by the table label.
Training data / fitting65 angiosperm genomes
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/Preparing pre-training genomes (paragraph 1); Methods/PlantCAD2 model architecture and pre-training (paragraph 3)
Context limits8,192 base pairs
SourcesPlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms · Methods/PlantCAD2 model architecture and pre-training (paragraph 3); Introduction (paragraph 4)
AccessOfficial study implementation and usage documentation: https://github.com/plantcad/plantcad/blob/7240f0238f869b3ac25e4b5ad0996fad96ede9db/README.md. This pinned documentation revision is not automatically the evaluated weight revision.
Sourcesplantcad/plantcad README.md · README.md; installation, model download and usage instructions
Code licenceApache 2.0 (study repository code at the cited revision; this does not establish every dependency or historical checkpoint licence).
Sourcesplantcad/plantcad LICENSE · LICENSE; complete licence text
Weights licenceThe inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately. · Not reported in inspected sources
Sourcesplantcad/plantcad README.md · README.md; checkpoint/access documentation and licence scope

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

20 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual input–method–output guide. Check the procedure text and linked evaluation for fitted components, additional inputs and exact settings.

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["Plant genomic DNA at single-nucleotide resolution","PlantCAD2","Sequence representations, zero-shot scores and adapted regulatory predictions"]

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Evaluated procedure (conceptual)

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Model type

Study-specific predictive method; this record is the paper-specific evaluated configuration.

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Architecture / procedure

A Caduceus-style bidirectional, reverse-complement-equivariant architecture uses Mamba2 blocks and masked-language pretraining.

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Weights licence

The inspected model-access documentation does not explicitly identify terms for this exact evaluated checkpoint or fitted head; repository code terms are shown separately.

Individual claims
plantcad/plantcad README.md

Original source ↗

README.md; checkpoint/access documentation and licence scope

Version: 7240f0238f869b3ac25e4b5ad0996fad96ede9db
Retrieved: 2026-09-16T19:54:20.832487+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 74ef9550db6752e6d99441c48751919e172ce5e2ce83cf57deaa08f24df1df8e

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Biological inputs

Plant genomic DNA at single-nucleotide resolution

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Repeat annotation and loss re-weighting (paragraph 2); Introduction (paragraph 4)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Outputs

Sequence representations, zero-shot scores and adapted regulatory predictions

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Results/Transcription factor binding sites revealed by high-confidence predictions of PlantCAD2 (paragraph 1); Methods/Evolutionary constraint prediction using the zero-shot strategy (paragraph 3)

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

source checked

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
plantcad/plantcad README.md

Original source ↗

Methods/Preparing pre-training genomes; Methods/PlantCAD2 model architecture and pre-training; Methods/Repeat annotation and loss re-weighting; Methods/Evolutionary constraint prediction using the zero-shot strategy; Methods/Core and non-core gene classification using the zero-shot strategy; Methods/Accessible chromatin region prediction; Methods/Gene expression prediction in leaf; Methods/Leaf protein abundance prediction task; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 7240f0238f869b3ac25e4b5ad0996fad96ede9db
Retrieved: 2026-09-16T19:54:20.832487+00:00

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 74ef9550db6752e6d99441c48751919e172ce5e2ce83cf57deaa08f24df1df8e

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Parameters

An aggregate parameter total for this exact evaluated configuration is not established by the inspected sources.

Individual claims
PlantCAD2: A Long-Context DNA Language Model for Cross-Species Functional Annotation in Angiosperms

Original source ↗

Methods/Preparing pre-training genomes; Methods/PlantCAD2 model architecture and pre-training; Methods/Repeat annotation and loss re-weighting; Methods/Evolutionary constraint prediction using the zero-shot strategy; Methods/Core and non-core gene classification using the zero-shot strategy; Methods/Accessible chromatin region prediction; Methods/Gene expression prediction in leaf; Methods/Leaf protein abundance prediction task; inspected for aggregate parameter count (component sizes are not added without an exact configuration); README.md at pinned repository revision

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: preprint version in PMC
Retrieved: 2026-09-16T10:41:06Z

unreported

automated source review · 2026-09-16

Audit details

Primary full text and the available official implementation/model documentation were inspected. Explanatory claims are source-backed; unresolved exact-configuration metadata is labelled explicitly. This is automated review, not a human review or independent benchmark reproduction.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 4891955edb33af61e36dad51110574aa242e77c2df36429f100ff5a54bd8bd4b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

3 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-model-65059c3a806306

areas
dna-genomes
entity level
method
version
Not reported
reported name
PlantCAD2
historical missing metadata
version: not_reported_in_legacy_extract; checkpoint revision: not_reported_in_legacy_extract; training data: not_reported_in_legacy_extract; licence: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
model
entity classification
review date: 2026-09-17; rationale: This source-scoped entry preserves the method/configuration actually named in an evaluation. It is neither a global family identity nor proof of an immutable checkpoint; the linked evaluation retains adaptation, fitting and scoring details.; source ids: plantcad2-2025; source locator: Methods/Zero-shot evaluation of Evo2 model (paragraph 2); Results/PlantCAD2: a long-context DNA language model for angiosperms (paragraph 1) | Abstract (paragraph 1); Methods/Accessible chromatin region prediction (paragraph 3); ambiguities: Configuration means the source-labelled evaluated identity. It does not establish missing checkpoint hashes, default settings or equivalence to same-named records in other papers.
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